CNS/Neurology

This technology is a fully integrated holographic microscope system capable of simultaneous, high-resolution imaging and precise stimulation of 3D neuronal circuits using optogenetics.

This technology is a hybrid configuration of multi-coils and radiofrequency magnets that can improve clinical magnetic resonance imaging (MRI) quality.

This technology is a set of transgenic zebrafish lines expressing hallmark proteins of Alzheimer’s disease with similar pathology to human brains for use as a tool in early drug development.

This technology is an in vitro platform for assessing the role of epigenetic changes in neuropsychiatric diseases.

Quantitative measurement of eye and head movements for the diagnosis of traumatic brain injury and neurodegeneration.

This technology uses peptides secreted by engineered bacteria to reduce virulence of Fusobacterium nucleatum.

This technology is a comprehensive compound design and preclinical testing platform that can be used to develop multifunctional drugs for Alzheimer’s disease, and has already led to the development of several promising lead compounds.

This technology is an automated screening algorithm that analyzes patterns in verbal communication for early stage diagnosis of Alzheimer’s disease and related cognitive impairments.

This technology is a set of fiducial markers that attach to the surgical head holder during robotic neurosurgery to improve precision of volumetric computed tomography scans.

This technology describes an Amigo2-Cre BAC animal model for evaluation of the synaptic connections and role of the CA2 region in the hippocampus.

This technology is a tool to identify compounds that block the activity of TIA1, an RNA-binding protein that regulates stress granule formation and the generation of pathological forms of tau protein, and is implicated in a range of neurodegenerative diseases.

Unmet Need: Multi-functional amplifier for precise intracellular recordings.

This technology is a customizable platform for growing micro-organ cultures to study multimodal physiological responses and potentially facilitate more efficient, cost-effective drug development.

This technology describes the mechanism of action and use of compound FIN56, a specific inducer of ferroptosis.

This technology is NeuroScore AI, an automated AI program that can be used to calculate Alzheimer’s Disease risk score by transcribing audio files from standardized cognitive testing.