Cardio - Columbia Technology Ventures

Cardio

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Real-time guidance of RFA catheter contact orientation
This technology is a method and computer-accessible medium for determining catheter contact orientation with optical coherence tomography (OCT) for direct visualization of surfaces during radiofrequency ablation (RFA) therapy.
8
CatheterContact angleLesion
Christine P. HendonCindy YuRajinder Singh-Moon
Dovina Qu
Biomedical EngineeringElectrical Engineering
Fu Foundation School of Engineering and Applied Science (SEAS)
2020-12-02
Continuous, self-calibrating, cuffless, and non-invasive blood pressure monitor
This technology consists of a wearable wrist device that provides continuous blood pressure monitoring that is self-calibrating and utilizes a combination of positional sensors and machine-learning algorithms to adjust for changes in hydrostatic pressure due to arm movement.
8
Ambulatory careBiometricsBlood pressure
David ColburnSamuel Sia Ph.D.
Dovina Qu
Biomedical Engineering
Fu Foundation School of Engineering and Applied Science (SEAS)
2023-10-20
Inducible mouse line for cardiac NOX2 inhibition
This technology describes an inducible mouse line for the inhibition of cardiac-specific reactive oxygen species production.
16
AntioxidantAtherosclerosisCardiac muscle
John Morrow
Joan Martinez
Medicine
Columbia University Medical Center (CUMC)
2022-02-16
FixR: Late sodium current peptide inhibitor for treating cardiac arrhythmias
This technology, FixR, is a modified peptide and delivery system aimed at reducing pathogenic late sodium currents, which are implicated in cardiac and neurological diseases, including cardiac arrhythmia.
25
Adeno-associated virusArrhythmiaAutism spectrum
Manu Ben-JohnyNourdine Chakouri
Kristin Neuman
Physiology and Cellular Biophysics
Columbia University Medical Center (CUMC)
2021-10-12
Treatment of systolic heart failure without increased heart rate (tachycardia)
This technology is a small molecule protein therapeutic for systolic heart failure, which improves contractility without an unwanted rise in a patient’s heart rate.
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BiopharmaceuticalBlood pressureCardiac arrest
4
Alexander KushnirArianne PapaGuoxia Liu
Joan Martinez
CardiologyMedicinePhysiology and Cellular Biophysics
Columbia University Medical Center (CUMC)
2023-11-03
Sigma non-opioid receptor 1 agonist for the treatment for Timothy Syndrome
This technology is a set of small molecule agonists of the Sigma non-opioid receptor for the treatment of Timothy Syndrome.
10
Blood–brain barrierCalcium signalingCyclin-dependent kinase
4
Donald William Landry MD, Ph.D.Kirsten Alison RinderspacherMasayuki Yazawa Ph.D.
Kristin Neuman
MedicineRehabilitation & Regenerative Medicine
Columbia University Medical Center (CUMC)
2024-01-10
Cell-based model for early-onset restrictive cardiomyopathy (RCM)
This technology is a pluripotent stem cell derived cardiomyocyte model of early-onset restrictive cardiomyopathy (RCM) based on a mutation in Filamin C (FLNC) which can be harnessed to recapitulate RCM phenotypes and to screen and identify therapeutic compounds for RCM.
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Cardiac muscle cellCardiomyopathyDrug discovery
5
Barry FineBryan WangGordana Vunjak-Novakovic
Kristin Neuman
Biomedical EngineeringMedicineProgram in Cellular, Molecular, Structural and Genetic Studies
Columbia University Medical Center (CUMC)Faculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)
2023-11-10
Mouse model for ion channel disruption via TRIP8b disruption
This technology describes an inducible mouse line for the expression of unstable TRIP8b protein to study ion channel localization and function.
13
DendriteExonGene expression
Bina SantoroSteven A. Siegelbaum PhD
Jerry Kokoshka
CENTER OF NEUROBIOLOGY AND BEHAVIORPharmacology
Columbia University Medical Center (CUMC)
2023-05-02
Cardiac ablation monitoring with intracardiac echocardiography (ICE)
This technology is a method of monitoring catheter ablation of faulty electrical pathways in the myocardial tissue of the heart using ultrasound catheter-guided intracardiac echocardiography.
8
Cardiac muscleCatheterEchocardiography
Elisa KonofagouVincent Sayseng
Dovina Qu
Biomedical Engineering
Fu Foundation School of Engineering and Applied Science (SEAS)
2022-10-09
Growing heart valve prosthesis that mitigates need for repeat surgery
This technology is a hybrid regenerative prosthetic heart valve that can grow with the patient over time, eliminating the need for multiple valve replacement surgeries in pediatric patients.
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3D printingArtificial heart valveCardiac surgery
David Kalfa
Kristin Neuman
Surgery
Columbia University Medical Center (CUMC)
2021-01-05
Electromechanical wave imaging with automated activation mapping
This technology is an electromechanical wave imaging platform for non-invasive, automated generation of cardiac activation sequencing mapping.
7
Atrial fibrillationElectromechanicsHeart arrhythmia
Elisa KonofagouLea Melki
Dovina Qu
Biomedical Engineering
Fu Foundation School of Engineering and Applied Science (SEAS)
2020-09-14
Electrocardiogram-compatible deep learning algorithm for aortic stenosis detection
This technology is a diagnostic tool combining electrocardiography with the power of deep learning algorithms to detect moderate to severe aortic stenosis, aortic regurgitation, and mitral regurgitation.
10
Aortic regurgitationAortic stenosisDeep learning
Pierre EliasTimothy Joseph Poterucha
Joan Martinez
CardiologyMedicine
Columbia University Medical Center (CUMC)
2021-05-25
Catheter-based optical method for improving treatment of cardiac arrhythmias
This technology is a catheter-based optical method for ensuring proper catheter contact with cardiac tissue prior to radiofrequency ablation, in order to improve accuracy for cardiac arrhythmia treatment.
11
Atrial fibrillationCardiac muscleCatheter
Christine P. HendonMohammad ZaryabRajinder Singh-Moon
Dovina Qu
Electrical Engineering
Fu Foundation School of Engineering and Applied Science (SEAS)
2020-02-14
Mouse model for the PDGFRß specific expression of inducible Cre recombinase
This technology is a mouse model for the specific expression of tamoxifen-dependent Cre recombinase through the pericyte-specific PDGFR-beta promoter.
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AngiogenesisCarcinogenesisCre recombinase
Chyuan-Sheng Lin
Jerry Kokoshka
Opthamology
2017-09-25
Deep learning model for cardiac right ventricular volume quantification
This technology is an attention-based deep learning for cardiac right ventricular volume quantification using 2D echocardiography.
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Deep learningEchocardiographyMedical imaging
Archontis GiannakidisPolydoros Kampaktsis
Joan Martinez
Cardiology
Columbia University Medical Center (CUMC)
2024-01-19