Cardio - Columbia Technology Ventures

Nov 10, 2023 · This technology is a pluripotent stem cell derived cardiomyocyte model of early-onset restrictive cardiomyopathy (RCM) based on a mutation in Filamin C (FLNC) which can be harnessed to recapitulate RCM phenotypes and to screen and identify therapeutic compounds for RCM.

Inventors: Barry Fine, Bryan Wang, Gordana Vunjak-Novakovic, Trevor Ray Nash, Xiaokan Zhang

8Cardiac muscle cell Cardiomyopathy Drug discovery

Kristin Neuman

Biomedical Engineering Medicine Program in Cellular, Molecular, Structural and Genetic Studies

Columbia University Medical Center (CUMC)Faculty of the Arts & Sciences Fu Foundation School of Engineering and Applied Science (SEAS)

Treatment of systolic heart failure without increased heart rate (tachycardia)

CU19251

Nov 3, 2023 · This technology is a small molecule protein therapeutic for systolic heart failure, which improves contractility without an unwanted rise in a patient’s heart rate.

Inventors: Alexander Kushnir, Arianne Papa, Guoxia Liu, Steven Marx

13Biopharmaceutical Blood pressure Cardiac arrest

Joan Martinez

Cardiology Medicine Physiology and Cellular Biophysics

Columbia University Medical Center (CUMC)

Ubiquinone-based safe anesthetic and sedative agent

CU21133

Oct 31, 2023 · This technology is a new composition using ubiquinone as an anesthetic and sedative for clinical use.

Inventors: Richard J. Levy

21Anesthesia Anesthetic Cardiac muscle

Cynthia Lang

Anesthesiology

Columbia University Medical Center (CUMC)

Continuous, self-calibrating, cuffless, and non-invasive blood pressure monitor

CU19046

Oct 20, 2023 · This technology consists of a wearable wrist device that provides continuous blood pressure monitoring that is self-calibrating and utilizes a combination of positional sensors and machine-learning algorithms to adjust for changes in hydrostatic pressure due to arm movement.

Inventors: David Colburn, Samuel Sia Ph.D.

9Algorithm Ambulatory care Biometrics

Dovina Qu

Biomedical Engineering

Fu Foundation School of Engineering and Applied Science (SEAS)

Automated software tool for analysis of cardiac tissue function

CU23247

Jul 31, 2023 · This technology, BeatProfiler, is a desktop graphical-user-interface (GUI) that leverages deep learning for high-throughput, streamlined analysis of in vitro human cardiac cells and engineered tissues, primarily aimed at accelerating drug development and disease phenotyping in cardiovascular research.

Inventors: Gordana Vunjak-Novakovic, Kunlun Wang, Youngbin Kim

8Cardiovascular disease Deep learning Drug development

Cynthia Lang

Biomedical Engineering

Fu Foundation School of Engineering and Applied Science (SEAS)

Recombinant protein to treat inflammation

CU23248

May 10, 2023 · This technology is a protein for the treatment of cardiac and coronary artery inflammation that can be used as a potential therapeutic approach for vascular conditions like Kawasaki disease (KD) and immune mediated myocarditis.

Inventors: Mark Gorelik

14Anti-inflammatory Atherosclerosis Biomarker

Sara Gusik

Pediatrics/Rheumatology

Columbia University Medical Center (CUMC)

Mouse model for ion channel disruption via TRIP8b disruption

CU23232

May 2, 2023 · This technology describes an inducible mouse line for the expression of unstable TRIP8b protein to study ion channel localization and function.

Inventors: Bina Santoro, Steven A. Siegelbaum PhD

13Dendrite Exon Gene expression

Jerry Kokoshka

CENTER OF NEUROBIOLOGY AND BEHAVIOR Pharmacology

Columbia University Medical Center (CUMC)

Digital health enabled hybrid cardiac rehabilitation

CU23057

Feb 17, 2023 · This technology is a digital health model to improve access and adherence to cardiac rehabilitation by moving clinic-based treatment to the home.

Inventors: Andrea T. Duran

Data integration Telehealth

Sara Gusik

Medicine

Columbia University Medical Center (CUMC)

Cardiac ablation monitoring with intracardiac echocardiography (ICE)

CU19295

Oct 9, 2022 · This technology is a method of monitoring catheter ablation of faulty electrical pathways in the myocardial tissue of the heart using ultrasound catheter-guided intracardiac echocardiography.

Inventors: Elisa Konofagou, Vincent Sayseng

8Cardiac muscle Catheter Echocardiography

Dovina Qu

Biomedical Engineering

Fu Foundation School of Engineering and Applied Science (SEAS)

Cardiac tissue platform for diagnosing myocarditis

CU21222

Jun 10, 2022 · This technology is an in vitro human cardiac muscle tissue platform that can be used to diagnose myocarditis.

Inventors: Gordana Vunjak-Novakovic, Laura Geraldino Pardilla, Manuel Alejandro Tamargo, Robert Winchester, Sharon Fleischer, Trevor Ray Nash

18Asymptomatic Autoantibody Autoimmune disease

Cynthia Lang

Biomedical Engineering Medicine

Columbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)

Inducible mouse line for cardiac NOX2 inhibition

CU22219

Feb 16, 2022 · This technology describes an inducible mouse line for the inhibition of cardiac-specific reactive oxygen species production.

Inventors: John Morrow

16Antioxidant Atherosclerosis Cardiac muscle

Joan Martinez

Medicine

Columbia University Medical Center (CUMC)

FixR: Late sodium current peptide inhibitor for treating cardiac arrhythmias

CU22077

Oct 12, 2021 · This technology, FixR, is a modified peptide and delivery system aimed at reducing pathogenic late sodium currents, which are implicated in cardiac and neurological diseases, including cardiac arrhythmia.

Inventors: Manu Ben-Johny, Nourdine Chakouri

16Calmodulin Cardiac arrest Cardiac muscle cell

Kristin Neuman

Physiology and Cellular Biophysics

Columbia University Medical Center (CUMC)

Electrocardiogram-compatible deep learning algorithm for aortic stenosis detection

CU21335

May 25, 2021 · This technology is a diagnostic tool combining electrocardiography with the power of deep learning algorithms to detect moderate to severe aortic stenosis, aortic regurgitation, and mitral regurgitation.

Inventors: Pierre Elias, Timothy Joseph Poterucha

11Algorithm Aortic insufficiency Aortic stenosis

Sara Gusik

Cardiology Medicine

Columbia University Medical Center (CUMC)