Cardiovascular

This technology is a method and computer-accessible medium for determining catheter contact orientation with optical coherence tomography (OCT) for direct visualization of surfaces during radiofrequency ablation (RFA) therapy.

This technology consists of a wearable wrist device that provides continuous blood pressure monitoring that is self-calibrating and utilizes a combination of positional sensors and machine-learning algorithms to adjust for changes in hydrostatic pressure due to arm movement.

This technology describes an inducible mouse line for the inhibition of cardiac-specific reactive oxygen species production.

This technology, FixR, is a modified peptide and delivery system aimed at reducing pathogenic late sodium currents, which are implicated in cardiac and neurological diseases, including cardiac arrhythmia.

This technology is a small molecule protein therapeutic for systolic heart failure, which improves contractility without an unwanted rise in a patient’s heart rate.

This technology is a platform to preserve, rehabilitate, and store living heart valves for the off-the-shelf availability of a heart valve replacement capable of growth and self-repair, thereby overcoming the current standard of multiple reoperations and reinterventions.

This technology is a set of small molecule agonists of the Sigma non-opioid receptor for the treatment of Timothy Syndrome.

This technology is a pluripotent stem cell derived cardiomyocyte model of early-onset restrictive cardiomyopathy (RCM) based on a mutation in Filamin C (FLNC) which can be harnessed to recapitulate RCM phenotypes and to screen and identify therapeutic compounds for RCM.

This technology describes an inducible mouse line for the expression of unstable TRIP8b protein to study ion channel localization and function.

This technology is a method of monitoring catheter ablation of faulty electrical pathways in the myocardial tissue of the heart using ultrasound catheter-guided intracardiac echocardiography.

This technology is a hybrid regenerative prosthetic heart valve that can grow with the patient over time, eliminating the need for multiple valve replacement surgeries in pediatric patients.

This technology is an electromechanical wave imaging platform for non-invasive, automated generation of cardiac activation sequencing mapping.

This technology, called Genetically Encoded Enhancer of Ca2+ Currents (GEECC), is a genetically encoded enhancer of calcium currents to directly modulate calcium currents in L-type Ca2+ channels.

This technology is a diagnostic tool combining electrocardiography with the power of deep learning algorithms to detect moderate to severe aortic stenosis, aortic regurgitation, and mitral regurgitation.

This technology is a catheter-based optical method for ensuring proper catheter contact with cardiac tissue prior to radiofrequency ablation, in order to improve accuracy for cardiac arrhythmia treatment.