Columbia Technology Ventures

Genomics & Multi-Omics

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Chimeric CRISPR-associated transposon system for RNA-mediated DNA integration
This technology is a chimeric CRISPR-associated transposon (CAST) system that allows for more efficient and specific RNA-guided DNA integration.
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CoevolutionDNA repairEnzyme
George Davis LampeSamuel H. Sternberg
Cynthia Lang
Biochemistry & Molecular Biophysics
Columbia University Medical Center (CUMC)
2026-01-09
Microfluidic platform for large-scale single-cell sequencing and imaging
This technology is a platform for high-throughput single-cell RNA sequencing and imaging that combines a highly scalable microfluidic platform and imaging based on optical cell-identifying barcodes.
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Brain mappingCell cultureDrug discovery
Jinzhou YuanPeter A. SimsSayantan Bose
Cynthia Lang
Biochemistry & Molecular BiophysicsSystems Biology
Columbia University Medical Center (CUMC)
2025-01-02
Optical in situ nucleotide sequence detection using combinatorial hybridization
This technology is a method for optical in situ nucleotide sequence detection using combinatorial hybridization.
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Breast cancerCRISPRCohort study
Jellert Gaublomme
Joan Martinez
Biological Sciences
Faculty of the Arts & Sciences
2026-01-29
High-throughput single-cell multi-omics platform for integrated RNA, DNA, and protein analysis
This technology is a high-throughput single-cell multi-omics platform that integrates RNA, DNA, and protein analysis to enable comprehensive cellular profiling.
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BiomarkerCell nucleusDrug discovery
Peter A. SimsTimothy R. Olsen
Cynthia Lang
Biochemistry & Molecular BiophysicsSystems Biology
Columbia University Medical Center (CUMC)
2025-01-02
Programmable CRISPR-transposon platform for targeted DNA insertion
This technology is an engineered CRISPR-associated transposon (CRISPR-CAST) platform that enables programmable, cut-free insertion of DNA into specific sites on the genome, allowing precise and efficient gene modification or payload integration in living cells.
GenomeTransposable element
George Davis LampeSamuel H. Sternberg
Cynthia Lang
Biochemistry & Molecular Biophysics
Columbia University Medical Center (CUMC)
2026-01-09
CRISPR-transposon platform for programmable DNA integration
This technology is an RNA-guided genome engineering platform that enables precise, site-specific DNA integration and endogenous protein tagging without introducing double-strand breaks.
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DNA repairEndogenous retrovirusGene
Samuel H. Sternberg
Cynthia Lang
Biochemistry & Molecular Biophysics
Columbia University Medical Center (CUMC)
2026-01-09
Evolved CRISPR-associated transposase systems for genome engineering
This technology is an evolved CRISPR-associated transposase system that facilitates highly efficient programmable DNA insertions in human cells without relying on homologous repair and double strand breaks.
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CRISPRFibroblastGenetically modified animal
Samuel H. SternbergSanne Klompe
Cynthia Lang
Biochemistry & Molecular BiophysicsChemistry
Columbia University Medical Center (CUMC)Faculty of the Arts & Sciences
2025-12-18
Improved specificity of CRISPR-associated transposon (CAST) systems
This technology is a genome engineering platform that enhances the specificity of CRISPR-associated transposase (CAST)-mediated DNA integration by modulating transposon protein activity to minimize off-target insertions.
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BiopharmaceuticalCRISPRDNA repair
Jerrin Thomas GeorgeSamuel H. Sternberg
Cynthia Lang
Biochemistry & Molecular Biophysics
Columbia University Medical Center (CUMC)
2026-01-09
Nucleic acid-guided DNA synthesis with reverse transcriptases
This technology is a system for guided DNA synthesis with high efficiency and minimal byproducts.
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Antiviral drugGenomeGenome editing
Samuel H. SternbergStephen Tang
Cynthia Lang
Biochemistry & Molecular Biophysics
Columbia University Medical Center (CUMC)
2026-01-09