Transgenic Mouse for Studying Embryogenetic Significance of RGS Domain on Axin2991A mutant mouse lacking Axin’s RGS domain reveals its essential role in normal embryogenesis via Wnt signaling disruption.TagsEmbryonic developmentGeneIntravenous therapyInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-26
Transgenic mouse strain allows inducible genetic expression in kidney cells and nervous systemCU14313Inducible kidney and nervous system-specific gene edits in mice via GDNF-driven CreERT2, enabling precise temporal control.TagsComplementary DNACre recombinaseEnteric nervous systemInventorsFranklin David Costantini Ph.D.Cristina CebriaNaoya AsaiManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2014-08-25
Form 1 Axin Knockin Mouse for Studying Functional Equivalence of Axin and Axin22988A genetically engineered mouse tests functional equivalence of Axin and Axin2, revealing non-redundant roles and isoform-specific insights.TagsAlleleBirth weightComplementary DNAInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Mutant Mouse with Modified Axin Gene for Studying Embryogenetic Significance of Protein-Binding Domains2995Mutant mouse lacking Axin’s six C-terminal amino acids reveals indispensable domain for normal embryogenesis; aids Wnt research.TagsAmino acidC-terminusEmbryonic developmentInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Ret-Men2B Mouse Model for Investigation of Pheochromocytoma Linked Endocrine Tumors2994Transgenic Ret M918T mouse model reveals MEN2B mechanisms, enabling rapid study of pheochromocytoma development and Ret signaling.TagsEndocrine systemEnteric nervous systemGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Axin and Axin2 Studied in Mutant Mouse for Functional Equivalence2989Axin and Axin2 show largely equivalent in vivo function; mutant mice reveal shared Wnt pathway roles and cancer relevance.TagsAlleleBirth weightComplementary DNAInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
VPS26aTg (Hbeta58) Cos Mouse Model for the Investigation of Alzheimer's Disease2997Transgenic mice with Hbeta58 mutation model retromer-related amyloid trafficking to study Alzheimer’s disease mechanisms.TagsAmyloidBrainDementiaInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-10-31
Mouse Model as a Tool for Spatiotemporal and Lineage-Specific Gene Expression2998Transgenic mice enabling tissue-, time-, and lineage-specific gene expression via Cre-loxP and rtTA/tet systems for precise studies.TagsCre recombinaseDoxycyclineGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-26
Mouse Model, Ret-S697A for Enteric Nervous System Function and Development Investigation2993Transgenic Ret S697A mice reveal Ret signaling's crucial role in enteric nervous system development and ENCC migration.TagsChemotaxisEnteric nervous systemGastrointestinal tractInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Tetracycline-Controlled System for Targeted Gene Expression in Axin2-Expressing Cells2987Targeted, tetracycline-controlled gene expression in Axin2-expressing cells enables temporal-spatial studies of Wnt signaling in neural development.TagsDevelopment of the nervous systemEmbryonic developmentGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Transgenic Mouse Strain for Visualization of Epithelial Cells during Renal Development2986Transgenic mouse reveals epithelial cell membrane shapes during ureteric bud morphogenesis using myr-Venus fluorescence.TagsConfocal microscopyCytoplasmEmbryonic developmentInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Mouse Model for Investigation of the Function of the Potentially Cancer Causing Ret Proto-Oncogene2996Engineered mice explore Ret9 proto-oncogene signaling; dissects PDZ motif roles, aiding cancer research and targeted therapies.TagsC-terminusEnteric nervous systemGeneInventorsFranklin David Costantini Ph.D.ManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-08-23
Mouse for cell lineage tracing in living tissue2711Cre-reporter mouse enables real-time, inducible cell lineage tracing in living tissue via YFP at ROSA26 locus.TagsCre recombinaseGene expressionGenetic recombinationInventorsFranklin David Costantini Ph.D.Shankar SrinivasManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-05-09
Altering Mouse Genome with pBigT Plasmid2446A plasmid-based method (pBigT) enables streamlined creation of transgenic mice with targeted ROSA26 genome integration.TagsAdenoviridaeBase pairCre recombinaseInventorsFranklin David Costantini Ph.D.Shankar SrinivasManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-05-12
Plasmid for mouse ROSA26 locus for use with plasmid pBigT2445Plasmid toolkit targets mouse ROSA26 locus with pBigT for Cre reporters, enabling GFP tagging and lineage tracing.TagsCre recombinaseDNA ligaseDNA sequencingInventorsFranklin David Costantini Ph.D.Shankar SrinivasManagerSara GusikDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2011-05-12
