Inventors
Franklin David Costantini Ph.D.
View all technologies
Transgenic Mouse for Studying Embryogenetic Significance of RGS Domain on Axin
2991
A mutant mouse lacking Axin’s RGS domain reveals its essential role in normal embryogenesis via Wnt signaling disruption.
Tags
Embryonic development
Gene
Intravenous therapy
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-26
Transgenic mouse strain allows inducible genetic expression in kidney cells and nervous system
CU14313
Inducible kidney and nervous system-specific gene edits in mice via GDNF-driven CreERT2, enabling precise temporal control.
Tags
Complementary DNA
Cre recombinase
Enteric nervous system
Inventors
Franklin David Costantini Ph.D.
Cristina Cebria
Naoya Asai
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2014-08-25
Form 1 Axin Knockin Mouse for Studying Functional Equivalence of Axin and Axin2
2988
A genetically engineered mouse tests functional equivalence of Axin and Axin2, revealing non-redundant roles and isoform-specific insights.
Tags
Allele
Birth weight
Complementary DNA
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Mutant Mouse with Modified Axin Gene for Studying Embryogenetic Significance of Protein-Binding Domains
2995
Mutant mouse lacking Axin’s six C-terminal amino acids reveals indispensable domain for normal embryogenesis; aids Wnt research.
Tags
Amino acid
C-terminus
Embryonic development
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Ret-Men2B Mouse Model for Investigation of Pheochromocytoma Linked Endocrine Tumors
2994
Transgenic Ret M918T mouse model reveals MEN2B mechanisms, enabling rapid study of pheochromocytoma development and Ret signaling.
Tags
Endocrine system
Enteric nervous system
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Axin and Axin2 Studied in Mutant Mouse for Functional Equivalence
2989
Axin and Axin2 show largely equivalent in vivo function; mutant mice reveal shared Wnt pathway roles and cancer relevance.
Tags
Allele
Birth weight
Complementary DNA
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
VPS26aTg (Hbeta58) Cos Mouse Model for the Investigation of Alzheimer's Disease
2997
Transgenic mice with Hbeta58 mutation model retromer-related amyloid trafficking to study Alzheimer’s disease mechanisms.
Tags
Amyloid
Brain
Dementia
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-10-31
Mouse Model as a Tool for Spatiotemporal and Lineage-Specific Gene Expression
2998
Transgenic mice enabling tissue-, time-, and lineage-specific gene expression via Cre-loxP and rtTA/tet systems for precise studies.
Tags
Cre recombinase
Doxycycline
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-26
Mouse Model, Ret-S697A for Enteric Nervous System Function and Development Investigation
2993
Transgenic Ret S697A mice reveal Ret signaling's crucial role in enteric nervous system development and ENCC migration.
Tags
Chemotaxis
Enteric nervous system
Gastrointestinal tract
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Tetracycline-Controlled System for Targeted Gene Expression in Axin2-Expressing Cells
2987
Targeted, tetracycline-controlled gene expression in Axin2-expressing cells enables temporal-spatial studies of Wnt signaling in neural development.
Tags
Development of the nervous system
Embryonic development
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Transgenic Mouse Strain for Visualization of Epithelial Cells during Renal Development
2986
Transgenic mouse reveals epithelial cell membrane shapes during ureteric bud morphogenesis using myr-Venus fluorescence.
Tags
Confocal microscopy
Cytoplasm
Embryonic development
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Mouse Model for Investigation of the Function of the Potentially Cancer Causing Ret Proto-Oncogene
2996
Engineered mice explore Ret9 proto-oncogene signaling; dissects PDZ motif roles, aiding cancer research and targeted therapies.
Tags
C-terminus
Enteric nervous system
Gene
Inventors
Franklin David Costantini Ph.D.
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-08-23
Mouse for cell lineage tracing in living tissue
2711
Cre-reporter mouse enables real-time, inducible cell lineage tracing in living tissue via YFP at ROSA26 locus.
Tags
Cre recombinase
Gene expression
Genetic recombination
Inventors
Franklin David Costantini Ph.D.
Shankar Srinivas
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-05-09
Altering Mouse Genome with pBigT Plasmid
2446
A plasmid-based method (pBigT) enables streamlined creation of transgenic mice with targeted ROSA26 genome integration.
Tags
Adenoviridae
Base pair
Cre recombinase
Inventors
Franklin David Costantini Ph.D.
Shankar Srinivas
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-05-12
Plasmid for mouse ROSA26 locus for use with plasmid pBigT
2445
Plasmid toolkit targets mouse ROSA26 locus with pBigT for Cre reporters, enabling GFP tagging and lineage tracing.
Tags
Cre recombinase
DNA ligase
DNA sequencing
Inventors
Franklin David Costantini Ph.D.
Shankar Srinivas
Manager
Sara Gusik
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2011-05-12
