Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung diseaseCU23307Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.TagsBiomimeticsBioreactorCell cultureInventorsGordana Vunjak-NovakovicJinho KimKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08
Engineered model of human bone marrow for diagnosis and prediction of cancer metastasisCU23273Engineered patient-specific bone marrow model predicts cancer metastasis, metastasis progression, and treatment response non-invasively.TagsAssayAutoimmune diseaseBone marrowInventorsGordana Vunjak-NovakovicDaniel Naveed TavakolPamela GraneyManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-04-08CollectionsOncologyPlatform/Research ToolMedical Device
Bioengineered human bone marrow model for drug discoveryCU22388Engineered 3D human bone marrow from iPSCs enables personalized, in vitro drug screening for hematologic diseases and toxicity.TagsAnemiaBone marrowCrosstalkInventorsGordana Vunjak-NovakovicAdolfo A. Ferrando M.D., Ph.D.Daniel Naveed TavakolManagerCynthia LangDepartmentsBiomedical EngineeringInstitute for Cancer GeneticsPediatricsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-02-27CollectionsOncology
Preconditioning cell treatment for immunotherapyCU17038Dual hypoxia and inflammatory cytokine preconditioning boosts mesenchymal stem cells’ immunosuppressive potency for more effective immunotherapies.TagsAutoimmune diseaseCoronary artery diseaseCytokineInventorsGordana Vunjak-NovakovicHolly WobmaMariko KanaiManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-06-03
Real-time in situ measurement of electrical impedance of lung tissueCU22293Real-time in situ airway impedance device assesses epithelial health, enabling rapid COPD, asthma, and lung disease monitoring.TagsAsthmaBiomarkerCystic fibrosisInventorsGordana Vunjak-NovakovicJiawen ChenJinho KimManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-05-29
Modular, multi-tissue system for in vitro modeling of systemic diseaseCU19102Multi-tissue organ-on-a-chip platform enables vascular-coupled, patient-specific modeling of systemic disease and cancer metastasis.TagsCirculatory systemCrosstalkEndotheliumInventorsGordana Vunjak-NovakovicAlan ChramiecAndrea Califano Ph.D.ManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-10-31CollectionsOncologyPlatform/Research Tool
Modular human body-on-a-chip platformCU18367Modular organ-on-a-chip platform enabling multi-tissue cultures from a single stem line, non-PDMS, personalized, cost-efficient drug testing.TagsBiocompatibilityBiomaterialBiomimeticsInventorsGordana Vunjak-NovakovicKacey RonaldsonKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-03-05CollectionsCNS/NeurologyPlatform/Research Tool
Three-dimensional bone scaffold for modeling cancersCU140103D decellularized bone scaffold models tumor microenvironment for high-throughput cancer drug screening and personalized therapy.TagsAssayBiomechanicsBone tumorInventorsGordana Vunjak-NovakovicAranzazu VillasanteManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2013-12-20
Semi-automated optogenetic platform for evaluation of human neuromuscular functionalityCU18400Semi-automated optogenetic platform assesses patient-derived neuromuscular function for MG diagnosis and disease monitoring.TagsDigital image processingDrug discoveryHigh-throughput screeningInventorsGordana Vunjak-NovakovicOlaia Fernandez VilaStephen Parnell MaManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-12-24CollectionsPlatform/Research ToolMedical Device
Preservation, rehabilitation, and storage of living allogenic heart valves capable of growth and self-repairCU23233Living, growth-capable heart valve biobank enables off-the-shelf, rehabilitated allografts with growth and self-repair potential.TagsAllotransplantationBiobankBioreactorInventorsGordana Vunjak-NovakovicDavid KalfaElizabeth CordovesManagerKristin NeumanDepartmentsBiomedical EngineeringPathology & Cell BiologySurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-12CollectionsCardiovascular
Cell-based model for early-onset restrictive cardiomyopathy (RCM)CU22246Patient-derived iPSC heart tissue model reproduces FLNC-linked RCM for drug screening and therapy discovery.TagsCardiac muscle cellCardiomyopathyDrug discoveryInventorsGordana Vunjak-NovakovicBarry FineBryan WangManagerKristin NeumanDepartmentsBiomedical EngineeringMedicineProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-11-10CollectionsCardiovascular
Tubular scaffolds for vascular tissue engineeringCU15309Rapid, precise biopolymer microtubes with tunable fiber alignment enable vascular grafts, nerve guides, and model vessels.TagsAcidBiomaterialBiopolymerInventorsGordana Vunjak-NovakovicChristopher CannizzaroDavid L. KaplanManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-03-12
Multilayered biocompatible and loadable bio-sealant for pulmonary air leaksCU17095Biocompatible, multilayer lung sealant combining ECM hydrogel and porous patch to seal pulmonary leaks and support healing.TagsExtracellular matrixGastrointestinal tractHydrogelInventorsGordana Vunjak-NovakovicBrandon GuenthartJinho KimManagerCynthia LangDepartmentsBiomedical EngineeringMechanical EngineeringSurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-02-15
Sorting of extracellular vesicles for precise, cell-specific diagnosticsCU19242Sorting extracellular vesicles by parent cell type enables precise, non-invasive, multi-organ diagnostics from a single blood sample.TagsAssayCardiac muscleCellular differentiationInventorsGordana Vunjak-NovakovicBohao LiuBryan WangManagerCynthia LangDepartmentsBiomedical EngineeringProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsFaculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2020-01-13CollectionsPlatform/Research ToolMedical Device
Cardiac tissue platform for diagnosing myocarditisCU21222Non-invasive engineered human cardiac tissue platform diagnosing myocarditis via serum-induced changes in contractility, calcium handling, and force.TagsAntibodyAutoimmune diseaseBlood testInventorsGordana Vunjak-NovakovicLaura Geraldino PardillaManuel Alejandro TamargoManagerCynthia LangDepartmentsBiomedical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2022-06-10CollectionsPlatform/Research ToolMedical DeviceCardiovascular
Bioreactor for high-throughput production and mechanical stimulation of cardiac microtissuesCU17293Microfluidic bioreactor enables high-throughput, mechanically stimulated cardiac microtissues for mature, hypertrophy-relevant in vitro studies.TagsBioreactorCardiac muscleHeart failureInventorsGordana Vunjak-NovakovicHesam ParsaManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-07-02CollectionsCardiovascular
Functional recovery of human donor lungs for transplantationCU13138Localized regional lung regeneration preserves vasculature to revive rejected donor lungs for transplantation.TagsDrug discoveryEx vivoExtracellular matrixInventorsGordana Vunjak-NovakovicDonald FreytesGopal SinghManagerCynthia LangDepartmentsBiomedical EngineeringBiomedical InformaticsSurgeryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-11-20
Extracellular vesicle-based assay for detecting head and neck cancerCU21332Noninvasive chip assay detects tumor-enriched proteins on patient extracellular vesicles to screen and monitor head-and-neck cancer.TagsAssayBody fluidCancer stagingInventorsGordana Vunjak-NovakovicAkiva MintzFatemeh Momen-HeraviManagerJoan MartinezDepartmentsBiomedical EngineeringCollege of Dental MedicineRadiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-06-28CollectionsOncology
High-throughput bioreactor for preparing multiple interacting microtissuesCU17074High-throughput bioreactor enables multi-tissue microtissue growth in 24–96 well formats for drug screening and disease modeling.TagsBioreactorGene regulatory networkHigh-throughput screeningInventorsGordana Vunjak-NovakovicKacey RonaldsonKeith YeagerManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-02-08
Automated software tool for analysis of cardiac tissue functionCU23247BeatProfiler automates multimodal cardiac tissue analysis with a standalone GUI, using deep learning for high-throughput, actionable insights.TagsCardiovascular diseaseDrug developmentHigh-throughput screeningInventorsGordana Vunjak-NovakovicKunlun WangYoungbin KimManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-07-31CollectionsMedical DeviceCardiovascularDigital Health (Software, AI, bioinformatics, etc)
Targeted drug delivery to diseased lung tissueCU16203Image-guided, steerable lung catheter delivers targeted liquid therapies to distal alveoli, reducing doses and side effects.TagsAcute respiratory distress syndromeArtificial intelligenceBiopsyInventorsGordana Vunjak-NovakovicJinho KimJohn O'NeillManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-02-23
Method of determining cell chirality for disease detection2959Automated, high-throughput chirality analysis on micropatterned cells enables disease detection and drug screening via phase-contrast imaging.TagsAlgorithmAssayAsymmetryInventorsGordana Vunjak-NovakovicQun WanManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-12-08
