Inventors
Gordana Vunjak-Novakovic
View all technologies
Small scale screening bioreactor with airway tissues and mucosa for the progression and treatment of lung disease
CU23307
Bioreactor recreating mucus-lined airways ex vivo for real-time, high-throughput modeling and therapeutic screening.
Tags
Biomimetics
Bioreactor
Cell culture
Inventors
Gordana Vunjak-Novakovic
Jinho Kim
Keith Yeager
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-04-08
Engineered model of human bone marrow for diagnosis and prediction of cancer metastasis
CU23273
Engineered patient-specific bone marrow model predicts cancer metastasis, metastasis progression, and treatment response non-invasively.
Tags
Assay
Autoimmune disease
Bone marrow
Inventors
Gordana Vunjak-Novakovic
Daniel Naveed Tavakol
Pamela Graney
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-04-08
Collections
Oncology
Platform/Research Tool
Medical Device
Bioengineered human bone marrow model for drug discovery
CU22388
Engineered 3D human bone marrow from iPSCs enables personalized, in vitro drug screening for hematologic diseases and toxicity.
Tags
Anemia
Bone marrow
Crosstalk
Inventors
Gordana Vunjak-Novakovic
Adolfo A. Ferrando M.D., Ph.D.
Daniel Naveed Tavakol
Manager
Cynthia Lang
Departments
Biomedical Engineering
Institute for Cancer Genetics
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-02-27
Collections
Oncology
Preconditioning cell treatment for immunotherapy
CU17038
Dual hypoxia and inflammatory cytokine preconditioning boosts mesenchymal stem cells’ immunosuppressive potency for more effective immunotherapies.
Tags
Autoimmune disease
Coronary artery disease
Cytokine
Inventors
Gordana Vunjak-Novakovic
Holly Wobma
Mariko Kanai
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-06-03
Real-time in situ measurement of electrical impedance of lung tissue
CU22293
Real-time in situ airway impedance device assesses epithelial health, enabling rapid COPD, asthma, and lung disease monitoring.
Tags
Asthma
Biomarker
Cystic fibrosis
Inventors
Gordana Vunjak-Novakovic
Jiawen Chen
Jinho Kim
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-05-29
Modular, multi-tissue system for
in vitro
modeling of systemic disease
CU19102
Multi-tissue organ-on-a-chip platform enables vascular-coupled, patient-specific modeling of systemic disease and cancer metastasis.
Tags
Circulatory system
Crosstalk
Endothelium
Inventors
Gordana Vunjak-Novakovic
Alan Chramiec
Andrea Califano Ph.D.
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-10-31
Collections
Oncology
Platform/Research Tool
Modular human body-on-a-chip platform
CU18367
Modular organ-on-a-chip platform enabling multi-tissue cultures from a single stem line, non-PDMS, personalized, cost-efficient drug testing.
Tags
Biocompatibility
Biomaterial
Biomimetics
Inventors
Gordana Vunjak-Novakovic
Kacey Ronaldson
Keith Yeager
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-03-05
Collections
CNS/Neurology
Platform/Research Tool
Three-dimensional bone scaffold for modeling cancers
CU14010
3D decellularized bone scaffold models tumor microenvironment for high-throughput cancer drug screening and personalized therapy.
Tags
Assay
Biomechanics
Bone tumor
Inventors
Gordana Vunjak-Novakovic
Aranzazu Villasante
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2013-12-20
Semi-automated optogenetic platform for evaluation of human neuromuscular functionality
CU18400
Semi-automated optogenetic platform assesses patient-derived neuromuscular function for MG diagnosis and disease monitoring.
Tags
Digital image processing
Drug discovery
High-throughput screening
Inventors
Gordana Vunjak-Novakovic
Olaia Fernandez Vila
Stephen Parnell Ma
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-12-24
Collections
Platform/Research Tool
Medical Device
Preservation, rehabilitation, and storage of living allogenic heart valves capable of growth and self-repair
CU23233
Living, growth-capable heart valve biobank enables off-the-shelf, rehabilitated allografts with growth and self-repair potential.
Tags
Allotransplantation
Biobank
Bioreactor
Inventors
Gordana Vunjak-Novakovic
David Kalfa
Elizabeth Cordoves
Manager
Kristin Neuman
Departments
Biomedical Engineering
Pathology & Cell Biology
Surgery
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-12-12
Collections
Cardiovascular
Cell-based model for early-onset restrictive cardiomyopathy (RCM)
CU22246
Patient-derived iPSC heart tissue model reproduces FLNC-linked RCM for drug screening and therapy discovery.
Tags
Cardiac muscle cell
Cardiomyopathy
Drug discovery
Inventors
Gordana Vunjak-Novakovic
Barry Fine
Bryan Wang
Manager
Kristin Neuman
Departments
Biomedical Engineering
Medicine
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-11-10
Collections
Cardiovascular
Tubular scaffolds for vascular tissue engineering
CU15309
Rapid, precise biopolymer microtubes with tunable fiber alignment enable vascular grafts, nerve guides, and model vessels.
Tags
Acid
Biomaterial
Biopolymer
Inventors
Gordana Vunjak-Novakovic
Christopher Cannizzaro
David L. Kaplan
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-03-12
Multilayered biocompatible and loadable bio-sealant for pulmonary air leaks
CU17095
Biocompatible, multilayer lung sealant combining ECM hydrogel and porous patch to seal pulmonary leaks and support healing.
Tags
Extracellular matrix
Gastrointestinal tract
Hydrogel
Inventors
Gordana Vunjak-Novakovic
Brandon Guenthart
Jinho Kim
Manager
Cynthia Lang
Departments
Biomedical Engineering
Mechanical Engineering
Surgery
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-02-15
Sorting of extracellular vesicles for precise, cell-specific diagnostics
CU19242
Sorting extracellular vesicles by parent cell type enables precise, non-invasive, multi-organ diagnostics from a single blood sample.
Tags
Assay
Cardiac muscle
Cellular differentiation
Inventors
Gordana Vunjak-Novakovic
Bohao Liu
Bryan Wang
Manager
Cynthia Lang
Departments
Biomedical Engineering
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2020-01-13
Collections
Platform/Research Tool
Medical Device
Cardiac tissue platform for diagnosing myocarditis
CU21222
Non-invasive engineered human cardiac tissue platform diagnosing myocarditis via serum-induced changes in contractility, calcium handling, and force.
Tags
Antibody
Autoimmune disease
Blood test
Inventors
Gordana Vunjak-Novakovic
Laura Geraldino Pardilla
Manuel Alejandro Tamargo
Manager
Cynthia Lang
Departments
Biomedical Engineering
Medicine
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2022-06-10
Collections
Platform/Research Tool
Medical Device
Cardiovascular
Bioreactor for high-throughput production and mechanical stimulation of cardiac microtissues
CU17293
Microfluidic bioreactor enables high-throughput, mechanically stimulated cardiac microtissues for mature, hypertrophy-relevant in vitro studies.
Tags
Bioreactor
Cardiac muscle
Heart failure
Inventors
Gordana Vunjak-Novakovic
Hesam Parsa
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-07-02
Collections
Cardiovascular
Functional recovery of human donor lungs for transplantation
CU13138
Localized regional lung regeneration preserves vasculature to revive rejected donor lungs for transplantation.
Tags
Drug discovery
Ex vivo
Extracellular matrix
Inventors
Gordana Vunjak-Novakovic
Donald Freytes
Gopal Singh
Manager
Cynthia Lang
Departments
Biomedical Engineering
Biomedical Informatics
Surgery
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-11-20
Extracellular vesicle-based assay for detecting head and neck cancer
CU21332
Noninvasive chip assay detects tumor-enriched proteins on patient extracellular vesicles to screen and monitor head-and-neck cancer.
Tags
Assay
Body fluid
Cancer staging
Inventors
Gordana Vunjak-Novakovic
Akiva Mintz
Fatemeh Momen-Heravi
Manager
Joan Martinez
Departments
Biomedical Engineering
College of Dental Medicine
Radiology
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-06-28
Collections
Oncology
High-throughput bioreactor for preparing multiple interacting microtissues
CU17074
High-throughput bioreactor enables multi-tissue microtissue growth in 24–96 well formats for drug screening and disease modeling.
Tags
Bioreactor
Gene regulatory network
High-throughput screening
Inventors
Gordana Vunjak-Novakovic
Kacey Ronaldson
Keith Yeager
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-02-08
Automated software tool for analysis of cardiac tissue function
CU23247
BeatProfiler automates multimodal cardiac tissue analysis with a standalone GUI, using deep learning for high-throughput, actionable insights.
Tags
Cardiovascular disease
Drug development
High-throughput screening
Inventors
Gordana Vunjak-Novakovic
Kunlun Wang
Youngbin Kim
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-07-31
Collections
Medical Device
Cardiovascular
Digital Health (Software, AI, bioinformatics, etc)
Targeted drug delivery to diseased lung tissue
CU16203
Image-guided, steerable lung catheter delivers targeted liquid therapies to distal alveoli, reducing doses and side effects.
Tags
Acute respiratory distress syndrome
Artificial intelligence
Biopsy
Inventors
Gordana Vunjak-Novakovic
Jinho Kim
John O'Neill
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2018-02-23
Method of determining cell chirality for disease detection
2959
Automated, high-throughput chirality analysis on micropatterned cells enables disease detection and drug screening via phase-contrast imaging.
Tags
Algorithm
Assay
Asymmetry
Inventors
Gordana Vunjak-Novakovic
Qun Wan
Manager
Cynthia Lang
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-12-08
