Method to target T cell regulatory pathways for treatment of immunological diseases1779-aTargeting HLA-E restricted CD8+ T cells to induce self-tolerance, treating autoimmunity without compromising pathogen defense.TagsAntigenAutoimmune diseaseCytotoxic T cellInventorsHong JiangLeonard Chess MDManagerOfra WeinbergerDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-09-28
Methods to Activate or Block the HLA-E/Qa-1 Restricted CD8+ T Cell Mediated Regulatory Pathway in Treatment and Prevention of Immunological Disorders: Auto-Immune Disease, Infectious Disease, Organ Transplantation, or Tumor1979New Qa-1/HLA-E CD8+ T cell regulatory pathway approach enables targeted tolerance to autoimmunity, transplants, infections, and tumors.TagsAntigenAutoimmunityCognateInventorsHong JiangLeonard Chess MDManagerOfra WeinbergerDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2006-04-25
Computational methods for assessing and optimizing the protein expression potential of gene sequences in vivoCU12083Computationally optimize gene mRNA folding to boost in vivo protein expression, reducing costs via improved translation efficiency.TagsBiochemistryBiotechnologyData setInventorsDaniel AalbertsGregory BoelGuy MontelioneManagerOfra WeinbergerDepartmentsBiological SciencesNortheast Structural Genomics ConsortiumPhysicsDivisionsAdministrative Services Bldg.Faculty of the Arts & SciencesRelease Date2015-03-10
Targeted Mutagenesis and Codon Selection Techniques to Improve Protein Expression and SolubilityM10-014Codon-optimization algorithm boosts protein expression and solubility without altering sequence, enabling cost-effective industrial production.TagsAlgorithmAmino acidBig dataInventorsGregory BoelGuy MontelioneHelen NeelyManagerOfra WeinbergerDepartmentsBiological SciencesNortheast Structural Genomics ConsortiumDivisionsAdministrative Services Bldg.Faculty of the Arts & SciencesRelease Date2014-07-08
Engineering surface epitopes for improving protein crystallizationM08-082Engineers protein surfaces with epitopes via mutations to boost crystallization success for high-resolution structure determination.TagsAlgorithmDatabaseEpitopeInventorsJohn F. HuntWilliam Nicholson Price IIManagerOfra WeinbergerDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2008-04-07
BulkArg: computational pipeline for improving protein crystallization propensityCU23101A computational pipeline suggesting lysine-to-arginine substitutions to boost crystallization propensity and speed structure determination.TagsArginineBiological targetCrystallizationInventorsBlaine L. LoughlinJohn F. HuntNooriel E. BanayanManagerOfra WeinbergerDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2023-09-13
Assay for determining the health of CD8+ T cells1779-bAssay validates CD8+ T cell health by comparing antigen-specific proliferation to control targets, aiding autoimmunity risk assessment.TagsAntigenAssayAutoimmune diseaseInventorsHong JiangLeonard Chess MDManagerOfra WeinbergerDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2018-09-28
Treatment and Prevention of Immunological Disorders: Auto-Immune Disease, Infectious Disease, Organ Transplantation, or Tumor1779Advances targeted T cell regulation to treat autoimmunity and improve transplant, infection, and tumor therapies with fewer side effects.TagsAntigenAutoimmunityCognateInventorsHong JiangLeonard Chess MDManagerOfra WeinbergerDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2005-04-13
