Manager
Ofra Weinberger
View all technologies
Method to target T cell regulatory pathways for treatment of immunological diseases
1779-a
Targeting HLA-E restricted CD8+ T cells to induce self-tolerance, treating autoimmunity without compromising pathogen defense.
Tags
Antigen
Autoimmune disease
Cytotoxic T cell
Inventors
Hong Jiang
Leonard Chess MD
Manager
Ofra Weinberger
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-09-28
Methods to Activate or Block the HLA-E/Qa-1 Restricted CD8+ T Cell Mediated Regulatory Pathway in Treatment and Prevention of Immunological Disorders: Auto-Immune Disease, Infectious Disease, Organ Transplantation, or Tumor
1979
New Qa-1/HLA-E CD8+ T cell regulatory pathway approach enables targeted tolerance to autoimmunity, transplants, infections, and tumors.
Tags
Antigen
Autoimmunity
Cognate
Inventors
Hong Jiang
Leonard Chess MD
Manager
Ofra Weinberger
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2006-04-25
Computational methods for assessing and optimizing the protein expression potential of gene sequences in vivo
CU12083
Computationally optimize gene mRNA folding to boost in vivo protein expression, reducing costs via improved translation efficiency.
Tags
Biochemistry
Biotechnology
Data set
Inventors
Daniel Aalberts
Gregory Boel
Guy Montelione
Manager
Ofra Weinberger
Departments
Biological Sciences
Northeast Structural Genomics Consortium
Physics
Divisions
Administrative Services Bldg.
Faculty of the Arts & Sciences
Release Date
2015-03-10
Targeted Mutagenesis and Codon Selection Techniques to Improve Protein Expression and Solubility
M10-014
Codon-optimization algorithm boosts protein expression and solubility without altering sequence, enabling cost-effective industrial production.
Tags
Algorithm
Amino acid
Big data
Inventors
Gregory Boel
Guy Montelione
Helen Neely
Manager
Ofra Weinberger
Departments
Biological Sciences
Northeast Structural Genomics Consortium
Divisions
Administrative Services Bldg.
Faculty of the Arts & Sciences
Release Date
2014-07-08
Engineering surface epitopes for improving protein crystallization
M08-082
Engineers protein surfaces with epitopes via mutations to boost crystallization success for high-resolution structure determination.
Tags
Algorithm
Database
Epitope
Inventors
John F. Hunt
William Nicholson Price II
Manager
Ofra Weinberger
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2008-04-07
BulkArg: computational pipeline for improving protein crystallization propensity
CU23101
A computational pipeline suggesting lysine-to-arginine substitutions to boost crystallization propensity and speed structure determination.
Tags
Arginine
Biological target
Crystallization
Inventors
Blaine L. Loughlin
John F. Hunt
Nooriel E. Banayan
Manager
Ofra Weinberger
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2023-09-13
Assay for determining the health of CD8+ T cells
1779-b
Assay validates CD8+ T cell health by comparing antigen-specific proliferation to control targets, aiding autoimmunity risk assessment.
Tags
Antigen
Assay
Autoimmune disease
Inventors
Hong Jiang
Leonard Chess MD
Manager
Ofra Weinberger
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2018-09-28
Treatment and Prevention of Immunological Disorders: Auto-Immune Disease, Infectious Disease, Organ Transplantation, or Tumor
1779
Advances targeted T cell regulation to treat autoimmunity and improve transplant, infection, and tumor therapies with fewer side effects.
Tags
Antigen
Autoimmunity
Cognate
Inventors
Hong Jiang
Leonard Chess MD
Manager
Ofra Weinberger
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2005-04-13
