B0DETOX -- B0 Detoxification Software for Magnetic Field Shimming

Download of Manual: https://www.dropbox.com/s/4nd7qyetzexdkp7/B0DETOX_09_Manual_v28Jan2019.pdf?dl=0

To request an academic license to download and use this software, please click on "Express Licensing" above, create an account/log in if you do not have an account/are not logged in, then return to this page, and click Express Licensing again. For a commercial license, please contact techventures@columbia.edu.

This technology is a comprehensive software package for processing and analyzing B0 shimming in MRI and MRS applications.

Unmet Need: Standardized processing of B0 magnetic fields in MRI/MRS

Magnetic resonance imaging (MRI) and spectroscopy (MRS) enable non-invasive, in vivo assessment of anatomy and physiology. However, these techniques are susceptible to imperfections in the B0 magnetic field that can lead to line broadening in MRS and spatial distortions and signal dropout in MRI. Consequently, the experimental homogenization of B0 conditions, a process called B0 shimming, is a necessary component of successful MRI and MRS. While methods for B0 shimming exist, commercially-available MR systems only include basic solutions that must be extended and customized by the end user for specific applications. As such, a streamlined user-friendly B0 shimming software would greatly improve the ease of acquiring MRI and MRS data.

The Technology: User-friendly software combines processing and analysis solutions for B0 shimming

This technology combines processing and analysis solutions for experimental B0 shimming in a user-friendly interface. The workflow begins by loading experimentally-acquired B0 field maps for initial data processing. From this map, a region of interest can be accurately selected for further processing. This technology accommodates both spherical harmonic and multi-coil framework B0 shimming methods to help users achieve optimal experimental conditions. Additionally, the software loads all data sets automatically and saves data parameters for future experiments, ensuring consistent processing throughout studies. In sum, this technology provides a user-friendly software package for B0 shimming to improve data collection and quality in MRI and MRS imaging.This software has been developed, tested successfully, and is ready for use.

Applications:

• Non-invasive analysis of living cells and tissues
• Anatomical imaging
• Molecular and cellular imaging
• Drug development

Advantages:

• Simple, comprehensive user interface and workflow
• Facilitates standardized, efficient processing and analysis solutions for B0 magnetic field data
• Can use two approaches for magnetic field modeling: spherical harmonic or multi-coil framework
• Facilitates reconfigurable and storable parameter settings
• Enables experimental analysis with high reproducibility
• Can be automated

Lead Inventor:

Christoph Juchem, Ph.D.

Related Publications:

• Juchem C, Umesh Rudrapatna S, Nixon TW, de Graaf RA. “Dynamic multi-coil technique (DYNAMITE) shimming for echo-planar imaging of the human brain at 7 Tesla” NeuroImage. 2015 Jan 15;105:462–72.

• Juchem C, Herman P, Sanganahalli BG, Brown PB, McIntyre S, Nixon TW, Green D, Hyder F, de Graaf RA. “Dynamic Multi-Coil Technique (DYNAMITE) Shimming of the Rat Brain at 11.7 Tesla” NMR Biomed. 2014 Aug;27(8):897–906.

Tech Ventures Reference:

• IR CU17326

• Licensing Contact: Joan Martinez