This technology is a multi-step method for preparing biofluids for mass spectrometry analysis using common laboratory chromatography materials.
Salt and proteins are removed from biofluid samples prior to mass spectrometry analysis. Methods for removal often include solvent precipitation and/or solvent-phase extraction, but these procedures require extensive hands-on time and can be costly. To implement mass spectrometry analysis in routine clinical settings, a straightforward, efficient sample preparation method must be established.
This technology is a sample preparation method that rapidly isolates target compounds from proteins, phospholipids, and salts in biofluids. A column is loaded with three components required for isolation: an affinity matrix, a metal oxide matrix, and a sorbent, which are layered and integrated into an automated flow path. The method uses commercially available single-use chromatography materials, demonstrating its accessibility and simplicity in clinical and laboratory settings.
Mazdak Bradberry, M.D., Ph.D.
IR CU26156
Licensing Contact: Jerry Kokoshka
