Clinical application of Electromechanical Wave Imaging (EWI) to localize arrhythmias
This technology describes a methodology for applying electromechanical wave imaging (EWI) to clinical datasets obtained from FDA-approved, portable echocardiography scanners, enabling the localization of arrhythmia sources in a non-invasive manner.
Unmet Need: Non-invasive, easily accessible arrhythmia mapping
Electromechanical wave imaging (EWI) is a high-frame-rate ultrasound technique that can visualize myocardial activation in all cardiac chambers, making it possible to identify and localize arrhythmic sources non-invasively. However, due to its requirement for high-framerate echocardiography and raw radiofrequency ultrasound data as input, EWIs can only be used with the Vantage 256 Research Scanner, which has not yet received FDA approval for clinical operation. There is therefore a need for a method to apply EWI technology to existing echocardiography datasets that can be obtained using FDA-approved and widely used equipment in current clinical environments.
The Technology: Methodology to apply electromechanical wave imaging (EWI) to clinically available echocardiography scanners
This technology describes an approach that bypasses the need for high-frame-rate raw radiofrequency ultrasound input data for EWI. Instead, beamformed radiofrequency data at any depth, resolution, field of view, and frame rate captured by any portable echocardiography scanner can be imported for EWI analysis. When combined with simultaneously recorded ECG data, this methodology enables the detection of the location of the earliest and latest activated cardiac tissue, allowing for the localization of the arrhythmia source without relying on specialized high-framerate scanners.
This technology has been validated on humans and canines.
Applications:
- Diagnostic tool for the identification of arrhythmia sources
- Diagnostic tool to detect and monitor cardiac infarcts
- Research tool to detect, measure, and monitor epicardial pacing irregularities
Advantages:
- Non-invasive localization of arrhythmia sources to assist diagnosis, surgical planning, and monitoring
- Compatible with existing clinically available echocardiography scanners
- Ready-to-use
Lead Inventor:
Patent Information:
Patent Pending
Related Publications:
Tech Ventures Reference:
IR CU25148
Licensing Contact: Dovina Qu