{"id":"CU25026","slug":"collagen-barrier-for--CU25026","source":{"id":"CU25026","dataset":"techtransfer","title":"Collagen barrier for musculoskeletal tissue repair","description_":"<p>This technology is a vitrified type I collagen gel barrier that promotes healing of ligaments, tendons, menisci, and cartilage by protecting injured tissue from blood and synovial fluid while still allowing beneficial molecules to diffuse through.</p>\r\r<h2>Unmet Need: Treatment that modulate the biochemical environment after musculoskeletal injury</h2>\r\r<p>Current treatments for ligament, tendon, muscle, and cartilage injuries primarily restore mechanical function but do not adequately control the local biochemical environment that influences tissue repair. Following injury, blood and synovial fluid can expose damaged tissues to inflammatory and degradative factors that prevent repair and contribute to tissue degeneration. Currently, there are no treatments that provide a localized, selectively permeable barrier to the injury site to help modulate the local tissue healing environment.  </p>\r\r<h2>The Technology: Collagen barrier that promotes biochemical healing of musculoskeletal tissues</h2>\r\r<p>This technology is a sheet-like barrier composed of vitrified type I collagen gel that protects injured ligaments, tendons, menisci, and cartilage and promotes healing. The barrier limits negative biochemical factors found in blood and synovial fluid from entering the wound site, while still allowing critical nutrients to permeate, thereby modulating the local biochemical environment of the wound. This technology can also enable localized delivery of corticosteroids and other therapeutic agents while providing structural support to the injured tissue. </p>\r\r<h2>Applications:</h2>\r\r<ul>\r<li>Accelerated anterior cruciate ligament (ACL) repair</li>\r<li>Ligament, tendon, meniscus, and cartilage repair </li>\r<li>Ligament repair at multiple joints, such as the knee, ankle, and shoulder</li>\r<li>Localized therapeutic delivery during orthopedic surgery </li>\r<li>Research tool for studying musculoskeletal tissue regeneration</li>\r</ul>\r\r<h2>Advantages:</h2>\r\r<ul>\r<li>Creates a local healing microenvironment</li>\r<li>Limits infiltration of blood </li>\r<li>Blocks negative synovial fluid factors from entering</li>\r<li>Selectively permeable to beneficial molecules </li>\r<li>Enables sustained drug delivery to wound site</li>\r<li>Enables localized, sustained delivery of corticosteroid </li>\r<li>Can be configured as a sheet or cuff</li>\r<li>Provides structural support during tissue repair </li>\r<li>Can be cellular or acellular</li>\r</ul>\r\r<h2>Lead Inventor:</h2>\r\r<p><a href=\"https://www.thehunglab.com\">Clark T. Hung, Ph.D.</a></p>\r\r<h2>Patent Information:</h2>\r\r<p>Patent Pending(<a href=\"https://globaldossier.uspto.gov/details/US/PCTUS2611609/W/118527\">WO/2026/156269</a>)</p>\r\r<h2>Related Publications:</h2>\r\r<ul>\r<li><a href=\"https://pubmed.ncbi.nlm.nih.gov/31062877/\">Estell EG, Silverstein AM, Stefani RM, Lee AJ, Murphy LA, Shah RP, Ateshian GA, Hung CT. “Cartilage wear particles induce an inflammatory response similar to cytokines in human fibroblast‐Like Synoviocytes.” Journal of Orthopaedic Research. 2019 Sep;37(9):1979-87.</a></li>\r</ul>\r\r<h2>Tech Ventures Reference:</h2>\r\r<ul>\r<li><p>IR CU20196, CU25026</p></li>\r<li><p>Licensing Contact: <a href=\"mailto:techtransfer@columbia.edu\">Dovina Qu</a> </p></li>\r</ul>\r","tags":["Anterior cruciate ligament","Cartilage","Collagen","Corticosteroid","Cuff","Cytokine","Drug delivery","Gel","Human musculoskeletal system","Ligament","Meniscus tear","Orthopedic surgery","Skeletal muscle","Synovial fluid","Tendon"],"file_number":"CU25026","collections":[],"meta_description":"Vitrified collagen sheet shields injuries from harmful fluids while permitting nutrients and local drug delivery.","apriori_judge_output":"{\"scores\":{\"novelty\":4.0,\"potential_impact\":4.0,\"readiness\":3.0,\"scalability\":3.0,\"timeliness\":3.0},\"weighted_score\":3.55,\"risks\":[\"Prior art risk: similar barrier concepts exist in tissue engineering; patent-pending status pending validation in clinics.\",\"Regulatory pathway uncertainty for combination device/biologic with drug delivery.\",\"manufacturing feasibility at scale for collagen barrier with selective permeability.\"],\"one_sentence_take\":\"Promising novel barrier with selective permeability and local delivery potential, but needs clinical validation and clear regulatory pathway to reach high impact.\"}","inventors":["Andy J. Lee","Clark Hung","Gerard Agop Ateshian","Jack Rogot","Lance A. Murphy","Robert M. Stefani"],"manager":"Dovina Qu","depts":["Biomedical Engineering"],"divs":["Fu Foundation School of Engineering and Applied Science (SEAS)"],"date_released":"2025-11-12"},"highlight":{},"matched_queries":null,"score":0.0}