Extracellular vesicles isolation for lung and liver disease biomarkers
This technology is a method to purify lung or liver-derived extracellular vesicles as a biomarker for disease, bypassing the need for invasive biopsies directly from these tissues.
Unmet Need: Minimally invasive biopsies for lung or liver disease
Biopsies are crucial for diagnosing many diseases, but obtaining tissue samples from internal organs such as the lungs or livers is often difficult and invasive. One possible way to mitigate the invasiveness of these procedures would be to take blood samples, as most organs leave signals of their function in the bloodstream. However, the high heterogeneity of signals from different organs in blood creates substantial noise that complicates isolation and identification of tissue-specific biomarkers. As a result, there is a need for minimally invasive approaches that enable tissue-specific monitoring of disease progression and therapeutic response.
The Technology: Minimally invasive liquid biopsies for lung or liver disease
This technology provides a method to isolate and purify extracellular vesicles released by lung alveolar type 1 cells or liver hepatocytes to identify tissue-specific biomarkers in the bloodstream. Following immunoaffinity purification, extracellular vesicle cargos are analyzed for diagnostics, prognostics, or analyses of therapeutic response biomarkers. By using blood-based ‘liquid biopsy’, this approach offers a less invasive alternative to conventional lung and liver biopsies.
This technology has been validated in vitro using blood or serum samples.
Applications:
- Liquid biopsy of lung or liver
- In vitro assay for lung or liver drug screening
- Diagnostic tool for lung or liver disease
- Prognostic tool for lung or liver disease
- Research model for organ-specific signaling in the bloodstream
- Research model for extracellular vesicle signaling
Advantages:
- Minimally invasive biopsies for lung or liver
- Isolation of lung or liver signaling in bloodstream
- Provides cell-type-specificity in isolating signals
Lead Inventor:
Patent Information:
Patent Pending
Related Publications:
Tech Ventures Reference:
IR CU25187
Licensing Contact: Joan Martinez