This technology is a high-throughput single-cell multi-omics platform that integrates RNA, DNA, and protein analysis to enable comprehensive cellular profiling.
Current single-cell analysis methods often focus on isolated molecular types, such as RNA or DNA, limiting their ability to provide a holistic view of cellular processes. Existing approaches for multi-omics analysis are constrained by low throughput, restricted to extracellular proteins, or lack scalability for large-scale studies. These limitations hinder comprehensive profiling of cellular heterogeneity and the integration of genetic, transcriptional, and proteomic data critical for understanding complex biological systems. Addressing these shortcomings enables deeper insights into cellular function, disease mechanisms, and therapeutic targets.
This technology enables high-throughput analysis of RNA, DNA, and proteins from individual cells by employing microfluidic chambers to co-encapsulate cells with specialized barcoded beads. These beads independently capture nucleic acids and proteins, allowing the integration of transcriptomic, genomic, and proteomic data for comprehensive cellular profiling. The platform addresses throughput challenges by leveraging scalable barcoding techniques and avoids fixation, preserving intracellular protein data for deeper biological insights.
Patent Pending (US20220403465)
IR CU20054, CU21072
Licensing Contact: Cynthia Lang