Cancer Detection Possible with Human Retinol Dehydrogenase:
Methods of detecting compounds that are capable of inhibiting the enzymatic activity of human 9-cis retinol dehydrogenase in in-vitro and in-vivo conditions are described.
The compounds capable of inhibiting human 9-cis retinol dehydrogenase include naturally occurring and synthetic retinoids and lipids. A method for detecting a predisposition to cancer or a disease associated with either an over expression or under expression of a human 9-cis-retinol dehydrogenase is also proposed. Antisense oligonucleotides effective to prevent over expression of a human 9 cis-retinol dehydrogenase and are incorporated into pharmaceutical compositions along with a pharmaceutically acceptable carrier, are also described.
Inhibiting Enzymatic Activity in Human Retinol:
The method provides important insights into the potent inhibitors of human 9-cis retinol dehydrogenase.