{"id":"CU22060","slug":"manganese-oxide-nanoparticles--CU22060","source":{"id":"CU22060","dataset":"techtransfer","title":"Manganese oxide nanoparticles for cell-free nucleic acid scavenging","description_":"<p>This technology is an anionic manganese oxide nanoparticle that scavenges cell-free nucleic acids (cf-NAs) to reduce inflammation. </p>\r\r<h2>Unmet Need: Safe and effective scavenger of cell-free nucleic acids</h2>\r\r<p>Chronic inflammation is linked to damage-associated molecular patterns, including cell-free nucleic acids (cf-NAs), which activate innate immune responses. Dysregulated cf-NA-mediated inflammation contributes to a wide range of diseases, including rheumatoid arthritis, psoriasis, multiple sclerosis, and systemic lupus erythematosus. However, there are currently no therapies that selectively remove cf-NAs from circulation, and existing anti-inflammatory drugs do not directly target these inflammatory mediators.</p>\r\r<h2>The Technology: Low-toxicity, biodegradable anionic manganese oxide nanoparticles</h2>\r\r<p>This technology is an anionic manganese oxide nanoparticle that scavenges cell-free nucleic acids(cf-NAs). Its negatively charged surface promotes interactions with cf-NAs, particularly cell-free DNA (cfDNA), enabling the nanoparticles to act as scavengers, capturing cfDNA and inhibiting intracellular agonist-induced toll-like receptor (TLR) cell activation. The nanoparticles are biodegradable and exhibit lower toxicity than previously reported cf-NA scavengers, making them a promising therapeutic approach for inflammation-related diseases. </p>\r\r<p>This technology has been validated using TLR cell lines.</p>\r\r<h2>Applications:</h2>\r\r<ul>\r<li>Treatment of autoimmune and Inflammatory diseases</li>\r<li>Adjunctive therapy to inhibit cancer metastasis </li>\r<li>Promotion of apoptotic cells clearance</li>\r<li>Research tool for cell-free nucleic acid removal and immune signaling studies  </li>\r</ul>\r\r<h2>Advantages:</h2>\r\r<ul>\r<li>Low toxicity </li>\r<li>Biodegradable </li>\r<li>Selectively scavenges inflammatory cell-free nucleic acids  </li>\r<li>Prolonged circulation time</li>\r</ul>\r\r<h2>Lead Inventor:</h2>\r\r<p><a href=\"https://www.engineering.columbia.edu/faculty-staff/directory/kam-w-leong\">Kam W. Leong, Ph.D.</a></p>\r\r<h2>Patent Information:</h2>\r\r<p>Patent Pending(<a href=\"https://patents.google.com/patent/US20250255984A1/\">US20250255984</a>)</p>\r\r<h2>Related Publications:</h2>\r\r<ul>\r<li><a href=\"https://pubmed.ncbi.nlm.nih.gov/36382718/\">Zhong Y, Li T, Zhu Y, Zhou J, Akinade TO, Lee J, Liu F, Bhansali D, Lao Y-H, Quek CH, Shao D, Leong KW. “Targeting Proinflammatory Molecules Using Multifunctional MnO Nanoparticles to Inhibit Breast Cancer Recurrence and Metastasis” ACS Nano. 2022 Nov; 16(12): 20430-20444.</a></li>\r</ul>\r\r<h2>Tech Ventures Reference:</h2>\r\r<ul>\r<li><p>IR CU22060, CU22321</p></li>\r<li><p>Licensing Contact: <a href=\"mailto:techtransfer@columbia.edu\">Dovina Qu</a> </p></li>\r</ul>\r\r","tags":["Apoptosis","Biodegradation","Inflammation","Lupus","Metastasis","Multiple sclerosis","Nanoparticle","Nucleic acid","Psoriasis","Rheumatoid arthritis","Scavenger","Toll-like receptor"],"file_number":"CU22060","collections":[],"meta_description":"Anionic manganese oxide nanoparticles scavenge cell-free nucleic acids to reduce inflammation with low toxicity and biodegradability.","apriori_judge_output":"{\"scores\":{\"novelty\":4.0,\"potential_impact\":4.0,\"readiness\":3.0,\"scalability\":3.0,\"timeliness\":4.0},\"weighted_score\":3.9,\"risks\":[\"Potential regulatory hurdles for nanoparticle safety profile in humans\",\"Need for robust in vivo efficacy and pharmacokinetics data\",\"Scalability of nanoparticle manufacturing and batch consistency in GMP\",\"Long-term biocompatibility and clearance concerns\"],\"one_sentence_take\":\"High novelty with biodegradable MnO nanoparticles and strong potential to dampen cf-NAs, but readiness and scalability require in vivo validation and scalable manufacturing to reach strong translational impact.\"}","inventors":["Kam Leong","Yiling Zhong"],"manager":"Dovina Qu","depts":["Biomedical Engineering"],"divs":["Fu Foundation School of Engineering and Applied Science (SEAS)"],"date_released":"2026-08-14"},"highlight":{},"matched_queries":null,"score":0.0}