Monoclonal Antibody Enhancing T Cell Reactivity in AIDS Treatments
Search text
Cytokine
About 4 results
(0.14 seconds)
Unmet Need: Method for modulating immune response with ligands for natural killer T cells. A great diversity of lipids and glycolipids have been shown to bind to the various isoforms of CD1 and activate natural killer T cells. This technology describes a series of novel compounds that have been identified to act as ligands for natural killer T cells and modulate the immune response of these cells.
This method enables the generation of polyfunctional, multi-antigen-specific T cells with stimulation by one or several antigens of choice. Cellular immunotherapies utilizing cytotoxic CD4+ T cells are often impeded by the lack of a reliable method for cell manufacturing. Unmet Need: Reliable generation of potent, non-exhausted T cells.
Improved technology in this field would have numerous therapeutic applications for patients with thymic insufficiency due to advanced age, chemo/radiotherapy treatment, immunosuppressive drug treatment, graft-vs-host disease, T cell-depleted hematopoietic stem cell transplant and HIV infection. Production of T cells that are resistant to viruses such as HIV. Production of T cells with desired specificities against tumors, viral antigens, or autoantigens.
- 20T cell
- 14Immunotherapy
- 13Neoplasm
- 11Cytotoxic T cell
- 11Antigen
- 4Cytokine
- Add ...
- 4Immune system
- 4Biology
- 4Eukaryote biology
- 4Eukaryotic cells
- 4Human cells
- Add ...
- 1David Da-i Ho M.D.
- 1John Loike
- 1Megan Sykes M.D.
- 1Mithil Soni
- 1Moriya Tsuji
- Add ...
- 2Jerry Kokoshka
- 1Kristin Neuman
- 1Sara Gusik
- Add ...
- 3Medicine
- 1Columbia Center for Translational Immunology
- 1Microbiology
- 1Physicians & Surgeons
- 1Physiology
- Add ...
- 4Columbia University Medical Center (CUMC)
- Add ...
- Add ...