This technology is a customizable scaffold that recapitulates the anatomy of the periodontal ligament and directs cell behavior through templating.
Current methods of addressing periodontal ligament (PDL) regeneration have been successful in addressing partial periodontal treatment. However, they cannot be used for the regeneration of the complete periodontium. The PDL’s complex structure and strong attachment to the tooth and bone have presented a significant challenge in engineering a fully regenerative strategy for this tissue system.
This technology is a templated biomaterial scaffold that can recapitulate the highly defined anatomy of the periodontal ligament (PDL). The templating method can guide cell behavior along perforations that facilitate cell ingrowth and matrix formation. Customization of perforation dimensions can also allow for resolutions nearing those of physiological PDL. Additionally, the integration of materials such as collagen and hydroxyapatite makes this scaffold highly effective for applications within the periodontium, promoting better compatibility with both soft and mineralized tissues.
IR CU25075
Licensing Contact: Joan Martinez