{"id":"CU24189","slug":"protective-coating-method-to--CU24189","source":{"id":"CU24189","dataset":"techtransfer","title":"Protective coating method to extend bioprosthetic heart valve lifespan","description_":"<p>This technology is a pyridoxamine-based coating for transplantable heart valves that minimizes deterioration caused by calcification, oxidation, and protein deposition. </p>\r\r<h2>Unmet Need: Method to increase long-term use of bioprosthetic heart valves</h2>\r\r<p>Bioprosthetic heart valves derived from bovine or porcine tissue are widely used in valve replacement surgery but are limited by structural valve degeneration over time. This degeneration is driven by tissue calcification, oxidative damage, and the accumulation of serum proteins and advanced glycation end products, which progressively compromise valve integrity. As a result, many patients require reoperation, which carry substantial surgical risk, particularly in elderly or high-risk populations. There is a need for strategies that delays valve degenerative, extend bioprosthetic valve lifespan, and improve long-term patients’ outcomes.</p>\r\r<h2>The Technology: Pyridoxamine coating protects against bioprosthetic heart valve degradation</h2>\r\r<p>This technology is a set of pyridoxamine-based formulations for the pretreatment of bioprosthetic heart valves. The chemical addition of photoreactive benzophenone to pyridoxamine facilitates the covalent attachment of pyridoxamine to the valve. This pyridoxamine coating mitigates calcification, oxidation, and deposition of proteins on the valve leaflets. As such, these solutions can be used to prevent the structural degradation of transplanted heart valves and enhance their value as a treatment for heart valve disease.</p>\r\r<h2>Applications:</h2>\r\r<ul>\r<li>Coating of bioprosthetic heart valves</li>\r<li>Coating of other bioprosthetics</li>\r<li>Treatment for advanced glycatiation end product-associated diseases</li>\r<li>Research tool for studying diabetes-related pathologies</li>\r</ul>\r\r<h2>Advantages:</h2>\r\r<ul>\r<li>Protective against oxidative degradation</li>\r<li>Tunable chemistry</li>\r<li>Improved lifetime of bioprosthetic heart valves</li>\r<li>Cost-effective</li>\r<li>Compatible with current surgical procedures</li>\r</ul>\r\r<h2>Lead Inventor:</h2>\r\r<p><a href=\"https://columbiasurgery.org/about/giovanni-ferrari-phd\">Giovanni Ferrari, Ph.D.</a></p>\r\r<h2>Patent Information:</h2>\r\r<p>Patent Pending</p>\r\r<h2>Tech Ventures Reference:</h2>\r\r<ul>\r<li><p>IR CU24189</p></li>\r<li><p>Licensing Contact: <a href=\"mailto:techtransfer@columbia.edu\">Jerry Kokoshka</a></p></li>\r</ul>\r","tags":["Benzophenone","Bovinae","Calcification","Covalent bond","Glycation","Heart valve","Oxidative stress","Protein","Valvular heart disease"],"file_number":"CU24189","collections":[],"meta_description":"Pyridoxamine-based coating hardens bioprosthetic heart valves by reducing calcification, oxidation, and protein deposition to extend lifespan.","apriori_judge_output":"{\"scores\":{\"novelty\":4.0,\"potential_impact\":4.0,\"readiness\":3.0,\"scalability\":3.0,\"timeliness\":3.0},\"weighted_score\":3.6,\"risks\":[\"Preclinical stage with patent-pending; regulatory pathway and translation to humans unproven\",\"Manufacturing/durability of covalent coating under physiological conditions\",\"Safety and biocompatibility with long-term implantation data needed\",\"Potential market adoption depends on demonstrated reduction in reoperation rates\"],\"one_sentence_take\":\"High novelty coating strategy with multi-pathway protection shows solid impact potential, but readiness and regulatory hurdles temper near-term commercialization.\"}","inventors":["Giovanni Ferrari","Robert Levy"],"manager":"Jerry Kokoshka","depts":["Surgery"],"divs":["Columbia University Medical Center (CUMC)"],"date_released":"2026-05-29"},"highlight":{},"matched_queries":null,"score":0.0}