Real-time label-free measurement of vasopressin
This technology is a graphene nanosensor for highly sensitive and rapid responsive measurement of real-time arginine vasopressin levels.
Unmet Need: Real-time monitoring of arginine vasopressin levels
Current methods to measure arginine vasopressin (AVP) levels in blood require an enzyme-based method to react with AVP for quantification, which can be time-consuming, labor-intensive, and limited to specific time points. Accurate, real-time measurement of AVP levels may improve medical outcomes in conditions such as heart failure. There are currently no assay platforms that enable real-time label-free monitoring of AVP levels and sensitivity at lower AVP concentrations.
The Technology: Graphene nanosensor with an aptamer for highly sensitive arginine vasopressin measurement
This technology uses a graphene nanosensor with an aptamer that enables highly sensitive and rapid arginine vasopressin (AVP) measurement for real-time monitoring. Using a field-effect transistor with a long-chain AVP-specific aptamer, this sensor can measure AVP by the change in the field-effect transistor’s signals. The limit and sensitivity of AVP detection have been improved compared to similar assays by limiting background noise levels and characterizing aptameric folding upon AVP exposure.
This technology has been validated with buffered solutions.
Applications:
- Real-time arginine vasopressin (AVP) monitoring in critical care
- Diagnostic assays for conditions with high AVP levels
- Basis for biosensor devices for hypertension monitoring
- Research tool for analyzing conditions associated with high AVP levels
- Emergency medicine diagnosis of AVP-related heart failures.
Advantages:
- Real-time AVP monitoring
- Highly sensitive to low AVP levels
- Less labor-intensive compared to current analysis technology
- Quick turnaround time for results
Lead Inventor:
Patent Information:
Patent Pending
Related Publications:
Tech Ventures Reference:
IR CU22222
Licensing Contact: Dovina Qu