This technology is a graphene nanosensor for highly sensitive and rapid responsive measurement of real-time arginine vasopressin levels.
Current methods to measure arginine vasopressin (AVP) levels in blood require an enzyme-based method to react with AVP for quantification, which can be time-consuming, labor-intensive, and limited to specific time points. Accurate, real-time measurement of AVP levels may improve medical outcomes in conditions such as heart failure. There are currently no assay platforms that enable real-time label-free monitoring of AVP levels and sensitivity at lower AVP concentrations.
This technology uses a graphene nanosensor with an aptamer that enables highly sensitive and rapid arginine vasopressin (AVP) measurement for real-time monitoring. Using a field-effect transistor with a long-chain AVP-specific aptamer, this sensor can measure AVP by the change in the field-effect transistor’s signals. The limit and sensitivity of AVP detection have been improved compared to similar assays by limiting background noise levels and characterizing aptameric folding upon AVP exposure.
This technology has been validated with buffered solutions.
Patent Pending
IR CU22222
Licensing Contact: Dovina Qu
