Self-assembling DNA polymer scaffolds with material templates

This technology is a method for integrating various metallic, metal-oxide, and semiconducting materials into self-assembled DNA frameworks for advanced nanolithography.

Unmet Need: Self-assembling DNA hybrid polymers incorporating inorganic materials

Self-assembling DNA polymers can provide unique templates for functional nanomaterial incorporation and design. However, there have been challenges in incorporating inorganic materials into self-assembling DNA frameworks, which has prevented their extension into relevant applications, including advanced nanolithography. With the onset of advanced photolithography for nanoelectronics, there is a growing need to extend this technology to incorporate various metallic templating of three-dimensional DNA-based frameworks.

The Technology: Method for inorganic templating of 3D DNA frameworks

This technology is a method for integrating various metallic, metal-oxide, and semiconducting materials into self-assembled DNA frameworks. The methodology produces 3D frameworks that contain nanoscale features giving this technology the potential to greatly increase the implementation of DNA-based self-assembling materials into relevant advanced nanomanufacturing processes.

This technology has been validated by the generation of composite framework prototypes.

Applications:

• Advanced nanolithography
• Neural computing
• Nanomaterials
• Water filtration
• Drug delivery

Advantages:

• Enables functionalization of DNA scaffolds with nanoscale properties, including mechanical, electrical, and optical
• Provides method of inorganic templating for nanomanufacturing
• Templates for synthesizing artificial nanoscale structures

Lead Inventor:

Oleg Gang, Ph.D.

Patent Information:

Patent Pending

Related Publications:

• Liu H, Matthies M, Russo J, Rovigatti L, Narayanan RP, Diep T, McKeen D, Gang O, Stephanopoulos N, Sciortino F, Yan H, Romano F, Šulc P. “Inverse design of a pyrochlore lattice of DNA origami through model-driven experiments.” Science. 2024 May 17;384(6697):776-781.

• Michelson A, Subramanian A, Kisslinger K, Tiwale N, Xiang S, Shen E, Kahn JS, Nykypanchuk D, Yan H, Nam CY, Gang O. “Three-dimensional nanoscale metal, metal oxide, and semiconductor frameworks through DNA-programmable assembly and templating.” Sci Adv. 2024 Jan 12;10(2):eadl0604.

• Logan JA, Michelson A, Pattammattel A, Yan H, Gang O, Tkachenko AV. “Symmetry-specific characterization of bond orientation order in DNA-assembled nanoparticle lattices.” J Chem Phys. 2023 Oct 21;159(15):154905.

• Mao R, Minevich B, McKeen D, Chen Q, Lu F, Gang O, Mittal J. “Regulating phase behavior of nanoparticle assemblies through engineering of DNA-mediated isotropic interactions.” Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2302037120.

• Adhikari S, Minevich B, Redeker D, Michelson AN, Emamy H, Shen E, Gang O, Kumar SK. “Controlling the Self-Assembly of DNA Origami Octahedra via Manipulation of Inter-Vertex Interactions.” J Am Chem Soc. 2023 Sep 13;145(36):19578-19587.

Tech Ventures Reference:

• IR CU24073

• Licensing Contact: Greg Maskel