Single-neuron resolution recordings across the brain
This technology is a device that simultaneously records electrophysiological signals at a single-neuron resolution across the hippocampus, prefrontal cortex, premotor cortex, and amygdala.
Unmet Need: Lack of user-friendly multi-region Neuropixel deployment tools
Neuropixels are used to record high-density, simultaneous electrical activity from hundreds to thousands of neurons across multiple brain regions and layers, enabling detailed study of neural circuits and brain function. A major barrier to the widespread adoption of non-human primate Neuropixels technology is the lack of user-friendly methods for deploying it to target both deep and superficial brain areas simultaneously. Current standards are precise and accurate, but do not produce the off-the-shelf multi-targeting capacity across brain regions and/or layers.
The Technology: Device for simultaneous neuronal activity recording across the primate brain
This technology, termed the Neuropixels Rail Drive System (NRDS), is designed to enable in vivo electrophysiological experiments in the non-human primate brain across multiple regions. It enables the simultaneous recording of single-neuron activity in both superficial and deep brain regions.
The technology has been validated in vivo in non-human primates.
Applications:
- Neuroscience research model for studying systems-level behavior and function, neural injury, and reconstruction
- Diagnostic for multi-region neurological disorders
- Monitoring tool for longitudinal studies on chronic neurological conditions
- Brain-computer interface development
- Neurostimulation systems
Advantages:
- Maximizes the number of Neuropixels per recording chamber
- Extreme control and precision in targeting particular brain regions and/or layers
- Integrates with other neuroscience software systems
- Compatible with any type of recording chamber design
Lead Inventor:
Patent Information:
Patent Pending
Tech Ventures Reference:
IR CU25180
Licensing Contact: Kristin Neuman