This technology is a fabrication method for gelatin-based extracellular matrix analogs for use in cell culture studies of tissue regeneration and repair.
Physiologically accurate models of the extracellular matrix (ECM) are essential to studying the biology of tissue repair and healing. Replicating both the 3D structure and bioactive properties of the ECM in vitro is challenging. Current approaches lack the bioactive domains inherent in the collagenous ECM and may involve the use of toxic components, which limits their applicability in vivo and hampers their use as a research platform.
This technology describes a fabrication method for an improved ECM analog by combining the advantages of gelatin mesh and hydrogel-based ECM analogs. In doing so, the technique avoids the toxicity of chemical crosslinking and demonstrates less variation between batches. This technology can advance the study of tissue regeneration and repair by providing a more consistent and biomimetic ECM analog for in vitro cell culture studies.
IR CU20121
Licensing Contact: Joan Martinez