{"id":"CU23091","slug":"synchronized-multichannel-led--CU23091","source":{"id":"CU23091","dataset":"techtransfer","title":"Synchronized multichannel LED controller for imaging and optogenetics","description_":"<p>This technology is an open-source multichannel LED controller that precisely regulates the intensity and timing of high-power light sources and synchronizes with microscope scanning to enable artifact-free visual simulation and optogenetic activation during imaging.</p>\r\r<h2>Unmet Need: Lack of synchronized LED control with microscopy imaging systems</h2>\r\r<p>Separation of fluorescence signals from optical stimulation during two-photon imaging is critical for capturing high-fidelity, low-noise neural data. Current approaches for presenting visual stimulation rely on optical filters, manual screening, or both, and offer only partial solutions, with residual artifacts appearing in the recorded movies. These methods lack precise synchronization between light stimulation and imaging acquisition, leading to interference between excitation, illumination, and detection. Addressing this gap is essential for enabling artifact-free integration of stimulation and high-resolution imaging.</p>\r\r<h2>The Technology: Synchronized LED control system for artifact-free functional imaging</h2>\r\r<p>This technology is a multichannel LED controller that enables precise, synchronized control of high-power light sources for visual stimulation and optogenetic activation. This system can precisely control up to eight LED outputs at currents up to 1.8 A with milliamp-level precision and minimal power ripple across the full operating range. Using a microsecond-accurate timing scheme, the system enables precise modulation via external analog signals and coordination with imaging workflows. This enables reliable integration of optical stimulation with high-resolution imaging.</p>\r\r<p>This technology has been validated <i> in vivo </i> for optical stimulation and optogenetic applications in Drosophila and mouse models.</p>\r\r<h2>Applications:</h2>\r\r<ul>\r<li>Research instrumentation for optogenetic functional imaging</li>\r<li>Video game graphics control </li>\r<li>Commercial hardware for diagnostic imaging systems</li>\r<li>Spectrally controlled illumination for lighting and sensing applications</li>\r<li>Safety and monitoring system for LED output</li>\r</ul>\r\r<h2>Advantages:</h2>\r\r<ul>\r<li>Eliminated artifacts in the recorded movies </li>\r<li>Simplified and automated flyback synchronization and LED control </li>\r<li>Compensated for LED rise and decay times</li>\r</ul>\r\r<h2>Lead Inventor:</h2>\r\r<p><a href=\"https://zuckermaninstitute.columbia.edu/rudy-behnia-phd\">Rudy Behnia, Ph.D.</a></p>\r\r<h2>Patent Information:</h2>\r\r<p>Patent Pending (US <a href=\"https://patents.google.com/patent/US20240142757A1/en?oq=18%2f384%2c201\">20240142757</a>)</p>\r\r<h2>Related Publications:</h2>\r\r<ul>\r<li><a href=\"https://www.nature.com/articles/s41593-024-01640-4\">Christenson MP, Sanz Diez A, Heath SL, Saavedra-Weisenhaus M, Adachi A, Nern A, Abbott LF, Behnia R. “Hue selectivity from recurrent circuitry in Drosophila.” Nature Neuroscience. 2024 May 16; 27(6): 1137–1147.</a></li>\r</ul>\r\r<h2>Tech Ventures Reference:</h2>\r\r<ul>\r<li><p>IR CU23091</p></li>\r<li><p>Licensing Contact: <a href=\"mailto:techtransfer@columbia.edu\">Kristin Neuman</a> </p></li>\r</ul>","tags":["Augmented reality","Drosophila melanogaster","Functional magnetic resonance imaging","High-throughput screening","Medical imaging","Modulation","Optogenetics","Synchronization","Two-photon excitation microscopy"],"file_number":"CU23091","collections":[],"meta_description":"Open-source, eight-channel LED controller with microsecond synchronization to microscopy, enabling artifact-free optogenetics during imaging.","apriori_judge_output":"{\"scores\":{\"novelty\":4.0,\"potential_impact\":4.0,\"readiness\":4.0,\"scalability\":3.0,\"timeliness\":4.0},\"weighted_score\":3.95,\"risks\":[\"Open-source hardware may face manufacturing and IP clearance challenges for commercialization.\",\"Dependency on precise synchronization hardware could limit off-the-shelf scalability.\",\"Regulatory considerations for diagnostic/clinical deployment not addressed.\"],\"one_sentence_take\":\"Strong novelty and readiness with practical impact, but scalability and manufacturing/IP hurdles temper the overall commercial potential.\"}","inventors":["Darcy Peterka","Richard Horrigo","Rudy Behnia","Seyed Navid Mousavi","Tanya Tabachnik"],"manager":"Kristin Neuman","depts":["Mortimer B. Zuckerman Mind Brain Behavior Institute","Neuroscience"],"divs":["Columbia University Medical Center (CUMC)","Zuckerman Mind Brain Behavior Inst"],"date_released":"2026-04-24"},"highlight":{},"matched_queries":null,"score":0.0}