Oncology - Columbia Technology Ventures

Engineered model of human bone marrow for diagnosis and prediction of cancer metastasis

CU23273

Apr 8, 2024 · This technology is patient-specific engineered model of bone marrow for diagnostics and research of cancer progression using a sample of patient’s serum.

Inventors: Daniel Naveed Tavakol, Gordana Vunjak-Novakovic, Pamela Graney

12Assay Bone marrow Cancer staging

Fu Foundation School of Engineering and Applied Science (SEAS)

Biomedical Engineering

Bioengineered human bone marrow model for drug discovery

CU22388

Feb 27, 2024 · This technology is a bioengineered bone marrow system that can be applied to study various human diseases, toxicity responses, and immune functions in vitro.

Inventors: Adolfo A. Ferrando M.D., Ph.D., Daniel Naveed Tavakol, Gordana Vunjak-Novakovic, Jessie Brown

18Anemia Biomaterial Bone marrow

Biomedical Engineering Institute for Cancer Genetics Pediatrics

Columbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)

Antibody therapeutic targeting Funsobacterium nucleatum-mediated diseases

CU21261

Feb 9, 2024 · This technology is a monoclonal antibody which binds annexin for the inhibition of Funsobacterium nucleatum (Fn) invasion and proliferation to treat and prevent Fn related diseases including colorectal cancer and Familial Adenomatous Polyposis (FAP).

Inventors: Yiping Han

14Antibiotic Antibody Bacteria

Jerry Kokoshka

Periodontics

Columbia University Medical Campus (CUMC)

Optical catheters and methods for diagnosis of uterine cancer and fibroids

CU23142

Jan 18, 2024 · This technology is an optical catheter method for the analysis of uterine tissue using spectrometry without removing a sample from the patient.

Inventors: Aidan Therien, Arielle Joasil, Christine P. Hendon, Haiqiu Yang

7Carcinoma Catheter Curettage

Dovina Qu

Electrical Engineering

Fu Foundation School of Engineering and Applied Science (SEAS)

3D organoids for modeling squamous epithelial pathology and personalized medicine

CU22301

Jan 4, 2024 · This technology is a method to generate squamous epithelial 3D organoids that can mimic the natural physiology of tissues and be used to model gastrointestinal physiology.

Inventors: Anil K. Rustgi M.D., Hiroshi Nakagawa

10Adenocarcinoma Carcinoma Epithelium

Herbert Irving Comprehensive Cancer Center Medicine

Patient-specific organoid system for pancreatic ductal adenocarcinoma (PDAC) drug screening

CU24025

Nov 30, 2023 · This technology is an in vitro platform for studying pancreatic cancer in a patient-specific manner for personalized medicine approaches.

Inventors: Gulam Manji, Ilenia Pellicciotta

9Cell therapy High-throughput screening Immune system

Medicine

Peptide nucleic acid conjugates for altering gene expression in cancer

CU16241

Nov 3, 2023 · This technology is a nucleic acid-based polymer system that can be engineered to target the expression of specific cancer-associated genes for therapeutic benefit.

Inventors: Gary Schwartz M.D., Jeffrey Rothman M.D.

16Bioavailability Biosensor Cell culture

Medicine Oncology

Modular, multi-tissue system for in vitro modeling of systemic disease

CU19102

Oct 31, 2023 · This technology is a modular platform with engineered tissues linked by vascular perfusion that can be used to study tumor progression and systemic disease in a clinically relevant setting.

Inventors: Alan Chramiec, Andrea Califano Ph.D., Ece Ozturk, Gordana Vunjak-Novakovic, Kacey Ronaldson, Peter A. Sims

11Bone marrow Circulatory system Crosstalk

Biochemistry & Molecular Biophysics Biomedical Engineering Biomedical Informatics

Columbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)

Truncated ATF5, CEBPB, and CEBPD inhibitors for effective cancer treatment

CU21274

Oct 31, 2023 · This technology is a shortened version of cell-penetrating, dominant-negative peptides of ATF5, CEBPB, CEBPD for cancer treatment.

Inventors: James M. Angelastro, Lloyd Greene PhD, Qing Zhou

16Breast cancer Cancer Cancer cell

Jerry Kokoshka

Molecular Biosciences Pathology Pathology & Cell Biology

ssg-MeDIP-Seq and sscf-MeDIP-Seq for DNA methylation detection

CU24002

Sep 25, 2023 · This technology is two methods, called ssg-MeDIP-Seq and sscf-MeDIP-Seq, for improved tumor detection using detection of DNA methylation density in genomic DNA, and of hemi-methylated regions in plasma cell-free DNA.

Inventors: Hui Zhou, Xu Hua, Zhiguo Zhang Ph.D.

8Artificial intelligence Biomarker Blood plasma

Genetics & Development Institute for Cancer Genetics

Retinoid signaling inverse agonist as a treatment for adenoid cystic carcinoma

CU20036

Sep 20, 2023 · This technology is a targeted anti-tumor agent designed to treat adenoid cystic carcinoma (ACC) by utilizing retinoid receptor modulation to promote cancer cell differentiation and selective cell death.

Inventors: Piero D. Dalerba, Sara Viragova

11Adenoid Adjuvant therapy Carcinogenesis

Sara Gusik

Pathology & Cell Biology

T cell co-receptor clustering for cancer treatment

CU22398

Sep 5, 2023 · This technology is a SLAMF6 bispecific antibody to enhance T-cell activation through compartmentalization that can be used for tumor treatments.

Inventors: Adam Mor

5Cancer immunotherapy Co-receptor Immunotherapy

Rheumatology

Tagmentation-based method to improve global DNA methylation assays

CU23112

Aug 15, 2023 · efficiency and convenience of studying methylation patterns in normal and disease conditions including early cancer detection.

Inventors: Hui Zhou, Hui-Chen Wu, Regina Santella Ph.D., Zhiguo Zhang Ph.D.

7DNA ligase DNA methylation Gene expression

Environmental Health Science Genetics & Development Institute for Cancer Genetics

Columbia University Medical Center (CUMC)Mailman School Of Public Health (MSPH)

Non-invasive method for detection of cancer methylomes

CU21185

Aug 4, 2023 · This technology is a method of isolating polynucleotides from cell-free non-invasive bodily samples and sequencing them to detect methylated DNA to identify early tumors.

Inventors: Hui Zhou, Regina Santella Ph.D., Zhiguo Zhang

195-Methylcytosine Antibody Assay