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Platform/Research Tool - Columbia Technology Ventures

Platform/Research Tool

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Two-photon holographic microscope system for 3D neuronal circuit imaging and stimulation
This technology is a fully integrated holographic microscope system capable of simultaneous, high-resolution imaging and precise stimulation of 3D neuronal circuits using optogenetics.
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Adaptive opticsHolographyMicroscopy
Rafael YusteYuriy Shymkiv
Kristin Neuman
Biological Sciences
Faculty of the Arts & Sciences
2023-12-04
Disease-in-a-dish model of neuropsychiatric diseases for high-throughput therapeutic screening
This technology is an in vitro platform for assessing the role of epigenetic changes in neuropsychiatric diseases.
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Amyotrophic lateral sclerosisAutismEnzyme
Bin XuJoseph A. Gogos
Joan Martinez
Physiology and Cellular BiophysicsPsychiatry
Columbia University Medical Center (CUMC)
2020-10-02
Method for studying in-cell single-molecule FRET data collected from proteins diffusing at membrane surfaces using wide-field imaging
This technology is an approach to simultaneously track donor-acceptor-tagged proteins or pairs of proteins and observe their FRET signal during diffusion at the plasma membrane, thereby linking protein structural dynamics and protein-protein interactions to their movement at the cell membrane.
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BiophysicsCell membraneConfocal microscopy
Jonathan JavitchKhuloud JaqamanPeter Geggier
Jerry Kokoshka
BiophysicsPsychiatry
Columbia University Medical Center (CUMC)
2025-03-05
Engineered model of human bone marrow for diagnosis and prediction of cancer metastasis
This technology is patient-specific engineered model of bone marrow for diagnostics and research of cancer progression using a sample of patient’s serum.
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AssayAutoimmune diseaseBone marrow
Daniel Naveed TavakolGordana Vunjak-NovakovicPamela Graney
Cynthia Lang
Biomedical Engineering
Fu Foundation School of Engineering and Applied Science (SEAS)
2024-04-08
A peptide microarray for serodiagnosis of exposure to high-threat hemorrhagic fever viruses
This technology is a programmable peptide microarray platform capable of identifying immunoreactive epitopes for high-specificity serodiagnosis of hemorrhagic fever viruses, including Ebola virus.
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AntibodyBlood plasmaBlood transfusion
4
Lisa HensleyNischay MishraSunil Kumar Dubey
Kristin Neuman
Center for Infection and ImmunityEpidemiology
Mailman School Of Public Health (MSPH)
2024-01-10
Swept, Confocally-Aligned, Planar Excitation (SCAPE) Microscopy Using a Graded-Index (GRIN) lens for deep tissue imaging
This technology, GRIN-SCAPE, is a high-speed microscopy approach for imaging deep 3D tissue dynamics in awake, freely behaving animals that combines Swept, Confocally-Aligned Planar Excitation (SCAPE) microscopy with a Graded-Index (GRIN) lens.
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Anatomical terms of locationBrainBrainstem
Elizabeth HillmanGrace Sooyeon LeeWenxuan Liang
Kristin Neuman
Biomedical EngineeringMortimer B. Zuckerman Mind Brain Behavior Institute
Fu Foundation School of Engineering and Applied Science (SEAS)
2023-09-25
Framework for storage and management of large-scale neural data
This technology is a framework for efficiently storing, sending, processing, and receiving real-time data from commercial neurotech devices and wearables.
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Cloud storageCross-platform softwareData processing
Baihan Lin
Greg Maskel
Systems Biology
2023-08-17
Efficient drug discovery pipeline and lead compounds for Alzheimer's disease
This technology is a comprehensive compound design and preclinical testing platform that can be used to develop multifunctional drugs for Alzheimer’s disease, and has already led to the development of several promising lead compounds.
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AgonistAmyloid betaAnimal testing
Caghan Kizil
Joan Martinez
Neurology
Columbia University Medical Center (CUMC)
2023-05-10
Speech analysis software for diagnosis of dementias
This technology is an automated screening algorithm that analyzes patterns in verbal communication for early stage diagnosis of Alzheimer’s disease and related cognitive impairments.
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AcousticsArtificial intelligenceAssay
Maryam Zolnoori
Kristin Neuman
School of Nursing
School of Nursing (CUMC)
2023-03-08
DSSR: an integrated software tool for dissecting the spatial structure of RNA
Thanks to the NIH R24GM153869 grant, we are pleased to provide DSSR Basic free of charge to the academic community.
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AcidBioinformaticsIn silico
Harmen J. BussemakerXiang-Jun Lu
Dovina Qu
Biological Sciences
Faculty of the Arts & Sciences
2020-06-15
Modular, multi-tissue system for in vitro modeling of systemic disease
This technology is a modular platform with engineered tissues linked by vascular perfusion that can be used to study tumor progression and systemic disease in a clinically relevant setting.
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Circulatory systemCrosstalkEndothelium
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Alan ChramiecAndrea Califano Ph.D.Ece Ozturk
Cynthia Lang
Biochemistry & Molecular BiophysicsBiomedical EngineeringBiomedical Informatics
Columbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)
2023-10-31
Platform for the assembly of 3D hierarchically-organized nanomaterials
This technology is a platform to organize nanoscale objects into a 3D array using DNA programmable interactions, that can be used to generate 3D hierarchically ordered materials for optical and energy applications.
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EnergyLithographyMesoscopic physics
4
Aaron MichelsonBrian MinevichJason S. Kahn
Greg Maskel
Applied Physics & Applied Math (APAM)Chemical Engineering/Applied Chemistry
Fu Foundation School of Engineering and Applied Science (SEAS)
2023-05-02
Blockchain platform for the storage of clinical and genetic data
This technology is a blockchain solution for the harmonized integration of clinical and biological data used in personalized medicine.
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Amyotrophic lateral sclerosisBlockchainClinical trial
Ahmed ElhusseinGamze Gursoy
Joan Martinez
Biomedical Informatics
Columbia University Medical Center (CUMC)
2023-02-28
Modular human body-on-a-chip platform
This technology is a customizable platform for growing micro-organ cultures to study multimodal physiological responses and potentially facilitate more efficient, cost-effective drug development.
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BiocompatibilityBiomaterialBiomimetics
Gordana Vunjak-NovakovicKacey RonaldsonKeith Yeager
Cynthia Lang
Biomedical Engineering
Fu Foundation School of Engineering and Applied Science (SEAS)
2020-03-05
Cell-type specific covalent modifications of proteins in vivo
This technology is an in vivo system in which a covalent bond can be formed between any two proteins in a cell-type specific manner for the purpose of immunoprecipitation, visualization, or modifying the activity of a target protein.
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AntibodyAntigenAssay
Richard S. MannSiqian Feng
Jerry Kokoshka
Biochemistry & Molecular BiophysicsBiochemistry & Molecular Biophysics, Zuckerman Institute
Columbia University Medical Center (CUMC)
2022-06-19