Thanks to the NIH R24GM153869 grant, we are pleased to provide DSSR Basic free of charge to the academic community. Academic Users may submit a license request for DSSR Basic or DSSR Pro by clicking "Express Licensing". Commercial users may inquire about pricing and licensing terms by emailing techtransfer@columbia.edu, copying xiangjun@x3dna.org
DSSR Pro excels in structural bioinformatics of RNA, DNA, and their protein complexes. The software has completely superseded 3DNA, and is being continuously improved. Revenue from licensing supports the development and availability of DSSR.This technology is a software tool for analyzing, annotating, and modeling the 3D tertiary structure of nucleic acids. DSSR Pro has more functionality than DSSR Basic, including: (i) homology modeling via in silico base mutations, (ii) easy generation of regular helical models, and (iii) creation of customized structures with user-specific base sequences and rigid-body parameters. DSSR Pro supersedes 3DNA completely while DSSR basic has no modeling capabilities and less analysis/annotation features. DSSR Pro integrates disparate analysis and modeling programs of 3DNA under one umbrella, and offers much more via an easier to use interface.DSSR Pro includes an in-depth user manual, and one year technical support directly from the developer. DSSR basic is provided AS IS, and does not include any support.
Understanding the three-dimensional architecture of nucleic acids, such as RNA, is essential for understanding their cellular functions. However, current bioinformatics tools can be tedious to use and often require multiple programs to capture relevant features such as paired bases, A-form double helices, loops, and pseudoknots. They also may overlook certain features, or do not provide functionality for key research questions, such as nucleotide modifications.
This technology is a software named DSSR (Dissecting the Spatial Structure of RNA) that integrates and streamlines the detection and analysis of nucleic acid structure, combining and expanding upon the functionality of existing, disparate bioinformatics tools. This software can automatically detect and characterize an expansive list of relevant nucleic acid structural features. Furthermore, it can process data from a variety of sources and handles both RNA and DNA as well as RNA/DNA-protein complexes. DSSR has integrated functionality with Jmol and PyMOL, enabling flexible and innovative search functionality and visualization of structures and analysis. This software is also able to flexibly model in silico base mutations.
