Dynein inhibition for enhanced anti-tumor cytotoxicity in solid tumorsCU24341Dynein inhibition boosts natural killer cell cytotoxicity against solid tumors, enhancing immunotherapy efficacy across diverse microenvironments.TagsAdjuvantCytotoxic T cellDyneinInventorsJordan S. Orange MD, PhDManagerJerry KokoshkaDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
Drug-resistant pancreatic cancer cell lines for drug testingCU25070Pan-RAS-GTP resistant PDAC cell lines enable in vitro drug testing and resistance mechanism study on RAS inhibitors.TagsChemotherapyDrug discoveryDrug resistanceInventorsKenneth P. Olive Ph.D.ManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterDivisionsColumbia University Medical Center (CUMC)Release Date2024-12-06
PAMAM nanoparticle for chemotherapy delivery to reduce metastasis and cognitive impairmentCU22225PAMAM nanoparticles deliver chemotherapy while scavenging cell-free nucleic acids to reduce metastasis and cognitive impairment.TagsBreast cancerChemotherapyCognitive deficitInventorsDivya BhansaliHongxia WangKam LeongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-04-24
3D organoids for modeling squamous epithelial pathology and personalized medicineCU223013D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.TagsAdenocarcinomaCarcinomaEpitheliumInventorsAnil K. Rustgi M.D.Hiroshi NakagawaManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-04CollectionsOncology
Computational method for brain tumor classification and improved prognosisCU21156Integrates multi-omics to subtype glioblastoma, revealing four functional states and subtype-specific treatment targets.TagsBreast cancerGlioblastomaGliomaInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-01CollectionsOncology
Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseasesCU23208AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.TagsAmyotrophic lateral sclerosisGene expressionGene therapyInventorsEmily Rhodes LowryHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-18CollectionsGene Therapy
Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapyCU24385Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.TagsAntigenCell cultureCell therapyInventorsMithil SoniPawel MuranskiPrabesh KhatiwadaManagerJerry KokoshkaDepartmentsColumbia Center for Translational ImmunologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Targeted knock-in mouse line for studying neuropsychiatric diseaseCU26034A knock-in mouse line enabling precise A2a-expressing neuron targeting in basal ganglia for neuropsychiatric research and drug validation.TagsAdenosine A2A receptorBasal gangliaCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Treatment and prevention of intestinal graft-versus-host disease following HPSC transplantationCU23034GLP-2 analogs strengthen intestinal barrier to prevent/treat GVHD after allogeneic stem cell transplantation.TagsAllotransplantationChemotherapyGraft-versus-host diseaseInventorsDavid HarleRan ReshefManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-04-21
Human ALFY knock-in mice for studying neurodegenerative diseaseCU26143Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.TagsAutophagyCopy number variationCre recombinaseInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Conditional depletion of WDFY3 in murine models of diseaseCU26144Engineered mouse with conditional WDFY3 knockout to study autophagy, mitophagy, efferocytosis, and neurodegenerative disease mechanisms.TagsAmino acidAutism spectrumAutophagyInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Autophagy activating nucleotide sequence for neurodegenerative disease treatmentCU23286Nucleotide sequence boosts ALFY (WDFY3) to enhance autophagic clearance of neurodegenerative protein aggregates.TagsAutophagyDrug discoveryGeneInventorsAi YamamotoKatherine R. CroceManagerKristin NeumanDepartmentsPathology & Cell BiologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-12-20CollectionsCNS/Neurology
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's diseaseCU26032Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.TagsBiomarkerCausalityCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Engineered bacterial platform for localized cancer therapyCU26042Engineered bacteria deliver localized chemoimmunotherapy to tumors, combining prodrug activation, IL-15 boosting, and PD-L1 blockade.TagsBacteriaBiopharmaceuticalChemotherapyInventorsJongwon ImNicholas ArpaiaTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-05-15
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsAngiogenesisBiomarkerBone marrowInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
PEG-SSRI conjugate for localized treatment of inflammatory bowel diseaseCU25441PEG-FLX conjugate enables oral, localized anti-IBD therapy with prolonged intestinal retention and reduced systemic exposure.TagsAnti-inflammatoryBioavailabilityDiseaseInventorsChuanxu ChengHanyao HuangKam LeongManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-04-21
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous systemCU22281Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.TagsCentral nervous systemCholinergicGene expressionInventorsHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsGene TherapyCNS/Neurology
Ethyl pyruvate for the treatment of glaucoma and intraocular diseaseCU22343Ethyl pyruvate stabilizes cellular energy, boosts antioxidant defenses, and provides neuroprotection for glaucoma and IOP-related diseases.TagsAnti-aging movementAntioxidantCell membraneInventorsNicholas TolmanSimon JohnManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-09-19CollectionsOphthalmology
Tissue-selective GABA(A) receptor modulators for asthma and bronchoconstrictive airway diseaseCU24261Airway-targeted GABA(A) modulators relax smooth muscle and reduce inflammation without CNS sedation, offering non-sedating asthma therapy.TagsAgonistAnticholinergicAsthmaInventorsCharles W. Emala M.D.ManagerSara GusikDepartmentsAnesthesiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-08-03
Targeting ID2 to impair hypoxic cancer stem cell proliferationCU16166Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.TagsAngiogenesisCancer stem cellCell proliferationInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsOncology
Human-informed artificial intelligence system for enhanced eye disease detectionCU23260Expert-eye-movement informed AI enhances glaucoma, AMD detection with interpretable, trainee-friendly, weakly supervised vision transformers.TagsArtificial intelligenceConvolutional neural networkDeep learningInventorsGeorge CioffiKaveri ThakoorManagerDovina QuDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-21CollectionsArtificial Intelligence (AI)
In vivo internalizing RGD peptide production for enhanced treatment of solid tumorsCU25033In vivo iRGD plasmid drives tumor penetration, reducing immunosuppression; co-administers with CAR-T/ therapies for enhanced efficacy.TagsAngiogenesisCancer immunotherapyChemotherapyInventorsKazuki N. SugaharaNorio MiyamuraManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
Preventive therapeutic of stress-induced psychiatric disordersCU21050Prophylactic VPAC2 agonist treatment prevents stress-induced fear, anxiety, and depression-like behaviors, boosting resilience in mice.TagsPost-traumatic stress disorderPreventive healthcarePsychiatryInventorsBriana Kaying ChenChristine Ann DennyManagerCynthia LangDepartmentsCENTER OF NEUROBIOLOGY AND BEHAVIORPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-05
Small Molecule Inhibitors of Pathological Stress Granule FormationCU26002Small molecules block TIA1-driven stress granule formation, reducing pathological protein aggregation in neurodegenerative diseases.TagsAssayChemotherapyCytotoxicityInventorsDonald William Landry MD, Ph.D.Joseph B. Rayman Ph.D.Shi-xian DengManagerJerry KokoshkaDepartmentsMedicineNeuroscienceDivisionsColumbia University Medical Center (CUMC)Release Date2026-08-03
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsActive siteAllosteric regulationApoptosisInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Nanoparticle system for targeted cancer treatmentCU21031Targeted scavenging nanoparticles deliver non-opioid cancer therapy and pain relief, reducing inflammation and metastasis.TagsCancerChemotherapyDrug resistanceInventorsDivya BhansaliKam LeongTianyu LiManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-05-01CollectionsOncology
CRISPR-IMPRINT for rapid and selective DNA methylationCU26076CRISPR-IMPRINT enables rapid, selective DNA methylation editing with low off-targets and cytotoxicity for research and therapy.TagsAlleleCell therapyCytosineInventorsShawn (X.) Liu Ph.D.ManagerJoan MartinezDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-08-10
Machine learning tool for diagnosis of cutaneous T-cell lymphoma (CTCL)CU24366AI-powered CTCL diagnosis tool links genetic markers with EHR data to improve accuracy, staging, and prognosis.TagsAssayCancerCutaneous T cell lymphomaInventorsLarisa GeskinManagerCynthia LangDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30CollectionsArtificial Intelligence (AI)
Cysview and blue light irradiation for effective and non-invasive bladder cancer therapyCU24375Cysview-based blue-light therapy non-invasively kills bladder cancer cells via rapid ROS, enabling broad, targeted treatment.TagsBladder cancerCancerChemotherapyInventorsJustin MatulayMichael Shen Ph.D.Talal Ahsan SyedManagerJoan MartinezDepartmentsBiological SciencesMedicineUrologyDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2025-01-02
Efficient drug discovery pipeline and lead compounds for Alzheimer's diseaseCU23156Multi-target Alzheimer’s drug discovery platform accelerates preclinical lead compounds with in vitro/in vivo efficacy and safety.TagsAgonistAmyloid betaAnimal testingInventorsCaghan KizilManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsSmall MoleculeCNS/NeurologyPlatform/Research Tool
Modular, multi-tissue system for in vitro modeling of systemic diseaseCU19102Multi-tissue organ-on-a-chip platform enables vascular-coupled, patient-specific modeling of systemic disease and cancer metastasis.TagsCirculatory systemCrosstalkEndotheliumInventorsAlan ChramiecAndrea Califano Ph.D.Ece OzturkManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-10-31CollectionsOncologyPlatform/Research Tool
Sensitive, non-invasive diagnostic assay for detecting prostate cancerCU22152Noninvasive urine RAD9 methylation test detects aggressive prostate cancer, boosting accuracy and enabling point-of-care prognosis.TagsAssayBladder cancerBlood testInventorsCatherine Spina MD, PhDHoward Brett Lieberman Ph.D.Kevin HopkinsManagerKristin NeumanDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-23
Programmable bacteria for targeted delivery of cancer therapeuticsCU18339Engineered tumor-targeting bacteria deliver immunotherapies locally, boosting efficacy and reducing systemic toxicity in cancer treatment.TagsAntigenCancer immunotherapyChemotherapyInventorsCandice GurbatriNicholas ArpaiaSreyan ChowdhuryManagerCynthia LangDepartmentsBiomedical EngineeringMicrobiologyDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-04-07
Injectable hydrogels for therapeutic deliveryCU25086Injectable, biocompatible hydrogel using extracellular vesicles as dynamic crosslinkers for tunable tissue regeneration and delivery.TagsAngiogenesisBiocompatibilityBiomaterialInventorsArtemis MargaronisCaterina PiuntiCindy Huilin LuManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-15
Therapeutic strategy for treating glioblastoma by targeting the LINC complexCU26167Targeting the LINC complex, specifically nesprin-2, with RNAi/gene therapies to curb glioblastoma growth and therapy resistance.TagsCell migrationCell nucleusCell proliferationInventorsGregg G. GundersenOsama Al DalahmahSusumu AntokuManagerJerry KokoshkaDepartmentsPathologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-08-11
Antisense oligonucleotides for MYC-targeted cancer therapyCU25384Steric-blocking ASOs target MYC 3’UTR to suppress MYC activity, inhibiting cancer growth without degrading mRNA or protein.TagsCancer cellCis-regulatory elementDrug deliveryInventorsPeiguo ShiXuebing WuManagerJoan MartinezDepartmentsMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2026-06-18
Tumor-selective targeting of immunosuppressive Tregs for cancer treatmentCU23280Tumor-selective depletion of immunosuppressive Tregs via αvβ5 marker and iRGD peptide to boost PDAC immunotherapy.TagsCancer immunotherapyCytotoxicityImmunosuppressionInventorsKazuki N. SugaharaKodai SuzukiNorio MiyamuraManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2026-04-17
Cross-platform radiomics toolkit for predictive cancer imagingProxy116Cross-platform radiomics toolkit automates standardized 2D/3D cancer imaging analysis for reproducible, scalable biomarker discovery.TagsBatch processingCross-platform softwareFeature extractionInventorsChristos DavatzikosDespina KontosManagerJoan MartinezDepartmentsRadiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-12-04
RNA and ATAC mutual sequencing (RAM-seq) for simultaneous single-cell transcriptome and chromatin profilingCU21355RAM-seq enables simultaneous single-cell RNA and chromatin profiling without microfluidics, using plate-based dual-omics sequencing.TagsChemical libraryChromatinMicrofluidicsInventorsAbbas Rizvi Ph.D.Elena KandrorThomas P. Maniatis Ph.D.ManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsMortimer B. Zuckerman Mind Brain Behavior InstituteDivisionsColumbia University Medical Center (CUMC)Release Date2026-08-27
Combined small molecule treatment as a synergistic epigenetic therapy for pancreatic cancerCU23218Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.TagsAdenocarcinomaApoptosisChemotherapyInventorsAntonio FojoMaryam SafariSusan BatesManagerJerry KokoshkaDepartmentsMedicineOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-08-22
Engineered probiotics for safe and targeted cancer vaccinesCU25192Engineered bacteria deliver tumor neoantigens to solid tumors, boosting targeted, durable immunotherapy with minimal dosing.TagsAntigenBacteriaCancer immunotherapyInventorsJongwon ImTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-03-27
Targeting Delta-2 tubulin for the treatment of peripheral neuropathyCU25119Delta-2 tubulin as a biomarker and therapeutic target to treat and predict chemotherapy-induced peripheral neuropathy.TagsAnalgesicAnticonvulsantAntidepressantInventorsFrancesca Bartolini Ph.D.Maria Elena PeroManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17CollectionsCNS/Neurology
Tumor-penetrating peptide for enhancing immunotherapy in solid tumorsCU26104Tumor-penetrating peptide remodels desmoplastic tumors to boost immunotherapy, enabling T-cell infiltration with targeted, local TME modulation.TagsCancer cellCytotoxic T cellImmunosuppressionInventorsAndrew M. LowyKazuki N. SugaharaManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2026-07-06
Palmitoylation modulators for targeted therapeuticsCU24204Engineered depalmitoylases selectively disrupt NRas signaling, enabling inducible, targeted palmitoylation control for cancer and neuro diseases.TagsCancerCell membraneCytotoxicityInventorsManu Ben-JohnySrinidhi JayaramanManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-20CollectionsOncology
Targeted Cdkn2a Suppression Therapy to Prevent Muscle Stem Cell Aging in SMA and MyopathiesCU23330Gene-targeted Cdkn2a suppression preserves muscle stem cell renewal, complementing SMN therapies for SMA and myopathies.TagsHigh-throughput screeningMyopathyNeuronInventorsNarendra JhaUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsNeurologyPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30CollectionsGene Therapy
Rapid assessment of T cell health for enhanced cancer immunotherapyCU24313A rapid platform uses biomaterials, imaging, and deep learning to assess T cell functionality and predict proliferation for immunotherapy.TagsAlgorithmAssayBiomaterialInventorsJia GuoLance KamNicole LamannaManagerDovina QuDepartmentsBiomedical EngineeringMedicinePsychiatryDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-12-18CollectionsArtificial Intelligence (AI)
MicroRNA markers for oral cancer prognosisCU20033MicroRNA-based 5-plex model predicts mortality risk in early-stage oral cancer, guiding personalized prognosis and treatment.TagsCancerDental degreeHead and neck cancerInventorsAngela J. YoonManagerJoan MartinezDepartmentsCollege of Dental MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2019-10-25CollectionsOncology
Predicting breast cancer treatment response through PIK3R1 mutation profilingCU26021Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.TagsAKT1AdenineBreast cancerInventorsNeil Vasan MD, PhDManagerJerry KokoshkaRelease Date2025-10-09
Riboswitch sensors to detect clinical biomarkersCU25097Real-time riboswitch–aptamer biosensors monitor creatine, urea, electrolytes for dynamic antibiotic dosing during kidney injury treatment.TagsAcute kidney injuryAntibioticAptamerInventorsMilan N. Stojanovic M.D.Nenad MilosavicSteven M.F. Kennedy TaylorManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchMedicineNephrologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-21
Ank3 E35 deletion mouse model for neuronal excitability researchCU26299Neuron-type Ank3 E35a deletion mouse enables precise study of interneuron excitability, calcium signaling, and psychiatric disease mechanisms.TagsAlternative splicingAutism spectrumBiomarkerInventorsChaolin Zhang PhDManagerJoan MartinezDepartmentsSystems BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-05-22
