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Medicine
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Combination therapy for the treatment of
melanoma
CU16039
Selective NF-kB c-Rel inhibitor plus immune checkpoint blockade boosts therapy for drug-resistant metastatic melanoma.
Tags
Cancer immunotherapy
Chemotherapy
Combination therapy
Inventors
Sankar Ghosh
Yenkel Grinberg-Bleyer
Manager
Cynthia Lang
Departments
Microbiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-05-24
Targeting senescent cells for the treatment of photoaging and
melanoma
CU25349
Senescent-cell–targeting therapy reverses photoaging and slows melanoma, offering dual cosmetic and oncologic benefits.
Tags
Cellular senescence
Chemotherapy
Hyperpigmentation
Inventors
Danial Khayatan
Rolando Perez-Lorenzo
Manager
Jerry Kokoshka
Departments
Dermatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-10-09
Dynein inhibition for enhanced anti-tumor
cytotoxicity
in solid tumors
CU24341
Dynein inhibition boosts natural killer cell cytotoxicity against solid tumors, enhancing immunotherapy efficacy across diverse microenvironments.
Tags
Adjuvant
Cytotoxic T cell
Dynein
Inventors
Jordan S. Orange MD, PhD
Manager
Jerry Kokoshka
Departments
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-11-20
MBOAT7-targeted therapies for the personalized treatment of NASH
fibrosis
CU22159
MBOAT7-targeted, personalized NASH therapy using rs641738 variant; MBOAT7 restoration and TAZ silencing reduce fibrosis.
Tags
Cirrhosis
Fibrosis
Gene therapy
Inventors
Ira Tabas MD, PhD
Mary Moore
Xiaobo Wang
Manager
Joan Martinez
Departments
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-18
3D organoids for modeling squamous epithelial pathology and personalized
medicine
CU22301
3D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.
Tags
Adenocarcinoma
Carcinoma
Epithelium
Inventors
Anil K. Rustgi M.D.
Hiroshi Nakagawa
Manager
Joan Martinez
Departments
Herbert Irving Comprehensive Cancer Center
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-04
Collections
Oncology
Computational method for brain tumor classification and improved
prognosis
CU21156
Integrates multi-omics to subtype glioblastoma, revealing four functional states and subtype-specific treatment targets.
Tags
Breast cancer
Glioblastoma
Glioma
Inventors
Anna Lasorella
Antonio Iavarone
Manager
Kristin Neuman
Departments
Neurology
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-01
Collections
Oncology
Targeting EGFR and IL-6 for the treatment of liver
fibrosis
and insulin resistance
CU23130
Targeting Treg-derived amphiregulin–EGFR axis and IL-6 to treat liver fibrosis and insulin resistance in MASH.
Tags
Biomarker
Crosstalk
Cytokine
Inventors
Nicholas Arpaia
Thomas Savage
Manager
Cynthia Lang
Departments
Microbiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-04-24
Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseases
CU23208
AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.
Tags
Amyotrophic lateral sclerosis
Gene expression
Gene therapy
Inventors
Emily Rhodes Lowry
Hynek Wichterle
Tulsi Patel
Manager
Jerry Kokoshka
Departments
Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-01-18
Collections
Gene Therapy
Targeted delivery of anti-microRNA for the treatment of liver
fibrosis
CU21066
Liver-targeted exosomes deliver anti-miR-132 to curb fibrosis, reducing collagen and pro-fibrotic signals with tissue specificity.
Tags
Cell membrane
Collagen
Fibrosis
Inventors
Akiva Mintz
Fatemeh Momen-Heravi
Manager
Joan Martinez
Departments
College of Dental Medicine
Radiology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-02
Generation of self-renewed CD4+ T cells for cancer and viral
disease
immunotherapy
CU24385
Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.
Tags
Antigen
Cell culture
Cell therapy
Inventors
Mithil Soni
Pawel Muranski
Prabesh Khatiwada
Manager
Jerry Kokoshka
Departments
Columbia Center for Translational Immunology
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-09-16
Targeted knock-in mouse line for studying neuropsychiatric
disease
CU26034
A knock-in mouse line enabling precise A2a-expressing neuron targeting in basal ganglia for neuropsychiatric research and drug validation.
Tags
Adenosine A2A receptor
Basal ganglia
Cre recombinase
Inventors
Rui Costa
Manager
Kristin Neuman
Departments
Neuroscience
Divisions
Zuckerman Mind Brain Behavior Inst
Release Date
2025-11-13
Human ALFY knock-in mice for studying neurodegenerative
disease
CU26143
Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.
Tags
Autophagy
Copy number variation
Cre recombinase
Inventors
Ai Yamamoto
Manager
Kristin Neuman
Departments
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Collections
CNS/Neurology
Conditional depletion of WDFY3 in murine models of
disease
CU26144
Engineered mouse with conditional WDFY3 knockout to study autophagy, mitophagy, efferocytosis, and neurodegenerative disease mechanisms.
Tags
Amino acid
Autism spectrum
Autophagy
Inventors
Ai Yamamoto
Manager
Kristin Neuman
Departments
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Collections
CNS/Neurology
Autophagy activating nucleotide sequence for neurodegenerative
disease
treatment
CU23286
Nucleotide sequence boosts ALFY (WDFY3) to enhance autophagic clearance of neurodegenerative protein aggregates.
Tags
Autophagy
Drug discovery
Gene
Inventors
Ai Yamamoto
Katherine R. Croce
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-12-20
Collections
CNS/Neurology
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's
disease
CU26032
Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.
Tags
Biomarker
Causality
Cre recombinase
Inventors
Rui Costa
Manager
Kristin Neuman
Departments
Neuroscience
Divisions
Zuckerman Mind Brain Behavior Inst
Release Date
2025-11-07
Ethyl pyruvate for the treatment of glaucoma and intraocular
disease
CU22343
Ethyl pyruvate stabilizes cellular energy, boosts antioxidant defenses, and provides neuroprotection for glaucoma and IOP-related diseases.
Tags
Anti-aging movement
Antioxidant
Cell membrane
Inventors
Nicholas Tolman
Simon John
Manager
Kristin Neuman
Departments
Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-09-19
Collections
Ophthalmology
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous system
CU22281
Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.
Tags
Central nervous system
Cholinergic
Gene expression
Inventors
Hynek Wichterle
Tulsi Patel
Manager
Jerry Kokoshka
Departments
Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-02
Collections
Gene Therapy
CNS/Neurology
In vivo internalizing RGD peptide production for enhanced treatment of solid tumors
CU25033
In vivo iRGD plasmid drives tumor penetration, reducing immunosuppression; co-administers with CAR-T/ therapies for enhanced efficacy.
Tags
Angiogenesis
Cancer immunotherapy
Chemotherapy
Inventors
Kazuki N. Sugahara
Norio Miyamura
Manager
Jerry Kokoshka
Departments
Surgery
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-11-20
Human-informed artificial intelligence system for enhanced eye
disease
detection
CU23260
Expert-eye-movement informed AI enhances glaucoma, AMD detection with interpretable, trainee-friendly, weakly supervised vision transformers.
Tags
Artificial intelligence
Convolutional neural network
Deep learning
Inventors
George Cioffi
Kaveri Thakoor
Manager
Dovina Qu
Departments
Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-04-21
Modulated protein for motor
neuron
disease
treatment
CU18201
Modulates Hspa8 to shift toward microautophagy, protecting neurons and delaying motor neuron disease progression. 15 words.
Tags
Amyotrophic lateral sclerosis
Chaperone (protein)
Heat shock protein
Inventors
Jeong Ki-Kim
Umrao R. Monani Ph.D.
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2019-08-21
Collections
CNS/Neurology
Efficient drug discovery pipeline and lead compounds for Alzheimer's
disease
CU23156
Multi-target Alzheimer’s drug discovery platform accelerates preclinical lead compounds with in vitro/in vivo efficacy and safety.
Tags
Agonist
Amyloid beta
Animal testing
Inventors
Caghan Kizil
Manager
Joan Martinez
Departments
Neurology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-10
Collections
Small Molecule
CNS/Neurology
Platform/Research Tool
Alzheimer's
disease
detection and treatment based on ceramide and sphingolipid levels
CU15147
Gene-targeted reduction of ER-MAM APP-C99 via ceramide/sphingolipid biomarkers enables early Alzheimer’s detection and therapeutic modulation.
Tags
Amyloid beta
Biomarker
Cell membrane
Inventors
Eric A. Schon Ph.D.
Estela Area-Gomez
Manager
Kristin Neuman
Departments
Neurology
Divisions
College of Physicians and Surgeons (CUMC
Columbia University Medical Center (CUMC)
Release Date
2024-04-25
Collections
CNS/Neurology
Modular, multi-tissue system for
in vitro
modeling of systemic
disease
CU19102
Multi-tissue organ-on-a-chip platform enables vascular-coupled, patient-specific modeling of systemic disease and cancer metastasis.
Tags
Circulatory system
Crosstalk
Endothelium
Inventors
Alan Chramiec
Andrea Califano Ph.D.
Ece Ozturk
Manager
Cynthia Lang
Departments
Biochemistry & Molecular Biophysics
Biomedical Engineering
Biomedical Informatics
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-10-31
Collections
Oncology
Platform/Research Tool
Hormone therapy for age-related frailty and muscle degeneration
CU15011
Osteocalcin-based hormone therapy aims to reverse age-related frailty, muscle loss, and linked metabolic, reproductive, and cognitive disorders.
Tags
Anxiety
Apoptosis
Asthma
Inventors
Gerard Karsenty M.D., Ph.D.
Paula Mera
Manager
Jerry Kokoshka
Departments
Genetics & Development
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-08-29
Modified peptide nucleic acids for highly specific suppression of oncogene transcription
CU19272
Modified peptide nucleic acids deliver tumor-specific transcription suppression with reduced off-target toxicity for KRAS-driven cancers.
Tags
Chemotherapy
Cytotoxicity
KRAS
Inventors
Jeffrey Rothman
Manager
Joan Martinez
Departments
Oncology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-06-18
Method to Enhance Optical Coherence Tomography (OCT) for Eye
Disease
Detection
CU22266
AI-enhanced portable OCT improves image quality and automatically detects AMD, enabling low-cost, accessible eye disease screening.
Tags
Internal medicine
Macular degeneration
Natural disaster
Inventors
Christine P. Hendon
Desmond Yao
Donald Charles Hood
Manager
Dovina Qu
Departments
Biomedical Engineering
Electrical Engineering
Ophthalmology
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2023-02-20
Collections
Ophthalmology
Medical Device
Digital Health (Software, AI, bioinformatics, etc)
Targeting Delta-2 tubulin for the treatment of peripheral neuropathy
CU25119
Delta-2 tubulin as a therapeutic target to prevent or treat chemotherapy-induced peripheral neuropathy, addressing multiple drug classes.
Tags
Analgesic
Anticonvulsant
Antidepressant
Inventors
Francesca Bartolini Ph.D.
Maria Elena Pero
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2025-12-17
Collections
CNS/Neurology
Riboswitch sensors to detect clinical biomarkers
CU25097
Real-time riboswitch–aptamer biosensors monitor creatine, urea, electrolytes for dynamic antibiotic dosing during kidney injury treatment.
Tags
Acute kidney injury
Antibiotic
Aptamer
Inventors
Milan N. Stojanovic M.D.
Nenad Milosavic
Steven M.F. Kennedy Taylor
Manager
Jerry Kokoshka
Departments
Herbert and Florence Irving Center for Clinical Research
Medicine
Nephrology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-08-21
Palmitoylation modulators for targeted therapeutics
CU24204
Engineered depalmitoylases selectively disrupt NRas signaling, enabling inducible, targeted palmitoylation control for cancer and neuro diseases.
Tags
Cancer
Cell membrane
Cytotoxicity
Inventors
Manu Ben-Johny
Srinidhi Jayaraman
Manager
Kristin Neuman
Departments
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-02-20
Collections
Oncology
MicroRNA markers for oral cancer
prognosis
CU20033
MicroRNA-based 5-plex model predicts mortality risk in early-stage oral cancer, guiding personalized prognosis and treatment.
Tags
Cancer
Dental degree
Head and neck cancer
Inventors
Angela J. Yoon
Manager
Joan Martinez
Departments
College of Dental Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2019-10-25
Collections
Oncology
Peptide targeting CD33 to treat cognitive decline in Alzheimer's
Disease
patients
CU21001
A cost-effective peptide disrupts CD33-CD45, activates microglia, reduces amyloid, potentially slowing cognitive decline in Alzheimer's.
Tags
Acetylcholinesterase
Acute myeloid leukemia
Amyloid
Inventors
Elizabeth M. Bradshaw
Wassim Elyaman
Manager
Joan Martinez
Departments
Neurology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-02-02
Collections
CNS/Neurology
Generation of mature neurons differentiated from differentiated stem cells by manipulating RNA splicing
CU24262
Accelerates maturation of iPSC-derived neurons by boosting Mbnl2 splicing, enabling adult-like models for neurodegenerative diseases.
Tags
Alternative splicing
Brain
Development of the nervous system
Inventors
Brian Jude Joseph
Chaolin Zhang PhD
Hynek Wichterle
Manager
Joan Martinez
Departments
Biochemistry & Molecular Biophysics
Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-16
Machine learning tool for diagnosis of cutaneous T-cell lymphoma (CTCL)
CU24366
AI-powered CTCL diagnosis tool links genetic markers with EHR data to improve accuracy, staging, and prognosis.
Tags
Assay
Cancer
Cutaneous T cell lymphoma
Inventors
Larisa Geskin
Manager
Cynthia Lang
Departments
Dermatology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-01-30
Treatment of systolic heart failure without increased heart
rate
(tachycardia)
CU19251
Small-molecule protein therapy boosts cardiac contractility by raising calcium without increasing heart rate, reducing tachycardia risk.
Tags
Biopharmaceutical
Blood pressure
Cardiac arrest
Inventors
Alexander Kushnir
Arianne Papa
Guoxia Liu
Manager
Joan Martinez
Departments
Cardiology
Medicine
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-11-03
Collections
Small Molecule
Cardiovascular
Small molecule inhibitors of the ID2/VHL interaction
CU17182
Four small molecules block ID2/VHL, promote HIF degradation, potentially slowing tumor growth and angiogenesis in cancers.
Tags
Angiogenesis
Cell growth
Chemotherapy
Inventors
Anna Lasorella
Antonio Iavarone
Dan Sherman
Manager
Kristin Neuman
Departments
Institute for Cancer Genetics
Neurology
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-19
Collections
Small Molecule
Oncology
Injectable hydrogels for therapeutic delivery
CU25086
Injectable, biocompatible hydrogels crosslinked by extracellular vesicles for bioactive, scalable regenerative therapy delivery.
Tags
Biocompatibility
Biomaterial
Cellulose
Inventors
Artemis Margaronis
Caterina Piunti
Cindy Huilin Lu
Manager
Dovina Qu
Departments
Biomedical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-07-15
Virtual reality platform for upper limb motor rehabilitation
CU25025
VR platform for unconstrained upper-limb rehabilitation, enabling natural-movement tasks to improve motor function and real-world readiness.
Tags
Motor control
Neuron
Virtual reality
Inventors
Robert Carrera
Sunil K. Agrawal
Manager
Dovina Qu
Departments
Biomedical Engineering
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-07-29
Lipid targets and biomarkers for ferroptosis
CU24174
Lipid biomarkers (PC-PUFA2s) drive ferroptosis; enables diagnostics and targeted therapies by regulating iron-dependent cell death.
Tags
Acyl group
Apoptosis
Biomarker
Inventors
Baiyu Qiu
Brent Stockwell
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2024-12-20
WDFY3 variant mouse models for neurodegenerative studies
CU26145
A clinically relevant WDFY3 knock-in mouse model to study autophagy’s role in neurodegenerative diseases and therapies.
Tags
Autophagy
Neurodegenerative disease
Neuron
Inventors
Ai Yamamoto
Manager
Kristin Neuman
Departments
Physiology and Cellular Biophysics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Drug-resistant pancreatic cancer cell lines for drug testing
CU25070
Pan-RAS-GTP resistant PDAC cell lines enable in vitro drug testing and resistance mechanism study on RAS inhibitors.
Tags
Chemotherapy
Drug discovery
Drug resistance
Inventors
Kenneth P. Olive Ph.D.
Manager
Joan Martinez
Departments
Herbert Irving Comprehensive Cancer Center
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-12-06
Method to augment efferocytosis for treatment of autoimmune diseases
CU23287
Augments macrophage efferocytosis by activating WDFY3 to reduce autoimmune inflammation across multiple diseases.
Tags
Apoptosis
Asthma
Atherosclerosis
Inventors
Ai Yamamoto
Hanrui Zhang
Katherine R. Croce
Manager
Kristin Neuman
Departments
Cardiology
Medicine
Pathology & Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2024-07-05
Immature myeloid cell activation pathway in inflammation-linked cancer
CU26121
IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.
Tags
Angiogenesis
Biomarker
Bone marrow
Inventors
Timothy Wang M.D.
Manager
Jerry Kokoshka
Departments
Herbert and Florence Irving Center for Clinical Research
Divisions
Columbia University Medical Center (CUMC)
Release Date
2026-01-08
Novel prognostic marker for survival in myeloid malignancies
CU18296
Multi-gene transcriptomic classifier using TED markers to predict MDS progression to AML, enabling earlier, accurate prognosis.
Tags
Acute myeloid leukemia
Assay
Gene expression
Inventors
Abdullah Ali Ph.D.
Azra Raza M.D.
Etienne De Clara
Manager
Joan Martinez
Departments
Herbert Irving Comprehensive Cancer Center
Medical Oncology
Medicine
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-05-28
Gene therapy for metabolic dysfunction-associated steatohepatitis (MASH)
CU25230
Gene therapy restoring retromer activity to treat MASH by normalizing lipid metabolism and reducing fibrosis risk.
Tags
Cirrhosis
Drug discovery
Fibrosis
Inventors
Gregory A. Petsko
Scott A. Small M.D.
Manager
Jerry Kokoshka
Departments
Ann Romney Center for Neurologic Diseases
Neurology
Divisions
Columbia University Medical Center (CUMC)
Harvard Medical School and Brigham & Women’s Hospital
Release Date
2025-07-31
Targeting ID2 to impair hypoxic cancer stem cell proliferation
CU16166
Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.
Tags
Angiogenesis
Cancer stem cell
Cell proliferation
Inventors
Anna Lasorella
Antonio Iavarone
Manager
Kristin Neuman
Departments
Neurology
Pediatrics
Divisions
Columbia University Medical Center (CUMC)
Release Date
2023-05-19
Collections
Oncology
Non-invasive laser therapy for cytokine modulation and corneal inflammation management
CU18315
Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.
Tags
Analgesic
Antibiotic
Apoptosis
Inventors
Sinisa Vukelic
Manager
Dovina Qu
Departments
Mechanical Engineering
Divisions
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2024-08-17
Collections
Ophthalmology
A2a-FlpO mouse model for neuroscience studies
CU26036
Precise, cell-type specific A2a-FlpO knock-in mice enable orthogonal D1/D2 dopaminergic studies in basal ganglia circuits.
Tags
Basal ganglia
Behavioral neuroscience
Combinatorics
Inventors
Rui Costa
Manager
Kristin Neuman
Departments
Neuroscience
Divisions
Zuckerman Mind Brain Behavior Inst
Release Date
2025-11-13
Calibration-free affinity biosensors for rapid, accurate biomarker detection
CU22223
Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.
Tags
Aptamer
Biomarker
Biosensor
Inventors
Milan N. Stojanovic M.D.
Qiao Lin
Wenting Dai
Manager
Dovina Qu
Departments
Mechanical Engineering
Medicine
Divisions
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2025-08-21
Combinatorial treatment for amyotrophic lateral sclerosis (ALS)
CU25447
Combinatorial ASO therapy targets 15 dysregulated genes in SOD1-ALS, mitigating neuron death and boosting motor function.
Tags
Amyotrophic lateral sclerosis
Biomarker
Combinatorics
Inventors
George Z. Mentis Ph.D.
JoonHyung Park
Manager
Jerry Kokoshka
Departments
Pathology & Cell Biology
Pathology and Cell Biology
Divisions
Columbia University Medical Center (CUMC)
Release Date
2025-07-29
GPX4 inhibitors for cancer therapy
CU20261
Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.
Tags
Active site
Allosteric regulation
Apoptosis
Inventors
Brent Stockwell
Hengrui Liu
Manager
Joan Martinez
Departments
Biological Sciences
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2025-05-01
