Combination therapy for the treatment of melanomaCU16039Selective NF-kB c-Rel inhibitor plus immune checkpoint blockade boosts therapy for drug-resistant metastatic melanoma.TagsCancer immunotherapyChemotherapyCombination therapyInventorsSankar GhoshYenkel Grinberg-BleyerManagerCynthia LangDepartmentsMicrobiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-05-24
Targeting senescent cells for the treatment of photoaging and melanomaCU25349Senescent-cell–targeting therapy reverses photoaging and slows melanoma, offering dual cosmetic and oncologic benefits.TagsCellular senescenceChemotherapyHyperpigmentationInventorsDanial KhayatanRolando Perez-LorenzoManagerJerry KokoshkaDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-10-09
Dynein inhibition for enhanced anti-tumor cytotoxicity in solid tumorsCU24341Dynein inhibition boosts natural killer cell cytotoxicity against solid tumors, enhancing immunotherapy efficacy across diverse microenvironments.TagsAdjuvantCytotoxic T cellDyneinInventorsJordan S. Orange MD, PhDManagerJerry KokoshkaDepartmentsPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
3D organoids for modeling squamous epithelial pathology and personalized medicineCU223013D squamous epithelial organoids enable patient-specific disease modeling and rapid, predictive drug testing for ESCC/EAC.TagsAdenocarcinomaCarcinomaEpitheliumInventorsAnil K. Rustgi M.D.Hiroshi NakagawaManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-04CollectionsOncology
Computational method for brain tumor classification and improved prognosisCU21156Integrates multi-omics to subtype glioblastoma, revealing four functional states and subtype-specific treatment targets.TagsBreast cancerGlioblastomaGliomaInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-01CollectionsOncology
Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseasesCU23208AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.TagsAmyotrophic lateral sclerosisGene expressionGene therapyInventorsEmily Rhodes LowryHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-01-18CollectionsGene Therapy
Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapyCU24385Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.TagsAntigenCell cultureCell therapyInventorsMithil SoniPawel MuranskiPrabesh KhatiwadaManagerJerry KokoshkaDepartmentsColumbia Center for Translational ImmunologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2024-09-16
Targeted knock-in mouse line for studying neuropsychiatric diseaseCU26034A knock-in mouse line enabling precise A2a-expressing neuron targeting in basal ganglia for neuropsychiatric research and drug validation.TagsAdenosine A2A receptorBasal gangliaCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Human ALFY knock-in mice for studying neurodegenerative diseaseCU26143Human ALFY knock-in mice enable tissue-specific, controllable hALFY expression to study neurodegenerative protein aggregation.TagsAutophagyCopy number variationCre recombinaseInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Conditional depletion of WDFY3 in murine models of diseaseCU26144Engineered mouse with conditional WDFY3 knockout to study autophagy, mitophagy, efferocytosis, and neurodegenerative disease mechanisms.TagsAmino acidAutism spectrumAutophagyInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08CollectionsCNS/Neurology
Autophagy activating nucleotide sequence for neurodegenerative disease treatmentCU23286Nucleotide sequence boosts ALFY (WDFY3) to enhance autophagic clearance of neurodegenerative protein aggregates.TagsAutophagyDrug discoveryGeneInventorsAi YamamotoKatherine R. CroceManagerKristin NeumanDepartmentsPathology & Cell BiologyPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2024-12-20CollectionsCNS/Neurology
Anxa1-Cre mouse for selective modeling of dopaminergic neurons in Parkinson's diseaseCU26032Anxa1-Cre mouse enables precise manipulation of a vulnerable dopaminergic neuron subtype to study early Parkinson’s motor deficits.TagsBiomarkerCausalityCre recombinaseInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-07
Ethyl pyruvate for the treatment of glaucoma and intraocular diseaseCU22343Ethyl pyruvate stabilizes cellular energy, boosts antioxidant defenses, and provides neuroprotection for glaucoma and IOP-related diseases.TagsAnti-aging movementAntioxidantCell membraneInventorsNicholas TolmanSimon JohnManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-09-19CollectionsOphthalmology
Human-informed artificial intelligence system for enhanced eye disease detectionCU23260Expert-eye-movement informed AI enhances glaucoma, AMD detection with interpretable, trainee-friendly, weakly supervised vision transformers.TagsArtificial intelligenceConvolutional neural networkDeep learningInventorsGeorge CioffiKaveri ThakoorManagerDovina QuDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-04-21
Preventive therapeutic of stress-induced psychiatric disordersCU21050Prophylactic VPAC2 agonist treatment prevents stress-induced fear, anxiety, and depression-like behaviors, boosting resilience in mice.TagsPost-traumatic stress disorderPreventive healthcarePsychiatryInventorsBriana Kaying ChenChristine Ann DennyManagerCynthia LangDepartmentsCENTER OF NEUROBIOLOGY AND BEHAVIORPsychiatryDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-05
A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous systemCU22281Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.TagsCentral nervous systemCholinergicGene expressionInventorsHynek WichterleTulsi PatelManagerJerry KokoshkaDepartmentsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-02CollectionsGene TherapyCNS/Neurology
Efficient drug discovery pipeline and lead compounds for Alzheimer's diseaseCU23156Multi-target Alzheimer’s drug discovery platform accelerates preclinical lead compounds with in vitro/in vivo efficacy and safety.TagsAgonistAmyloid betaAnimal testingInventorsCaghan KizilManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-10CollectionsSmall MoleculeCNS/NeurologyPlatform/Research Tool
Alzheimer's disease detection and treatment based on ceramide and sphingolipid levelsCU15147Gene-targeted reduction of ER-MAM APP-C99 via ceramide/sphingolipid biomarkers enables early Alzheimer’s detection and therapeutic modulation.TagsAmyloid betaBiomarkerCell membraneInventorsEric A. Schon Ph.D.Estela Area-GomezManagerKristin NeumanDepartmentsNeurologyDivisionsCollege of Physicians and Surgeons (CUMCColumbia University Medical Center (CUMC)Release Date2024-04-25CollectionsCNS/Neurology
In vivo internalizing RGD peptide production for enhanced treatment of solid tumorsCU25033In vivo iRGD plasmid drives tumor penetration, reducing immunosuppression; co-administers with CAR-T/ therapies for enhanced efficacy.TagsAngiogenesisCancer immunotherapyChemotherapyInventorsKazuki N. SugaharaNorio MiyamuraManagerJerry KokoshkaDepartmentsSurgeryDivisionsColumbia University Medical Center (CUMC)Release Date2025-11-20
Modular, multi-tissue system for in vitro modeling of systemic diseaseCU19102Multi-tissue organ-on-a-chip platform enables vascular-coupled, patient-specific modeling of systemic disease and cancer metastasis.TagsCirculatory systemCrosstalkEndotheliumInventorsAlan ChramiecAndrea Califano Ph.D.Ece OzturkManagerCynthia LangDepartmentsBiochemistry & Molecular BiophysicsBiomedical EngineeringBiomedical InformaticsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-10-31CollectionsOncologyPlatform/Research Tool
Modulated protein for motor neuron disease treatmentCU18201Modulates Hspa8 to shift toward microautophagy, protecting neurons and delaying motor neuron disease progression. 15 words.TagsAmyotrophic lateral sclerosisChaperone (protein)Heat shock proteinInventorsJeong Ki-KimUmrao R. Monani Ph.D.ManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2019-08-21CollectionsCNS/Neurology
Targeting Delta-2 tubulin for the treatment of peripheral neuropathyCU25119Delta-2 tubulin as a therapeutic target to prevent or treat chemotherapy-induced peripheral neuropathy, addressing multiple drug classes.TagsAnalgesicAnticonvulsantAntidepressantInventorsFrancesca Bartolini Ph.D.Maria Elena PeroManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17CollectionsCNS/Neurology
Modified peptide nucleic acids for highly specific suppression of oncogene transcriptionCU19272Modified peptide nucleic acids deliver tumor-specific transcription suppression with reduced off-target toxicity for KRAS-driven cancers.TagsChemotherapyCytotoxicityKRASInventorsJeffrey RothmanManagerJoan MartinezDepartmentsOncologyDivisionsColumbia University Medical Center (CUMC)Release Date2024-06-18
Method to Enhance Optical Coherence Tomography (OCT) for Eye Disease DetectionCU22266AI-enhanced portable OCT improves image quality and automatically detects AMD, enabling low-cost, accessible eye disease screening.TagsInternal medicineMacular degenerationNatural disasterInventorsChristine P. HendonDesmond YaoDonald Charles HoodManagerDovina QuDepartmentsBiomedical EngineeringElectrical EngineeringOphthalmologyDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesFu Foundation School of Engineering and Applied Science (SEAS)Release Date2023-02-20CollectionsOphthalmologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Riboswitch sensors to detect clinical biomarkersCU25097Real-time riboswitch–aptamer biosensors monitor creatine, urea, electrolytes for dynamic antibiotic dosing during kidney injury treatment.TagsAcute kidney injuryAntibioticAptamerInventorsMilan N. Stojanovic M.D.Nenad MilosavicSteven M.F. Kennedy TaylorManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchMedicineNephrologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-21
Palmitoylation modulators for targeted therapeuticsCU24204Engineered depalmitoylases selectively disrupt NRas signaling, enabling inducible, targeted palmitoylation control for cancer and neuro diseases.TagsCancerCell membraneCytotoxicityInventorsManu Ben-JohnySrinidhi JayaramanManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2025-02-20CollectionsOncology
Peptide targeting CD33 to treat cognitive decline in Alzheimer's Disease patientsCU21001A cost-effective peptide disrupts CD33-CD45, activates microglia, reduces amyloid, potentially slowing cognitive decline in Alzheimer's.TagsAcetylcholinesteraseAcute myeloid leukemiaAmyloidInventorsElizabeth M. BradshawWassim ElyamanManagerJoan MartinezDepartmentsNeurologyDivisionsColumbia University Medical Center (CUMC)Release Date2023-02-02CollectionsCNS/Neurology
Machine learning tool for diagnosis of cutaneous T-cell lymphoma (CTCL)CU24366AI-powered CTCL diagnosis tool links genetic markers with EHR data to improve accuracy, staging, and prognosis.TagsAssayCancerCutaneous T cell lymphomaInventorsLarisa GeskinManagerCynthia LangDepartmentsDermatologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-30
Generation of mature neurons differentiated from differentiated stem cells by manipulating RNA splicingCU24262Accelerates maturation of iPSC-derived neurons by boosting Mbnl2 splicing, enabling adult-like models for neurodegenerative diseases.TagsAlternative splicingBrainDevelopment of the nervous systemInventorsBrian Jude JosephChaolin Zhang PhDHynek WichterleManagerJoan MartinezDepartmentsBiochemistry & Molecular BiophysicsCenter for Neurobiology & BehaviorPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-01-16
Treatment of systolic heart failure without increased heart rate (tachycardia)CU19251Small-molecule protein therapy boosts cardiac contractility by raising calcium without increasing heart rate, reducing tachycardia risk.TagsBiopharmaceuticalBlood pressureCardiac arrestInventorsAlexander KushnirArianne PapaGuoxia LiuManagerJoan MartinezDepartmentsCardiologyMedicinePhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2023-11-03CollectionsSmall MoleculeCardiovascular
MicroRNA markers for oral cancer prognosisCU20033MicroRNA-based 5-plex model predicts mortality risk in early-stage oral cancer, guiding personalized prognosis and treatment.TagsCancerDental degreeHead and neck cancerInventorsAngela J. YoonManagerJoan MartinezDepartmentsCollege of Dental MedicineDivisionsColumbia University Medical Center (CUMC)Release Date2019-10-25CollectionsOncology
Small molecule inhibitors of the ID2/VHL interactionCU17182Four small molecules block ID2/VHL, promote HIF degradation, potentially slowing tumor growth and angiogenesis in cancers.TagsAngiogenesisCell growthChemotherapyInventorsAnna LasorellaAntonio IavaroneDan ShermanManagerKristin NeumanDepartmentsInstitute for Cancer GeneticsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsSmall MoleculeOncology
Injectable hydrogels for therapeutic deliveryCU25086Injectable, biocompatible hydrogels crosslinked by extracellular vesicles for bioactive, scalable regenerative therapy delivery.TagsBiocompatibilityBiomaterialCelluloseInventorsArtemis MargaronisCaterina PiuntiCindy Huilin LuManagerDovina QuDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-15
Virtual reality platform for upper limb motor rehabilitationCU25025VR platform for unconstrained upper-limb rehabilitation, enabling natural-movement tasks to improve motor function and real-world readiness.TagsMotor controlNeuronVirtual realityInventorsRobert CarreraSunil K. AgrawalManagerDovina QuDepartmentsBiomedical EngineeringMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-07-29
WDFY3 variant mouse models for neurodegenerative studiesCU26145A clinically relevant WDFY3 knock-in mouse model to study autophagy’s role in neurodegenerative diseases and therapies.TagsAutophagyNeurodegenerative diseaseNeuronInventorsAi YamamotoManagerKristin NeumanDepartmentsPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Hormone therapy for age-related frailty and muscle degenerationCU15011Osteocalcin-based hormone therapy aims to reverse age-related frailty, muscle loss, and linked metabolic, reproductive, and cognitive disorders.TagsAnxietyApoptosisAsthmaInventorsGerard Karsenty M.D., Ph.D.Paula MeraManagerJerry KokoshkaDepartmentsGenetics & DevelopmentDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
Calibration-free affinity biosensors for rapid, accurate biomarker detectionCU22223Calibration-free graphene FET biosensor uses aptamer kinetics for rapid, device-wide reproducible biomarker detection without per-sensor calibration.TagsAptamerBiomarkerBiosensorInventorsMilan N. Stojanovic M.D.Qiao LinWenting DaiManagerDovina QuDepartmentsMechanical EngineeringMedicineDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2025-08-21
Immature myeloid cell activation pathway in inflammation-linked cancerCU26121IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.TagsAngiogenesisBiomarkerBone marrowInventorsTimothy Wang M.D.ManagerJerry KokoshkaDepartmentsHerbert and Florence Irving Center for Clinical ResearchDivisionsColumbia University Medical Center (CUMC)Release Date2026-01-08
Engineered probiotics for safe and targeted cancer vaccinesCU25192Engineered bacteria deliver tumor neoantigens to solid tumors, boosting targeted, durable immunotherapy with minimal dosing.TagsAntigenBacteriaCancer immunotherapyInventorsJongwon ImTal DaninoManagerCynthia LangDepartmentsBiomedical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2026-03-27
Drug-resistant pancreatic cancer cell lines for drug testingCU25070Pan-RAS-GTP resistant PDAC cell lines enable in vitro drug testing and resistance mechanism study on RAS inhibitors.TagsChemotherapyDrug discoveryDrug resistanceInventorsKenneth P. Olive Ph.D.ManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterDivisionsColumbia University Medical Center (CUMC)Release Date2024-12-06
Novel prognostic marker for survival in myeloid malignanciesCU18296Multi-gene transcriptomic classifier using TED markers to predict MDS progression to AML, enabling earlier, accurate prognosis.TagsAcute myeloid leukemiaAssayGene expressionInventorsAbdullah Ali Ph.D.Azra Raza M.D.Etienne De ClaraManagerJoan MartinezDepartmentsHerbert Irving Comprehensive Cancer CenterMedical OncologyMedicineDivisionsColumbia University Medical Center (CUMC)Release Date2025-05-28
Non-invasive laser therapy for cytokine modulation and corneal inflammation managementCU18315Femtosecond laser therapy non-invasively modulates corneal cytokines to reduce inflammation and keratocyte apoptosis, preserving tissue.TagsAnalgesicAntibioticApoptosisInventorsSinisa VukelicManagerDovina QuDepartmentsMechanical EngineeringDivisionsFu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-08-17CollectionsOphthalmology
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsActive siteAllosteric regulationApoptosisInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Inhibition of RAR/RXR signaling for adenoid cystic carcinoma treatmentCU23276Targeted ACC therapy modulates RAR/RXR signaling to reclassify tumor cells and selectively kill ductal-like populations.TagsAdenocarcinomaAdenoidAdjuvant therapyInventorsPierangela PalmeriniPiero D. DalerbaSara ViragovaManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2026-03-13
Targeting ID2 to impair hypoxic cancer stem cell proliferationCU16166Targeting ID2–DYRK1A/B axis degrades HIF2a in hypoxic cancer stem cells, offering glioblastoma–focused, broad oncologic potential.TagsAngiogenesisCancer stem cellCell proliferationInventorsAnna LasorellaAntonio IavaroneManagerKristin NeumanDepartmentsNeurologyPediatricsDivisionsColumbia University Medical Center (CUMC)Release Date2023-05-19CollectionsOncology
Orally administered drug with extended release for obesity treatmentCU23375Oral, extended-release nanoparticle drug LIGNOCAL delivers lipocalin-2 to suppress appetite, boost metabolism, and aid obesity/diabetes treatment.TagsAnorecticBioavailabilityBiological half-lifeInventorsJessica DeAngelisKam LeongStavroula KousteniManagerJerry KokoshkaDepartmentsBiomedical EngineeringHerbert and Florence Irving Center for Clinical ResearchPhysiology and Cellular BiophysicsDivisionsColumbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2024-11-26
A2a-FlpO mouse model for neuroscience studiesCU26036Precise, cell-type specific A2a-FlpO knock-in mice enable orthogonal D1/D2 dopaminergic studies in basal ganglia circuits.TagsBasal gangliaBehavioral neuroscienceCombinatoricsInventorsRui CostaManagerKristin NeumanDepartmentsNeuroscienceDivisionsZuckerman Mind Brain Behavior InstRelease Date2025-11-13
Treating elevated intraocular pressure with nicotinamide and its analogsCU23299Nicotinamide-based oral therapy lowers intraocular pressure, potentially preventing glaucoma progression with easy, non-invasive administration.TagsAnti-aging movementGlaucomaIntraocular pressureInventorsNicholas TolmanSimon JohnStephen C. KneelandManagerKristin NeumanDepartmentsOphthalmologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-09-12CollectionsOphthalmology
Combinatorial treatment for amyotrophic lateral sclerosis (ALS)CU25447Combinatorial ASO therapy targets 15 dysregulated genes in SOD1-ALS, mitigating neuron death and boosting motor function.TagsAmyotrophic lateral sclerosisBiomarkerCombinatoricsInventorsGeorge Z. Mentis Ph.D.JoonHyung ParkManagerJerry KokoshkaDepartmentsPathology & Cell BiologyPathology and Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-07-29
Convection-enhanced delivery of topotecan and dexamethasone for malignant gliomasCU25031Implantable pump enables chronic, targeted brain delivery of topotecan plus dexamethasone via convection-enhanced delivery for glioma.TagsAdjuvant therapyAnimal disease modelBlood–brain barrierInventorsJeffrey BrucePeter CanollManagerJerry KokoshkaDepartmentsNeurological SurgeryPathology & Cell BiologyDivisionsColumbia University Medical Center (CUMC)Release Date2025-08-29
