Conditional knockout mouse model for the Phf6 geneCU22370A tissue-specific Phf6 conditional knockout mouse model for studying Börjeson-Forssman-Lehmann syndrome and hematologic cancers.TagsAcute myeloid leukemiaGeneHigh-throughput screeningInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2022-08-20
Treatment for Alzheimer's Disease-related memory lossCU13335Selective PDE4D inhibitors improve AD memory with fewer side effects, offering low-dose, targeted cognitive benefits.TagsAmyloid betaBrainCerebral cortexInventorsErnesto FedeleJos PrickaertsMauro FaManagerJerry KokoshkaDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2018-05-11
Preclinical models of angioimmunoblastic T-cell lymphoma for therapeutic investigationCU23322RhoA G17V-driven mouse model of angioimmunoblastic T-cell lymphoma enables translational drug screening and pathogenesis study.TagsCancer cellChemotherapyGene expressionInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-06-15CollectionsOncology
Non-invasive imaging analysis for predicting lung adenocarcinoma subtypesCU20338Noninvasive CT-based AI platform quantifying tumor imaging biomarkers to predict lung adenocarcinoma subtypes and prognosis.TagsAdenocarcinomaAssayBiomarkerInventorsBinsheng ZhaoLarry SchwartzLin LuManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2020-10-15CollectionsOncologyPlatform/Research Tool
Delta-2 tubulin for detection and treatment of peripheral neuropathyCU18162Delta-2 tubulin biomarker enables CIPN diagnosis and targeted prevention/treatment, plus drug screening for prophylactic therapies.TagsAnticonvulsantBiomarkerChemotherapyInventorsFrancesca Bartolini Ph.D.Guido CavalettiMaria Elena PeroManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2019-07-15
Multiplexed T cell profiling for generating engineered regulatory T cell therapiesCU23310High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.TagsAmyotrophic lateral sclerosisAntigenCRISPRInventorsElizabeth M. BradshawNeil ShneiderRyan HobsonManagerJoan MartinezDepartmentsMolecular MedicineNeurologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-01-02
Video-guided bedside thoracoscopy systemCU24084Video-guided bedside thoracoscopy enables safer, faster chest tube placement with real-time feedback and bedside diagnostics.TagsBiopsyCT scanChest tubeInventorsJosh SonnetMorgan MoroiRobert CrumManagerSara GusikDepartmentsSurgeryDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2024-07-18
Adjustable repositioning of lung blocks for total body irradiationCU21114Adjustable lung-block holder enhances precise, multi-axis repositioning during total body irradiation, boosting efficiency and reducing lung exposure.TagsLungInventorsCarl EllistonDavid P. HorowitzGary W. JohnsonManagerJerry KokoshkaDepartmentsRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2020-12-13CollectionsOncology
Panoramic cone beam computed tomography (CBCT) obtains full-scan CT images using only a half-scan rotation2934Half-scan panoramic CBCT reconstructs full volumetric images from 180-degree data, boosting efficiency, reducing dose, compatible with existing scanners.TagsImage stitchingLaserMedical physicsInventorsJenghwa ChangK.S. Clifford ChaoLili ZhouManagerOrin HerskowitzDepartmentsRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Release Date2013-09-03
Automated medical imaging method for optimized portal venous phase acquisitionCU18342Automated CNN-based portal venous phase tuning improves tumor vascular density and volume assessment, enabling unbiased treatment response monitoring.TagsAlgorithmAngiogenesisAortaInventorsBinsheng ZhaoJingchen MaLarry SchwartzManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2019-10-17CollectionsOncology
TLX1 mouse model recapitulates clinical symptoms of T cell acute lymphoblastic leukemiaCU23147TLX1 transgenic mouse models human T-ALL, mirroring clinical progression to study pathogenesis, microenvironment, and drug responses.TagsAcute lymphoblastic leukemiaAneuploidyAortic dissectionInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-04-15CollectionsOncology
Ferroptosis inducers as radiosensitizers for improved cancer treatmentCU19410Ferroptosis-inducing radiosensitizers boost radiation therapy by non-apoptotic cancer cell death, overcoming resistance.TagsApoptosisDNA repairEnzyme inducerInventorsBrent StockwellLing YeSimon Cheng M.D., Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Faculty of the Arts & SciencesRelease Date2022-08-05CollectionsSmall MoleculeOncology
A platform for development and validation of imaging biomarkers in oncologyCU20185A scalable, open-platform for developing, validating, and applying quantitative imaging biomarkers to monitor tumor response across cancers.TagsBiomarkerCancer immunotherapyDrug developmentInventorsBinsheng ZhaoHao YangLarry SchwartzManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2020-03-03CollectionsOncologyPlatform/Research Tool
Functional hand orthosis for stroke patientsCU15139A wearable, self-contained glove using motors and tendons restores dexterous hand movement for daily activities in stroke recovery.TagsAlgorithmLightweightMotor cortexInventorsJoel Stein M.D.Matei CiocarlieManagerSara GusikDepartmentsMechanical EngineeringRehabilitation and Regenerative MedicineDivisionsCollege of Physicians and Surgeons (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-04-08
Specialized diet for enhanced cancer treatmentCU21118Amino acid-restricted diet enhances chemotherapy/radiation efficacy by selectively targeting cancer cells while maintaining energy needs.TagsAmino acidChemotherapyGliomaInventorsBrent StockwellDominique HigginsJeffrey BruceManagerJerry KokoshkaDepartmentsBiological SciencesNeurological SurgeryPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2020-11-05CollectionsOncology
Overcoming drug resistance in relapsed T-ALL patientsCU13051Mutated NT5C2 inhibitors counteract nucleoside-analog resistance in relapsed T-ALL, enabling first-line therapies and broader applicability.TagsAcute lymphoblastic leukemiaAcute myeloid leukemiaCancer cellInventorsAdolfo A. Ferrando M.D., Ph.D.Raul RabadanTeresa Palomero VasquezManagerJoan MartinezDepartmentsBiomedical InformaticsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2013-09-03
Selective COX-2 radioligands for PET imaging of neuroinflammationCU19254Fluorine-18 COX-2 PET radioligands enable noninvasive imaging of neuroinflammation with higher affinity and broad clinical reach.TagsAgonistCOX-2 inhibitorCelecoxibInventorsAkiva MintzJ. John MannJ.S. Dileep KumarManagerJerry KokoshkaDepartmentsPsychiatryRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17
Rapid, point-of-care assessment of radiation exposure in human bloodCU24211ELISA-based biodosimeter profiles blood biomarkers and uses ML to triage ionizing-radiation exposure-assessment at point-of-care.TagsAssayBioassayBiomarkerInventorsHelen TurnerIgor ShuryakKarthik KanagarajManagerJoan MartinezDepartmentsCenter for Radiological ResearchRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-05-05
Mouse line as a model for Peripheral T-cell Lymphoma with GATA3+ featuresCU23321Mouse model for Vav1-Myof1-driven Peripheral T-cell Lymphoma (GATA3+) enabling targeted therapy screening and pathogenesis study.TagsCD4CarcinogenesisGenetic testingInventorsAdolfo A. Ferrando M.D., Ph.D.Teresa Palomero VasquezManagerJoan MartinezDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-06-15CollectionsOncology
Automated 3D modeling of diseased livers using artificial intelligenceCU19417Automated, AI-guided 3D liver modeling from CT: segmenting heterogeneous diseased tissue for safer interventions.Tags3D modelingArthroscopyCT scanInventorsBinsheng ZhaoLarry SchwartzXiaotao GuoManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2020-06-12CollectionsOncologyDigital Health (Software, AI, bioinformatics, etc)
Inhibition of circadian regulation or mTOR complex increases immunity against bacterial infectionCU16116Inhibiting mTORC2 and adjusting circadian rhythm enhances immunity, offering host-targeted therapy against multidrug-resistant bacterial infections.TagsAntimicrobial resistanceApoptosisCancerInventorsJulie CanmanMatthew UlgheraitMichele M. Shirasu-HizaManagerKristin NeumanDepartmentsGenetics & DevelopmentPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2017-05-05
Functional hand orthosis for stroke patientsCU15275A lightweight, self-contained wearable hand orthosis using artificial tendons and motors to restore daily-hand movements for stroke patients.TagsLightweightMotor systemOrthoticsInventorsJoel Stein M.D.Matei CiocarlieManagerSara GusikDepartmentsMechanical EngineeringRehabilitation and Regenerative MedicineDivisionsCollege of Physicians and Surgeons (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2016-03-25
Modulation of mitochondrial transport for neuropathy treatmentCU24079Modulates MFN2-driven ATAT1 recruitment to restore tubulin acetylation and mitochondrial transport to treat CMT2A neuropathy.TagsAcetylationBiomarkerCharcot–Marie–Tooth diseaseInventorsAtul KumarFrancesca Bartolini Ph.D.ManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2024-08-29CollectionsCNS/Neurology
Characterizing and enhancing the efficacy of therapeutic CD8+ T cells2856Assay-driven enhancement and characterization of ex vivo CD8+ T cells to predict and boost therapeutic efficacy across cancers and infections.TagsAssayAutoimmune diseaseCognateInventorsJohn LoikePeter LeeRalph SteinmanManagerSara GusikDepartmentsBiomedical InformaticsMedicinePhysiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)HematologyRelease Date2018-08-29
Cysteine protease inhibitors to treat traumatic brain injury and Alzheimer's diseaseCU12222Potent, selective epoxide-based calpain-1 inhibitors ( NYC438/ NYC488 ) restore memory and synaptic function in AD and TBI models.TagsCysteine proteaseEnzyme inhibitorEpoxideInventorsGregory R.J. ThatcherIsaac SchieferMauro FaManagerJerry KokoshkaDepartmentsMedicinal Chemistry & PharmacognosyPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2019-04-29CollectionsSmall MoleculeCNS/Neurology
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancerCU15207Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.TagsAcute myeloid leukemiaAllotransplantationAntibodyInventorsGeorge Vlad Ph.D.Nicole Suciu-FocaZheng XuManagerSara GusikDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2023-03-08CollectionsOncology
Endotracheal intubation device with real-time haptic feedbackCU20147Smart laryngoscope with real-time, haptic feedback to improve endotracheal intubation accuracy, training, and patient safety.TagsIntubationLaryngoscopyPhysicianInventorsAmy Dee WuMary Grace GanaMiriam SaffernDepartmentsAnesthesiologyBiomedical EngineeringDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2019-11-04CollectionsMedical Device
Antibody for probing the guanine biosynthesis pathwayCU14353Monoclonal anti-IMPDH2 antibody labels and studies guanine biosynthesis, enabling cancer cell phenotyping and potential diagnostics/therapy.TagsAntibodyAntibody-drug conjugateBiosynthesisInventorsGeorge VladMuyang LiNicole Suciu-FocaManagerSara GusikDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2014-12-31
Targeting Delta-2 tubulin for the treatment of peripheral neuropathyCU25119Delta-2 tubulin as a therapeutic target to prevent or treat chemotherapy-induced peripheral neuropathy, addressing multiple drug classes.TagsAnalgesicAnticonvulsantAntidepressantInventorsFrancesca Bartolini Ph.D.Maria Elena PeroManagerKristin NeumanDepartmentsPathology & Cell BiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2025-12-17CollectionsCNS/Neurology
Antibody stimulates immune system against damaged cellsCU14352Antibody IA5 blocks ERp5, restores immune detection of damaged cells, enabling immunotherapy and diagnostics across ERp5‑overexpressing diseases.TagsAntibodyAntigenChronic lymphocytic leukemiaInventorsGeorge VladMuyang LiNicole Suciu-FocaManagerSara GusikDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2014-12-31
MicroRNAs that target Tau protein for the diagnosis and treatment of neurodegenerative diseaseCU12162MicroRNA panel targets Tau, enabling diagnosis and disease-modifying therapy for tauopathies, including tangle-predominant dementia.TagsAmyloid betaAutopsyBioassayInventorsJohn F. Crary M.D., Ph.D.ManagerKristin NeumanDepartmentsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Release Date2014-05-05
Antibody for targeting cancers characterized by increased iron uptakeCU14351TfR1-targeting antibody flags iron-uptake cancers, enabling detection and potential therapy by halting cancer cell division.TagsAntibodyBreast cancerCell growthInventorsGeorge VladMuyang LiNicole Suciu-FocaManagerSara GusikDepartmentsInstitute for Cancer GeneticsPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2014-12-31
GABAA receptor modulators for the treatment of bronchoconstrictive diseasesCU13064Subtype-selective GABAA modulators relax airway smooth muscle and reduce inflammation for safer, rapid bronchoconstriction therapy.TagsAsthmaCalcium channelChronic obstructive pulmonary diseaseInventorsCharles W. Emala M.D.George Gallos M.D.ManagerSara GusikDepartmentsAnesthesiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2017-05-18
CUMC Radiology Computational Image Analysis (CIA) Lab2906Advanced radiology software suite for automated, accurate lesion, organ, and tumor segmentation across CT/MRI datasets.TagsAbdomenAlgorithmBiomarkerInventorsBinsheng ZhaoLarry SchwartzXiaotao GuoManagerJoan MartinezDepartmentsRadiologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Release Date2013-12-02
