Divisions
College of Physicians and Surgeons (CUMC)
View all technologies
Conditional knockout mouse model for the Phf6 gene
CU22370
A tissue-specific Phf6 conditional knockout mouse model for studying Börjeson-Forssman-Lehmann syndrome and hematologic cancers.
Tags
Acute myeloid leukemia
Gene
High-throughput screening
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2022-08-20
Treatment for Alzheimer's Disease-related memory loss
CU13335
Selective PDE4D inhibitors improve AD memory with fewer side effects, offering low-dose, targeted cognitive benefits.
Tags
Amyloid beta
Brain
Cerebral cortex
Inventors
Ernesto Fedele
Jos Prickaerts
Mauro Fa
Manager
Jerry Kokoshka
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2018-05-11
Preclinical models of angioimmunoblastic T-cell lymphoma for therapeutic investigation
CU23322
RhoA G17V-driven mouse model of angioimmunoblastic T-cell lymphoma enables translational drug screening and pathogenesis study.
Tags
Cancer cell
Chemotherapy
Gene expression
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-06-15
Collections
Oncology
Non-invasive imaging analysis for predicting lung adenocarcinoma subtypes
CU20338
Noninvasive CT-based AI platform quantifying tumor imaging biomarkers to predict lung adenocarcinoma subtypes and prognosis.
Tags
Adenocarcinoma
Assay
Biomarker
Inventors
Binsheng Zhao
Larry Schwartz
Lin Lu
Manager
Joan Martinez
Departments
Radiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2020-10-15
Collections
Oncology
Platform/Research Tool
Delta-2 tubulin for detection and treatment of peripheral neuropathy
CU18162
Delta-2 tubulin biomarker enables CIPN diagnosis and targeted prevention/treatment, plus drug screening for prophylactic therapies.
Tags
Anticonvulsant
Biomarker
Chemotherapy
Inventors
Francesca Bartolini Ph.D.
Guido Cavaletti
Maria Elena Pero
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2019-07-15
Multiplexed T cell profiling for generating engineered regulatory T cell therapies
CU23310
High-throughput platform maps patient TCR–antigen pairs to create CRISPR‑engineered, autologous Tregs for precise local immune suppression.
Tags
Amyotrophic lateral sclerosis
Antigen
CRISPR
Inventors
Elizabeth M. Bradshaw
Neil Shneider
Ryan Hobson
Manager
Joan Martinez
Departments
Molecular Medicine
Neurology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2025-01-02
Video-guided bedside thoracoscopy system
CU24084
Video-guided bedside thoracoscopy enables safer, faster chest tube placement with real-time feedback and bedside diagnostics.
Tags
Biopsy
CT scan
Chest tube
Inventors
Josh Sonnet
Morgan Moroi
Robert Crum
Manager
Sara Gusik
Departments
Surgery
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2024-07-18
Adjustable repositioning of lung blocks for total body irradiation
CU21114
Adjustable lung-block holder enhances precise, multi-axis repositioning during total body irradiation, boosting efficiency and reducing lung exposure.
Tags
Lung
Inventors
Carl Elliston
David P. Horowitz
Gary W. Johnson
Manager
Jerry Kokoshka
Departments
Radiation Oncology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2020-12-13
Collections
Oncology
Panoramic cone beam computed tomography (CBCT) obtains full-scan CT images using only a half-scan rotation
2934
Half-scan panoramic CBCT reconstructs full volumetric images from 180-degree data, boosting efficiency, reducing dose, compatible with existing scanners.
Tags
Image stitching
Laser
Medical physics
Inventors
Jenghwa Chang
K.S. Clifford Chao
Lili Zhou
Manager
Orin Herskowitz
Departments
Radiation Oncology
Divisions
College of Physicians and Surgeons (CUMC)
Release Date
2013-09-03
Automated medical imaging method for optimized portal venous phase acquisition
CU18342
Automated CNN-based portal venous phase tuning improves tumor vascular density and volume assessment, enabling unbiased treatment response monitoring.
Tags
Algorithm
Angiogenesis
Aorta
Inventors
Binsheng Zhao
Jingchen Ma
Larry Schwartz
Manager
Joan Martinez
Departments
Radiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2019-10-17
Collections
Oncology
TLX1 mouse model recapitulates clinical symptoms of T cell acute lymphoblastic leukemia
CU23147
TLX1 transgenic mouse models human T-ALL, mirroring clinical progression to study pathogenesis, microenvironment, and drug responses.
Tags
Acute lymphoblastic leukemia
Aneuploidy
Aortic dissection
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-04-15
Collections
Oncology
Ferroptosis inducers as radiosensitizers for improved cancer treatment
CU19410
Ferroptosis-inducing radiosensitizers boost radiation therapy by non-apoptotic cancer cell death, overcoming resistance.
Tags
Apoptosis
DNA repair
Enzyme inducer
Inventors
Brent Stockwell
Ling Ye
Simon Cheng M.D., Ph.D.
Manager
Joan Martinez
Departments
Biological Sciences
Radiation Oncology
Divisions
College of Physicians and Surgeons (CUMC)
Faculty of the Arts & Sciences
Release Date
2022-08-05
Collections
Small Molecule
Oncology
A platform for development and validation of imaging biomarkers in oncology
CU20185
A scalable, open-platform for developing, validating, and applying quantitative imaging biomarkers to monitor tumor response across cancers.
Tags
Biomarker
Cancer immunotherapy
Drug development
Inventors
Binsheng Zhao
Hao Yang
Larry Schwartz
Manager
Joan Martinez
Departments
Radiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2020-03-03
Collections
Oncology
Platform/Research Tool
Functional hand orthosis for stroke patients
CU15139
A wearable, self-contained glove using motors and tendons restores dexterous hand movement for daily activities in stroke recovery.
Tags
Algorithm
Lightweight
Motor cortex
Inventors
Joel Stein M.D.
Matei Ciocarlie
Manager
Sara Gusik
Departments
Mechanical Engineering
Rehabilitation and Regenerative Medicine
Divisions
College of Physicians and Surgeons (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2019-04-08
Specialized diet for enhanced cancer treatment
CU21118
Amino acid-restricted diet enhances chemotherapy/radiation efficacy by selectively targeting cancer cells while maintaining energy needs.
Tags
Amino acid
Chemotherapy
Glioma
Inventors
Brent Stockwell
Dominique Higgins
Jeffrey Bruce
Manager
Jerry Kokoshka
Departments
Biological Sciences
Neurological Surgery
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2020-11-05
Collections
Oncology
Overcoming drug resistance in relapsed T-ALL patients
CU13051
Mutated NT5C2 inhibitors counteract nucleoside-analog resistance in relapsed T-ALL, enabling first-line therapies and broader applicability.
Tags
Acute lymphoblastic leukemia
Acute myeloid leukemia
Cancer cell
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Raul Rabadan
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Biomedical Informatics
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2013-09-03
Selective COX-2 radioligands for PET imaging of neuroinflammation
CU19254
Fluorine-18 COX-2 PET radioligands enable noninvasive imaging of neuroinflammation with higher affinity and broad clinical reach.
Tags
Agonist
COX-2 inhibitor
Celecoxib
Inventors
Akiva Mintz
J. John Mann
J.S. Dileep Kumar
Manager
Jerry Kokoshka
Departments
Psychiatry
Radiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2025-12-17
Rapid, point-of-care assessment of radiation exposure in human blood
CU24211
ELISA-based biodosimeter profiles blood biomarkers and uses ML to triage ionizing-radiation exposure-assessment at point-of-care.
Tags
Assay
Bioassay
Biomarker
Inventors
Helen Turner
Igor Shuryak
Karthik Kanagaraj
Manager
Joan Martinez
Departments
Center for Radiological Research
Radiation Oncology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2025-05-05
Mouse line as a model for Peripheral T-cell Lymphoma with GATA3+ features
CU23321
Mouse model for Vav1-Myof1-driven Peripheral T-cell Lymphoma (GATA3+) enabling targeted therapy screening and pathogenesis study.
Tags
CD4
Carcinogenesis
Genetic testing
Inventors
Adolfo A. Ferrando M.D., Ph.D.
Teresa Palomero Vasquez
Manager
Joan Martinez
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-06-15
Collections
Oncology
Automated 3D modeling of diseased livers using artificial intelligence
CU19417
Automated, AI-guided 3D liver modeling from CT: segmenting heterogeneous diseased tissue for safer interventions.
Tags
3D modeling
Arthroscopy
CT scan
Inventors
Binsheng Zhao
Larry Schwartz
Xiaotao Guo
Manager
Joan Martinez
Departments
Radiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2020-06-12
Collections
Oncology
Digital Health (Software, AI, bioinformatics, etc)
Inhibition of circadian regulation or mTOR complex increases immunity against bacterial infection
CU16116
Inhibiting mTORC2 and adjusting circadian rhythm enhances immunity, offering host-targeted therapy against multidrug-resistant bacterial infections.
Tags
Antimicrobial resistance
Apoptosis
Cancer
Inventors
Julie Canman
Matthew Ulgherait
Michele M. Shirasu-Hiza
Manager
Kristin Neuman
Departments
Genetics & Development
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2017-05-05
Functional hand orthosis for stroke patients
CU15275
A lightweight, self-contained wearable hand orthosis using artificial tendons and motors to restore daily-hand movements for stroke patients.
Tags
Lightweight
Motor system
Orthotics
Inventors
Joel Stein M.D.
Matei Ciocarlie
Manager
Sara Gusik
Departments
Mechanical Engineering
Rehabilitation and Regenerative Medicine
Divisions
College of Physicians and Surgeons (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2016-03-25
Modulation of mitochondrial transport for neuropathy treatment
CU24079
Modulates MFN2-driven ATAT1 recruitment to restore tubulin acetylation and mitochondrial transport to treat CMT2A neuropathy.
Tags
Acetylation
Biomarker
Charcot–Marie–Tooth disease
Inventors
Atul Kumar
Francesca Bartolini Ph.D.
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2024-08-29
Collections
CNS/Neurology
Characterizing and enhancing the efficacy of therapeutic CD8+ T cells
2856
Assay-driven enhancement and characterization of ex vivo CD8+ T cells to predict and boost therapeutic efficacy across cancers and infections.
Tags
Assay
Autoimmune disease
Cognate
Inventors
John Loike
Peter Lee
Ralph Steinman
Manager
Sara Gusik
Departments
Biomedical Informatics
Medicine
Physiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Hematology
Release Date
2018-08-29
Cysteine protease inhibitors to treat traumatic brain injury and Alzheimer's disease
CU12222
Potent, selective epoxide-based calpain-1 inhibitors ( NYC438/ NYC488 ) restore memory and synaptic function in AD and TBI models.
Tags
Cysteine protease
Enzyme inhibitor
Epoxide
Inventors
Gregory R.J. Thatcher
Isaac Schiefer
Mauro Fa
Manager
Jerry Kokoshka
Departments
Medicinal Chemistry & Pharmacognosy
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2019-04-29
Collections
Small Molecule
CNS/Neurology
Recombinant ILT3 protein-produced antibodies for immunotherapy treatment of cancer
CU15207
Engineered anti-ILT3 antibodies enable targeted cancer immunotherapy, modulating myeloid signals and enhancing immune blockade.
Tags
Acute myeloid leukemia
Allotransplantation
Antibody
Inventors
George Vlad Ph.D.
Nicole Suciu-Foca
Zheng Xu
Manager
Sara Gusik
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2023-03-08
Collections
Oncology
Endotracheal intubation device with real-time haptic feedback
CU20147
Smart laryngoscope with real-time, haptic feedback to improve endotracheal intubation accuracy, training, and patient safety.
Tags
Intubation
Laryngoscopy
Physician
Inventors
Amy Dee Wu
Mary Grace Gana
Miriam Saffern
Departments
Anesthesiology
Biomedical Engineering
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date
2019-11-04
Collections
Medical Device
Antibody for probing the guanine biosynthesis pathway
CU14353
Monoclonal anti-IMPDH2 antibody labels and studies guanine biosynthesis, enabling cancer cell phenotyping and potential diagnostics/therapy.
Tags
Antibody
Antibody-drug conjugate
Biosynthesis
Inventors
George Vlad
Muyang Li
Nicole Suciu-Foca
Manager
Sara Gusik
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2014-12-31
Targeting Delta-2 tubulin for the treatment of peripheral neuropathy
CU25119
Delta-2 tubulin as a therapeutic target to prevent or treat chemotherapy-induced peripheral neuropathy, addressing multiple drug classes.
Tags
Analgesic
Anticonvulsant
Antidepressant
Inventors
Francesca Bartolini Ph.D.
Maria Elena Pero
Manager
Kristin Neuman
Departments
Pathology & Cell Biology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2025-12-17
Collections
CNS/Neurology
Antibody stimulates immune system against damaged cells
CU14352
Antibody IA5 blocks ERp5, restores immune detection of damaged cells, enabling immunotherapy and diagnostics across ERp5‑overexpressing diseases.
Tags
Antibody
Antigen
Chronic lymphocytic leukemia
Inventors
George Vlad
Muyang Li
Nicole Suciu-Foca
Manager
Sara Gusik
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2014-12-31
MicroRNAs that target Tau protein for the diagnosis and treatment of neurodegenerative disease
CU12162
MicroRNA panel targets Tau, enabling diagnosis and disease-modifying therapy for tauopathies, including tangle-predominant dementia.
Tags
Amyloid beta
Autopsy
Bioassay
Inventors
John F. Crary M.D., Ph.D.
Manager
Kristin Neuman
Departments
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Release Date
2014-05-05
Antibody for targeting cancers characterized by increased iron uptake
CU14351
TfR1-targeting antibody flags iron-uptake cancers, enabling detection and potential therapy by halting cancer cell division.
Tags
Antibody
Breast cancer
Cell growth
Inventors
George Vlad
Muyang Li
Nicole Suciu-Foca
Manager
Sara Gusik
Departments
Institute for Cancer Genetics
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2014-12-31
GABAA receptor modulators for the treatment of bronchoconstrictive diseases
CU13064
Subtype-selective GABAA modulators relax airway smooth muscle and reduce inflammation for safer, rapid bronchoconstriction therapy.
Tags
Asthma
Calcium channel
Chronic obstructive pulmonary disease
Inventors
Charles W. Emala M.D.
George Gallos M.D.
Manager
Sara Gusik
Departments
Anesthesiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2017-05-18
CUMC Radiology Computational Image Analysis (CIA) Lab
2906
Advanced radiology software suite for automated, accurate lesion, organ, and tumor segmentation across CT/MRI datasets.
Tags
Abdomen
Algorithm
Biomarker
Inventors
Binsheng Zhao
Larry Schwartz
Xiaotao Guo
Manager
Joan Martinez
Departments
Radiology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date
2013-12-02
