Technologies
This technology is a mouse model expressing the human oncogene T cell leukemia homeobox protein-1 (TLX1), which mimics the genetic and molecular signatures of T cell acute lymphoblastic leukemia (T-ALL).
TLX1 has been known to have a central role in the development and progression of T cell acute lymphoblastic leukemia (T-ALL). However, a genetic and molecular dissection of pathogenesis onset and downstream targets of TLX1 have remained unknown. This is because T-ALL affects T lymphocytes and is characterized by invasion of these cells into other tissues and organs, eventually leading to tumor formation. This type of disease progression is difficult to replicate and study with cells in vitro.
This technology presents a transgenic mouse expressing the human TLX1 gene. The human TLX1 is located downstream of the mouse T cell–specific p56Lck proximal promoter. This mouse model recapitulates the development and timing of lymphoid tumors seen in humans diagnosed with T cell acute lymphoblastic leukemia (T-ALL). This mouse model allowed the identification of molecular interactors with TLX1, such as BCL11B, and of cooperating mutations in T-ALL pathogenesis onset. Overall, this mouse model replicates all known clinical signs of T-ALL in a living organism.
This technology has been validated in vivo.
IR CU23147
Licensing Contact: Joan Martinez