Virome-capture-sequencing (VirCapSeq) for viral infection diagnosisCU18221VirCapSeq-VERT: a high-throughput, cost-effective viral capture and sequencing platform enabling broad, sensitive vertebrate virus detection and discovery.TagsChain reactionDNA sequencingMassive parallel sequencingInventorsCheng GuoNischay MishraOrchid AllicockManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-09-04
Machine learning pipeline for neoantigen prioritization in personalized immunotherapiesCU25375ImmuneMirror: integrative ML pipeline predicting immunogenic neoantigens by combining processing, transport, binding, and recognition factors.TagsAntigenBiomarkerCancer immunotherapyInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Integrated AI platform for causal discovery and drug validationCU25378Cloud-based AI suite enabling causal discovery, multimodal data integration, and translational drug validation for personalized medicine.TagsAntigenArtificial intelligenceBias (statistics)InventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
An improved virome-capture-sequencing method for viral diagnosis and virus discoveryCU24096Improved virome capture sequencing boosts vertebrate virus detection with fewer probes, lower costs, and broader viral coverage.TagsAcidCerebrospinal fluidChemical libraryInventorsThomas BrieseW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2026-03-06
Penalized inverse-variance weighted estimator for robust Mendelian randomizationCU25374Penalized IVW estimator improves Mendelian randomization robustness to weak instruments and pleiotropy, with fast, bias-reducing correction.TagsBiomarkerBiometricsCausal inferenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Diagnostic peptides for Lyme disease serodiagnosisCU25107Rapid, affordable Lyme diagnostic using two specific peptides; enables early, at-home, point-of-care serodiagnosis with higher accuracy.TagsAntibioticAntibodyBorrelia burgdorferiInventorsRafal TokarzW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-04-04
A peptide microarray for serodiagnosis of exposure to high-threat hemorrhagic fever virusesCU23088Peptide microarray identifies immunoreactive epitopes for high-specificity serodiagnosis of hemorrhagic fevers, distinguishing infection from vaccination.TagsAntibodyBlood plasmaBlood transfusionInventorsLisa HensleyNischay MishraSunil Kumar DubeyManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2024-01-10CollectionsPlatform/Research Tool
CASE adherence index: A method for measuring adherence to antiretroviral therapyCU24088CASE Adherence Index: a 3-question, rapid ART adherence measure with strong virologic correlation for clinics and trials.TagsAdherence (medicine)Antiviral drugHIVInventorsSharon Mannheimer M.D.ManagerJerry KokoshkaDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2023-11-30
Diagnosis of viral disease in tilapia populationsCU15044Identifies TiLV-specific nucleic acid and protein markers for rapid, high-throughput tilapia viral diagnostics and monitoring.TagsDNA sequencingFish farmingHigh-throughput screeningInventorsNischay MishraSandra Abel NielsenThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2015-11-06
Genetic sequence database for identifying bacteria, pathogenicity, and antibiotic resistanceCU23199Curated million-sequence database enabling rapid bacterial ID, virulence and antibiotic-resistance detection for diagnostics.TagsAntimicrobial resistanceBiological databaseDrug developmentInventorsAmit RanjanCheng GuoThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-29
Novel algorithms for population structure inferenceCU25377ERStruct: fast, AI-augmented population structure inference from whole-genome data; scalable, MATLAB/Python package for precise PCA components.TagsAlgorithmAllele frequencyArtificial intelligenceInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
One step assay for rapid and selective diagnosis of arbovirusesCU16221Multiplex one-step qPCR quickly differentiates Zika, Dengue, Chikungunya, and West Nile from serum or urine samples.TagsArbovirusAssayChikungunyaInventorsNischay MishraRafal TokarzW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2017-08-18
Multi-knockoff filter for high-dimensional survival -omics with controlled false discovery rateCU25376CoxMKF: a multi-knockoff survival mediation method that guarantees finite-sample FDR control with stable, data-driven thresholds.TagsAssayBioinformaticsBiomarkerInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Deep learning framework for semiparametric causal mediation analysisCU25372DeepMed enables bias-reduced causal mediation with non-sparse deep nets, offering semiparametric guarantees and an open-source R package.TagsArtificial neural networkB testingBig dataInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-08-07
Platform to identify causal proteins in Alzheimer's for drug discoveryCU25371Integrated Mendelian-randomization and AlphaFold3 pipeline identifies causal Alzheimer's proteins to guide drug targets and diagnostics.TagsAssayCausalityDrug developmentInventorsZhonghua LiuManagerJoan MartinezDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2025-07-31
NeuroScore AI: an automated program for Alzheimer’s Disease risk scoringCU24217NeuroScore AI automates transcription and scoring of cognitive test audio to quantify Alzheimer's risk, speeding, unbiased.TagsCognitionInventorsAllison AielloManagerJoan MartinezDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2024-04-01CollectionsCNS/NeurologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
Non-invasive method for detection of cancer methylomesCU21185Non-invasive methylation profiling of tumor cfDNA enables early cancer detection, tumor origin, and targeted treatment insights.Tags5-MethylcytosineAntibodyAssayInventorsHui ZhouRegina Santella Ph.D.Zhiguo ZhangManagerJoan MartinezDepartmentsEnvironmental Health ScienceGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsMailman School Of Public Health (MSPH)Columbia University Medical Center (CUMC)Release Date2023-08-04CollectionsOncology
Assay for neurotransmitter leakage detection using fluorescent analoguesCU22294Real-time, non-radioactive fluorescent assay tracks vesicular neurotransmitter leakage in cells for high-throughput neurological research.TagsAssayHigh-throughput screeningIsotopic labelingInventorsGary MillerMeghan L. BucherManagerJoan MartinezDepartmentsEnvironmental Health ScienceDivisionsMailman School Of Public Health (MSPH)Release Date2023-09-08CollectionsCNS/NeurologyPlatform/Research Tool
Method for identifying vertebrate viruses using multiplexed, high-throughput genome sequencingCU16058Virome-Capture-Sequencing (VirCapSeq-VERT) enables high-throughput, cost-effective vertebrate virus detection and discovery.TagsChemical libraryGlobal healthUlcerative colitisInventorsAmit KapoorOmar JabadoThomas BrieseManagerKristin NeumanDepartmentsBiological SciencesEpidemiologyMailman School Of Public Health (MSPH)DivisionsMailman School Of Public Health (MSPH)Faculty of the Arts & SciencesRelease Date2025-09-04
Tagmentation-based method to improve global DNA methylation assaysCU23112A tagmentation-based, antibody-free MeDIP-seq method streamlines DNA methylation analysis with less input DNA and faster library prep.TagsAntibodyBlood plasmaChemical libraryInventorsHui ZhouHui-Chen WuRegina Santella Ph.D.ManagerJoan MartinezDepartmentsEnvironmental Health ScienceGenetics & DevelopmentInstitute for Cancer GeneticsDivisionsMailman School Of Public Health (MSPH)Columbia University Medical Center (CUMC)Release Date2023-08-15CollectionsOncology
Optimizing multiplex decisions using machine learning for cancer screeningCU23231Bayesian optimization reduces calculations for multiplex cancer screening without assumptions, updating predictions with real-world data.TagsAlgorithmBayesian inferenceBiomarkerInventorsYing Kuen (Ken) CheungManagerSara GusikDepartmentsBiostatisticsDivisionsMailman School Of Public Health (MSPH)Release Date2023-07-14CollectionsOncologyMedical DeviceDigital Health (Software, AI, bioinformatics, etc)
High-throughput assay for detection of Zika exposureCU17122High-throughput Zika serology using epitope signatures enables rapid, differential exposure detection, distinguishing past from acute infections.TagsAssayChikungunyaDifferential diagnosisInventorsAdrian CaciulaNischay MishraThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2018-02-15
Method of biomarker testing for autism spectrum disorder for early interventionCU23349Biomarker-based newborn metabolomic profiling enables early ASD risk identification and intervention, enhancing timely, personalized treatment.TagsApplied behavior analysisAutism spectrumBlood plasmaInventorsCamilla StoltenbergOliver FiehnW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsBiostatisticsEpidemiologyMolecular and Cellular BiologyDivisionsMailman School Of Public Health (MSPH)Technology Transfer ServicesRelease Date2024-02-15CollectionsCNS/NeurologyMedical Device
Rapid Molecular Differential Detection of SARS-CoV-2CU20260Rapid, multi-virus PCR assay enables differential, rapid detection of SARS-CoV-2, influenza A/B, improving diagnostic accuracy.TagsAssayBlood plasmaEpidemiologyInventorsNischay MishraSimon H. WilliamsThomas BrieseManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2022-08-20
Immunohistochemical test for determining the role of Aflatoxin B1 in liver cancer957Immunohistochemical AFB1-DNA adduct antibody links aflatoxin exposure to human liver cancer risk and research tools.TagsAntibodyAntigenCarcinogenInventorsI. Bernard Weinstein M.D.Ling Ling HsiehRegina SantellaManagerSara GusikDepartmentsAnesthesiologyMailman School Of Public Health (MSPH)MedicineDivisionsMailman School Of Public Health (MSPH)Columbia University Medical Center (CUMC)Release Date2016-04-07
Serochip for the diagnosis of tick-borne diseasesCU19325A programmable peptide microarray enables rapid, high-throughput, single-step serologic diagnosis of multiple tick-borne diseases.TagsAntibodyAssayEpidemiologyInventorsAdrian CaciulaNischay MishraRafal TokarzManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2025-09-04
Multiplexed serological platform for detection of SARS-CoV-2 exposureCU20309High-throughput microarray identifies SARS-CoV-2–specific epitopes, distinguishing them from other coronaviruses for precise serodiagnosis.TagsAntibodyCoronavirusEpitopeInventorsCheng GuoJiahai LuNischay MishraManagerKristin NeumanDepartmentsCenter for Infection and ImmunityEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2020-04-02CollectionsPlatform/Research Tool
Nanobodies for diagnosis, treatment and prevention of infection and disease caused by SARS-CoV-2 and variantsCU21304Broad-spectrum SARS-CoV-2 nanobodies enable diagnosis, treatment, and prevention across variants with easier delivery and stability.TagsAngiotensinAssayEnzymeInventorsThomas BrieseW. Ian Lipkin M.D.ManagerKristin NeumanDepartmentsEpidemiologyDivisionsMailman School Of Public Health (MSPH)Release Date2023-02-17CollectionsPlatform/Research Tool
Non-invasive quantification of nuclear brain imagesCU14274Non-invasive estimation of arterial input function using PET data and EHRs to quantify brain imaging without blood sampling.TagsBrainCT scanCatheterInventorsAndrew F. LaineArthur MikhnoFrancesca ZanderigoManagerJerry KokoshkaDepartmentsBiomedical EngineeringBiostatisticsPsychiatryDivisionsMailman School Of Public Health (MSPH)Columbia University Medical Center (CUMC)Fu Foundation School of Engineering and Applied Science (SEAS)Release Date2018-08-01
