Inventors
Brent Stockwell
View all technologies
Erastin analogs for genotype-selective ferroptosis induction
CU14068
ERS: Genotype-selective ferroptosis induction using enhanced erastin analogs targeting RAS V12+ tumors for potent, soluble, stable anticancer activity.
Tags
Apoptosis
Functional group
Genotype
Inventors
Brent Stockwell
Marie-Helene Larraufie
Wan Seok Yang
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2025-05-22
FIN56, a well-characterized small molecule for modeling ferroptosis-mediated cell death
CU17131
FIN56 triggers ferroptosis by GPX4 suppression and lipid oxidation, enabling research tools and drug discovery for neurodegenerative and cancer therapies.
Tags
Biosynthesis
Cancer
Cancer cell
Inventors
Brent Stockwell
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2018-05-25
Collections
Small Molecule
Oncology
CNS/Neurology
GPX4 inhibitors for cancer therapy
CU20261
Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.
Tags
Active site
Allosteric regulation
Apoptosis
Inventors
Brent Stockwell
Hengrui Liu
Manager
Joan Martinez
Departments
Biological Sciences
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2025-05-01
Dietary factors for the treatment of lymphoma
CU24111
Dietary iron and PUFA phospholipids induce ferroptosis to suppress DLBCL tumors, offering non-invasive, low-cost lymphoma therapy options.
Tags
Acyl group
Chemotherapy
Dietary supplement
Inventors
Brent Stockwell
Eman Riaz Ahmed
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2024-11-08
Lipid targets and biomarkers for ferroptosis
CU24174
Lipid biomarkers (PC-PUFA2s) drive ferroptosis; enables diagnostics and targeted therapies by regulating iron-dependent cell death.
Tags
Acyl group
Apoptosis
Biomarker
Inventors
Brent Stockwell
Baiyu Qiu
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2024-12-20
Small molecule inhibitors of ferroptosis for therapeutic applications
CU17132
Small-molecule ferroptosis inhibitors with improved drug-like properties for neurodegenerative, excitotoxic, and organ-protective therapies.
Tags
Cell death
Drug development
Epilepsy
Inventors
Brent Stockwell
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2020-07-09
Collections
Small Molecule
CNS/Neurology
Ferrostatins for therapeutic control of reactive oxygen species in excitotoxic and degenerative diseases
CU14077
Ferrostatin derivatives, notably SRS 15-72, inhibit ferroptosis, offering stable, soluble neuroprotective therapy for degeneration.
Tags
Amyotrophic lateral sclerosis
Antioxidant
Apoptosis
Inventors
Brent Stockwell
Rachid Skouta
Scott Dixon
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2015-08-24
Cancer treatment for Tumor Cells Using RSL3
M10-018
RAS-selective-lethal compound RSL3 induces rapid, nonapoptotic death in HRAS-mutant tumor cells; promising targeted cancer therapy.
Tags
Carcinogenesis
Drug discovery
Mutation
Inventors
Brent Stockwell
Rohitha SriRamaratnam
Manager
Joan Martinez
Departments
Biological Sciences
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2009-12-22
Ferroptosis inducers as radiosensitizers for improved cancer treatment
CU19410
Ferroptosis-inducing radiosensitizers boost radiation therapy by non-apoptotic cancer cell death, overcoming resistance.
Tags
Apoptosis
DNA repair
Enzyme inducer
Inventors
Brent Stockwell
Ling Ye
Simon Cheng M.D., Ph.D.
Manager
Joan Martinez
Departments
Biological Sciences
Radiation Oncology
Divisions
College of Physicians and Surgeons (CUMC)
Faculty of the Arts & Sciences
Release Date
2022-08-05
Collections
Small Molecule
Oncology
Lipid-peroxidation-resistant cell line for studying ferroptosis
CU20193
Engineered GPX4-overexpressing cells resist lipid peroxidation and ferroptosis, enabling high-throughput ferroptosis mechanism and drug screening.
Tags
Cancer
Drug development
Enzyme
Inventors
Brent Stockwell
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2020-07-21
Collections
Platform/Research Tool
Compounds for modulating ferroptosis and treating excitotoxic disorders
CU12192
Ferroptosis-inhibiting small molecules—novel therapy to prevent excitotoxic cell death in neurodegenerative diseases and cancer.
Tags
Apoptosis
Blood transfusion
Carcinogenesis
Inventors
Brent Stockwell
Rachid Skouta
Scott Dixon
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2016-01-06
Antibody for specific detection of ferroptosis
CU20038
Ferroptosis-specific antibody (3F3-FMA) detects ferroptotic cells via TfR1 for immunofluorescence, flow cytometry, and tissue assays.
Tags
Antibody
Apoptosis
Assay
Inventors
Brent Stockwell
Angie Huizhong Feng
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2019-08-07
Collections
CNS/Neurology
Small molecule therapeutics to treat treatment-resistant ALL and T-ALL
CU19220
NT5C2 inhibitors (e.g., HTP-2) boost chemotherapy efficacy in relapsed ALL/T-ALL, enabling combo treatments against resistance.
Tags
Acute lymphoblastic leukemia
Assay
Cancer cell
Inventors
Brent Stockwell
Adolfo A. Ferrando M.D., Ph.D.
Arie Zask
Manager
Joan Martinez
Departments
Biological Sciences
Institute for Cancer Genetics
Program in Cellular, Molecular, Structural and Genetic Studies
Divisions
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2021-02-03
Collections
Small Molecule
Oncology
Specialized diet for enhanced cancer treatment
CU21118
Amino acid-restricted diet enhances chemotherapy/radiation efficacy by selectively targeting cancer cells while maintaining energy needs.
Tags
Amino acid
Chemotherapy
Glioma
Inventors
Brent Stockwell
Dominique Higgins
Jeffrey Bruce
Manager
Jerry Kokoshka
Departments
Biological Sciences
Neurological Surgery
Pathology
Divisions
College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date
2020-11-05
Collections
Oncology
Discovery of RAS-selective drugs to treat cancer
M06-044
RAS-selective small molecules kill tumor cells with oncogenic RAS, enabling targeted, potent cancer therapies with reduced toxicity.
Tags
Carcinogenesis
Cytotoxicity
Drug resistance
Inventors
Brent Stockwell
Wan Seok Yang
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2005-12-06
Targeting oncogenic lipids for cancer therapy
CU20221
Targeting cancer's oncogenic lipids to disrupt rewired metabolism, aiming for higher therapeutic index and lower resistance risk.
Tags
Cancer
Metabolism
Inventors
Brent Stockwell
Manager
Joan Martinez
Departments
Biological Sciences
Divisions
Faculty of the Arts & Sciences
Release Date
2020-01-16
Collections
Oncology
Small-molecule drugs for targeted cancer therapy
M10-018-a
Small-molecule, RAS-selective cancer therapeutics inducing nonapoptotic death in RAS-driven tumors; improves precision, reduces toxicity.
Tags
Apoptosis
Carcinogenesis
Drug discovery
Inventors
Brent Stockwell
Rohitha SriRamaratnam
Wan Seok Yang
Manager
Joan Martinez
Departments
Biological Sciences
Chemistry
Divisions
Faculty of the Arts & Sciences
Release Date
2018-08-30
