Erastin analogs for genotype-selective ferroptosis inductionCU14068ERS: Genotype-selective ferroptosis induction using enhanced erastin analogs targeting RAS V12+ tumors for potent, soluble, stable anticancer activity.TagsApoptosisFunctional groupGenotypeInventorsBrent StockwellMarie-Helene LarraufieWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2025-05-22
FIN56, a well-characterized small molecule for modeling ferroptosis-mediated cell deathCU17131FIN56 triggers ferroptosis by GPX4 suppression and lipid oxidation, enabling research tools and drug discovery for neurodegenerative and cancer therapies.TagsBiosynthesisCancerCancer cellInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2018-05-25CollectionsSmall MoleculeOncologyCNS/Neurology
GPX4 inhibitors for cancer therapyCU20261Potent, selective GPX4 inhibitors induce ferroptosis to target EMT-driven, drug-resistant cancers and enable GPX4 research.TagsActive siteAllosteric regulationApoptosisInventorsBrent StockwellHengrui LiuManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2025-05-01
Dietary factors for the treatment of lymphomaCU24111Dietary iron and PUFA phospholipids induce ferroptosis to suppress DLBCL tumors, offering non-invasive, low-cost lymphoma therapy options.TagsAcyl groupChemotherapyDietary supplementInventorsBrent StockwellEman Riaz AhmedManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-11-08
Lipid targets and biomarkers for ferroptosisCU24174Lipid biomarkers (PC-PUFA2s) drive ferroptosis; enables diagnostics and targeted therapies by regulating iron-dependent cell death.TagsAcyl groupApoptosisBiomarkerInventorsBrent StockwellBaiyu QiuManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2024-12-20
Small molecule inhibitors of ferroptosis for therapeutic applicationsCU17132Small-molecule ferroptosis inhibitors with improved drug-like properties for neurodegenerative, excitotoxic, and organ-protective therapies.TagsCell deathDrug developmentEpilepsyInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-07-09CollectionsSmall MoleculeCNS/Neurology
Cancer treatment for Tumor Cells Using RSL3M10-018RAS-selective-lethal compound RSL3 induces rapid, nonapoptotic death in HRAS-mutant tumor cells; promising targeted cancer therapy.TagsCarcinogenesisDrug discoveryMutationInventorsBrent StockwellRohitha SriRamaratnamManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2009-12-22
Ferroptosis inducers as radiosensitizers for improved cancer treatmentCU19410Ferroptosis-inducing radiosensitizers boost radiation therapy by non-apoptotic cancer cell death, overcoming resistance.TagsApoptosisDNA repairEnzyme inducerInventorsBrent StockwellLing YeSimon Cheng M.D., Ph.D.ManagerJoan MartinezDepartmentsBiological SciencesRadiation OncologyDivisionsCollege of Physicians and Surgeons (CUMC)Faculty of the Arts & SciencesRelease Date2022-08-05CollectionsSmall MoleculeOncology
Lipid-peroxidation-resistant cell line for studying ferroptosisCU20193Engineered GPX4-overexpressing cells resist lipid peroxidation and ferroptosis, enabling high-throughput ferroptosis mechanism and drug screening.TagsCancerDrug developmentEnzymeInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-07-21CollectionsPlatform/Research Tool
Compounds for modulating ferroptosis and treating excitotoxic disordersCU12192Ferroptosis-inhibiting small molecules—novel therapy to prevent excitotoxic cell death in neurodegenerative diseases and cancer.TagsApoptosisBlood transfusionCarcinogenesisInventorsBrent StockwellRachid SkoutaScott DixonManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2016-01-06
Antibody for specific detection of ferroptosisCU20038Ferroptosis-specific antibody (3F3-FMA) detects ferroptotic cells via TfR1 for immunofluorescence, flow cytometry, and tissue assays.TagsAntibodyApoptosisAssayInventorsBrent StockwellAngie Huizhong FengManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2019-08-07CollectionsCNS/Neurology
Small molecule therapeutics to treat treatment-resistant ALL and T-ALLCU19220NT5C2 inhibitors (e.g., HTP-2) boost chemotherapy efficacy in relapsed ALL/T-ALL, enabling combo treatments against resistance.TagsAcute lymphoblastic leukemiaAssayCancer cellInventorsBrent StockwellAdolfo A. Ferrando M.D., Ph.D.Arie ZaskManagerJoan MartinezDepartmentsBiological SciencesInstitute for Cancer GeneticsProgram in Cellular, Molecular, Structural and Genetic StudiesDivisionsColumbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2021-02-03CollectionsSmall MoleculeOncology
Specialized diet for enhanced cancer treatmentCU21118Amino acid-restricted diet enhances chemotherapy/radiation efficacy by selectively targeting cancer cells while maintaining energy needs.TagsAmino acidChemotherapyGliomaInventorsBrent StockwellDominique HigginsJeffrey BruceManagerJerry KokoshkaDepartmentsBiological SciencesNeurological SurgeryPathologyDivisionsCollege of Physicians and Surgeons (CUMC)Columbia University Medical Center (CUMC)Faculty of the Arts & SciencesRelease Date2020-11-05CollectionsOncology
Discovery of RAS-selective drugs to treat cancerM06-044RAS-selective small molecules kill tumor cells with oncogenic RAS, enabling targeted, potent cancer therapies with reduced toxicity.TagsCarcinogenesisCytotoxicityDrug resistanceInventorsBrent StockwellWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2005-12-06
Targeting oncogenic lipids for cancer therapyCU20221Targeting cancer's oncogenic lipids to disrupt rewired metabolism, aiming for higher therapeutic index and lower resistance risk.TagsCancerMetabolismInventorsBrent StockwellManagerJoan MartinezDepartmentsBiological SciencesDivisionsFaculty of the Arts & SciencesRelease Date2020-01-16CollectionsOncology
Small-molecule drugs for targeted cancer therapyM10-018-aSmall-molecule, RAS-selective cancer therapeutics inducing nonapoptotic death in RAS-driven tumors; improves precision, reduces toxicity.TagsApoptosisCarcinogenesisDrug discoveryInventorsBrent StockwellRohitha SriRamaratnamWan Seok YangManagerJoan MartinezDepartmentsBiological SciencesChemistryDivisionsFaculty of the Arts & SciencesRelease Date2018-08-30
