Manager

Jerry Kokoshka

142 results

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Safer ibogaine analogs for the treatment of substance use disorders

CU24362

Safer oxa-ibogaine analogs reduce cardiac risk while retaining ibogaine’s anti-addiction effects and therapeutic potential.

Tags: Alkaloid
Analgesic
Arrhythmia
Inventors: Dalibor Sames
David Lankri
Vaclav Havel
Manager: Jerry Kokoshka
Departments: Chemistry
Divisions: Faculty of the Arts & Sciences
Release Date: 2025-03-12
Collections: CNS/Neurology

Digital addiction monitoring and early mental health intervention platform

CU26164

Passive, trajectory-based digital addiction monitoring with adaptive mental-health interventions to preempt crises and escalate care.

Tags: Cohort study
Major depressive disorder
Mental health
Inventors: J. John Mann
Yunyu Xiao
Manager: Jerry Kokoshka
Departments: Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2026-02-17

NAPA-ID: a proximity-based system to decode protein-protein interactions

CU26166

NAPA-ID enables antibody-guided, proximity labeling of protein interactions without genetic editing, compatible with standard proteomics workflows.

Tags: Antibody
Biological engineering
Biomarker
Inventors: Jeremy Cartalas
Sara Zaccara
Manager: Jerry Kokoshka
Departments: Systems Biology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2026-02-17

Biofluid preparation method for chemical analysis

CU26156

Three-component chromatography column enables rapid, affordable biofluid cleanup for mass spectrometry, boosting throughput and automation.

Tags: Body fluid
Chromatography
Food safety
Inventors: Mazdak M. Bradberry
Manager: Jerry Kokoshka
Departments: Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2026-02-17

SUMO2 conjugation therapy for restoring cognitive function in Alzheimer's disease

CU23265

SUMO2-based biologic restores synaptic function and memory in Alzheimer's without reducing amyloid, enabling late-stage cognitive recovery.

Tags: Adjuvant therapy
Amyloid beta
Blood–brain barrier
Inventors: Luana Fioriti Ph.D.
Ottavio Arancio
Paul Edward Fraser
Manager: Jerry Kokoshka
Departments: Mortimer B. Zuckerman Mind Brain Behavior Institute
Pathology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-06-26

Machine-learning algorithm to improve disease diagnosis using magnetic resonance spectroscopy

CU24256

A deep learning system automates and speeds up in vivo metabolite quantification from MRS, improving disease diagnosis with telecoms-ready MRI integration.

Tags: Algorithm
Deep learning
Dementia
Inventors: Christopher Wu
Jia Guo
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Biomedical Engineering
Neurology
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2025-05-30

Method for studying in-cell single-molecule FRET data collected from proteins diffusing at membrane surfaces using wide-field imaging

CU15268

In-cell smFRET tracking links membrane diffusion states with real-time structural dynamics using wide-field imaging and integrated analysis.

Tags: Biophysics
Cell membrane
Confocal microscopy
Inventors: Jonathan Javitch
Khuloud Jaqaman
Peter Geggier
Manager: Jerry Kokoshka
Departments: Biophysics
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-03-05
Collections: Platform/Research Tool

Probiotics for Fusobacterium-related disease

CU24121

Engineered probiotics produce E-cadherin peptides to block Fn attachment, lowering Fusobacterium virulence and colonization.

Tags: Antibiotic
Bacteria
Biofilm
Inventors: Carlotta Ronda
Yiping Han
Manager: Jerry Kokoshka
Departments: Periodontics
Systems Biology
Divisions: Columbia University Medical Campus (CUMC)
Release Date: 2023-12-18
Collections: Small Molecule
CNS/Neurology
Women's Health

CASE adherence index: A method for measuring adherence to antiretroviral therapy

CU24088

CASE Adherence Index: a 3-question, rapid ART adherence measure with strong virologic correlation for clinics and trials.

Tags: Adherence (medicine)
Antiviral drug
HIV
Inventors: Sharon Mannheimer M.D.
Manager: Jerry Kokoshka
Departments: Epidemiology
Divisions: Mailman School Of Public Health (MSPH)
Release Date: 2023-11-30

Felducials: Non-invasive fiducial markers for robotic neurosurgery and neuroimaging precision

CU22359

Non-invasive fiducial markers attach to head holders, boosting sub-mm precision for robotic neurosurgery and frame-based CT navigation.

Tags: CT scan
Facial recognition system
Neuroimaging
Inventors: Guy McKhann
Neil A. Feldstein
Manager: Jerry Kokoshka
Departments: Neurological Surgery
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2022-08-20
Collections: CNS/Neurology
Medical Device
Digital Health (Software, AI, bioinformatics, etc)

Synthetic, modular polypeptide system for targeted cell therapy strategies

CU18022

Synthetic, modular chimeric polypeptides reprogram endogenous signaling (Notch-based) for versatile, tunable cell therapies and research.

Tags: Cell signaling
Cell surface receptor
Cell therapy
Inventors: Gary Struhl
Paul Langridge
Manager: Jerry Kokoshka
Departments: Genetics & Development
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2020-11-19

Fluorescent substrates for imaging neurotransmission

M06-109-a

Fluorescent false neurotransmitters visualize dopamine vesicle content and release at single-synapse resolution for imaging and drug discovery.

Tags: Assay
Attention deficit hyperactivity disorder
Bipolar disorder
Inventors: Dalibor Sames
David Sulzer Ph.D.
Niko Gubernator
Manager: Jerry Kokoshka
Departments: Chemistry
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date: 2018-11-13

Predicting breast cancer treatment response through PIK3R1 mutation profiling

CU26021

Predicts breast cancer drug response via endogenous kinase inhibition models using PIK3R1 mutations; rapid, high-throughput screening.

Tags: AKT1
Adenine
Breast cancer
Inventors: Neil Vasan MD, PhD
Manager: Jerry Kokoshka
Release Date: 2025-10-09

Hormone therapy for age-related frailty and muscle degeneration

CU15011

Osteocalcin-based hormone therapy aims to reverse age-related frailty, muscle loss, and linked metabolic, reproductive, and cognitive disorders.

Tags: Anxiety
Apoptosis
Asthma
Inventors: Gerard Karsenty M.D., Ph.D.
Paula Mera
Manager: Jerry Kokoshka
Departments: Genetics & Development
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-08-29

VPS35 floxed mouse model for Alzheimer's drug discovery

CU25395

Inducible, tissue-specific VPS35 knockout mouse enabling controlled adult-onset retromer disruption for Alzheimer’s research.

Tags: Biomarker
Cerebrospinal fluid
Drug discovery
Inventors: Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-07-31

Wearable device for automated nutrition monitoring

CU25198

A non-invasive wearable using machine learning to auto-monitor dietary intake and biometric data for real-time nutrition tracking.

Tags: Activity tracker
Biometrics
Cardiovascular disease
Inventors: Alexander Goldberg
Weihao Xu
Manager: Jerry Kokoshka
Departments: Biomedical Engineering
Medicine
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2025-04-08

Monoallelic expression detection for improved monogenic disorder risk assessment

CU25133

Monoallelic expression detection improves monogenic disorder risk assessment by incorporating biased allele expression and incomplete penetrance.

Tags: Allele
Autosome
Gene therapy
Inventors: Dusan Bogunovic
Manager: Jerry Kokoshka
Departments: Pediatrics
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-03-21

CRISPR deletion of endogenous T cell receptor chains for optimized immunotherapies

CU20245

CRISPR deletes endogenous TCR chains while preserving transgenic TCRs, enabling safer, off-the-shelf CAR-T/TCR therapies.

Tags: Cancer
Chimeric antigen receptor T cell
Graft-versus-host disease
Inventors: Megan Sykes M.D.
Mohsen Khosravi Maharlooei
Remi Creusot
Manager: Jerry Kokoshka
Departments: Medicine
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-01-30

Orally administered drug with extended release for obesity treatment

CU23375

Oral, extended-release nanoparticle drug LIGNOCAL delivers lipocalin-2 to suppress appetite, boost metabolism, and aid obesity/diabetes treatment.

Tags: Anorectic
Bioavailability
Biological half-life
Inventors: Jessica DeAngelis
Kam Leong
Stavroula Kousteni
Manager: Jerry Kokoshka
Departments: Biomedical Engineering
Herbert and Florence Irving Center for Clinical Research
Physiology and Cellular Biophysics
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2024-11-26

Mouse model for studying CA2 region in the hippocampus

CU23371

Transgenic Amigo2-Cre mouse model enables CA2-specific studies of social memory and hippocampal projections for preclinical research.

Tags: CREB
Cre recombinase
Drug discovery
Inventors: Chyuan-Sheng (Victor) Lin
Frederick Luke Hitti
Steven A. Siegelbaum PhD
Manager: Jerry Kokoshka
Departments: Neurology
Opthamology
Pharmacology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-09-08
Collections: CNS/Neurology

Treatment for Alzheimer's Disease-related memory loss

CU13335

Selective PDE4D inhibitors improve AD memory with fewer side effects, offering low-dose, targeted cognitive benefits.

Tags: Amyloid beta
Brain
Cerebral cortex
Inventors: Ernesto Fedele
Jos Prickaerts
Mauro Fa
Manager: Jerry Kokoshka
Departments: Pathology
Divisions: College of Physicians and Surgeons (CUMC)
Columbia University Medical Center (CUMC)
Release Date: 2018-05-11

Targeting the formation of aggressive cancer-associated fibroblasts for metastasis inhibition in solid tumors

CU21079

Computationally maps adipose-derived cells transforming into COL11A1+ aCAFs to block metastasis across solid tumors.

Tags: Adipocyte
Adipose tissue
Cancer immunotherapy
Inventors: Dimitris Anastassiou
Kaiyi Zhu
Lingyi Cai
Manager: Jerry Kokoshka
Departments: Electrical Engineering
Divisions: Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2020-09-23
Collections: Oncology

Engineered cell line for inducible protein expression for single-molecule imaging

CU24352

Inducible CHO cell line enables single-molecule GPCR interaction tracking in live cells with high-resolution smFRET.

Tags: Cell membrane
Cell signaling
Cell surface receptor
Inventors: Jonathan Javitch
Wesley Asher
Manager: Jerry Kokoshka
Departments: Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-07-05

Psychedelic based treatment for Parkinson’s disease and other psychiatric disorders

CU23079

Non-hallucinogenic 5-HT2A agonist Ariadne targets Parkinson’s and psychiatric disorders, offering safer, broader therapeutic potential.

Tags: 5-HT2A receptor
Agonist
Bipolar disorder
Inventors: Dalibor Sames
Michael J. Cunningham
Manager: Jerry Kokoshka
Departments: Chemistry
Divisions: Faculty of the Arts & Sciences
Release Date: 2023-11-03
Collections: Small Molecule
CNS/Neurology

Cell-type specific covalent modifications of proteins in vivo

CU22274

Cell-type specific in vivo covalent linking of SpyTag/SpyCatcher proteins enables targeted tagging, visualization, and functional protein studies.

Tags: Antibody
Antigen
Assay
Inventors: Richard S. Mann
Siqian Feng
Manager: Jerry Kokoshka
Departments: Biochemistry & Molecular Biophysics
Biochemistry & Molecular Biophysics, Zuckerman Institute
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2022-06-19
Collections: Platform/Research Tool

Immature myeloid cell activation pathway in inflammation-linked cancer

CU26121

IL-8–driven immature myeloid cell mobilization fuels inflammation-linked GI cancer; targets IMCs for therapy and biomarkers.

Tags: Angiogenesis
Biomarker
Bone marrow
Inventors: Timothy Wang M.D.
Manager: Jerry Kokoshka
Departments: Herbert and Florence Irving Center for Clinical Research
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2026-01-08

Exogenous Rac1 analogs to treat acute lung injury

CU23206

Exogenous activated Rac1 (V12Rac1) protects lungs from ALI/ARDS by stabilizing actin and blocking proinflammatory signaling.

Tags: Actin
Acute respiratory distress syndrome
Epithelium
Inventors: Francine Katz
Galina Gusarova
Jahar Bhattacharya
Manager: Jerry Kokoshka
Departments: Medicine
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-11-26

Generation of self-renewed CD4+ T cells for cancer and viral disease immunotherapy

CU24385

Ex vivo culture method yields durable, polyfunctional cytotoxic CD4+ T cells for enhanced cancer and viral immunotherapies.

Tags: Antigen
Cell culture
Cell therapy
Inventors: Mithil Soni
Pawel Muranski
Prabesh Khatiwada
Manager: Jerry Kokoshka
Departments: Columbia Center for Translational Immunology
Medicine
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-09-16

Combined small molecule treatment as a synergistic epigenetic therapy for pancreatic cancer

CU23218

Combined HDAC and eIF4A inhibition reprograms pancreatic cancer epigenetically, boosting efficacy and tumor suppression in vivo.

Tags: Adenocarcinoma
Apoptosis
Chemotherapy
Inventors: Antonio Fojo
Maryam Safari
Susan Bates
Manager: Jerry Kokoshka
Departments: Medicine
Oncology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-08-22

Restoration of retromer complex in neurodegenerative diseases via transcriptional regulator

CU18398

Target CREB3L2-ATF4 complex to restore retromer function, slowing neurodegenerative progression in AD/PD.

Tags: Drug development
Endosome
Gene
Inventors: Claudio Andre Gouveia Martins Roque
Jimena Baleriola
Ulrich Hengst
Manager: Jerry Kokoshka
Departments: Pathology
Taub Institute
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-03-03
Collections: Small Molecule
CNS/Neurology

Treatment and prevention of intestinal graft-versus-host disease following HPSC transplantation

CU19098

GLP-2 analogs strengthen intestinal barriers to prevent/treat GVHD after allogeneic stem cell transplantation, with low toxicity.

Tags: Allotransplantation
Autoimmune disease
Chemotherapy
Inventors: Ran Reshef
Manager: Jerry Kokoshka
Departments: Oncology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2020-12-10

Fluorescent labeling of cell surface proteins in vivo with spatiotemporal control

CU25172

Fluorescently label cell-surface proteins in vivo using DogTag-DogCatcher for spatiotemporal, loop-targeted GFP tagging.

Tags: Biopsy
Cell membrane
Covalent bond
Inventors: Kevin Rostam
Richard S. Mann
Manager: Jerry Kokoshka
Departments: Biochemistry & Molecular Biophysics
Biological Sciences
Divisions: Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date: 2025-03-21

Metabolic biomarkers for targeted treatment of schizophrenia and related disorders

CU25032

Metabolic biomarkers identify GLS1-driven glutamate elevation in early schizophrenia via 3T 1H-MRS, enabling targeted therapies and trials.

Tags: Atrophy
Attention deficit hyperactivity disorder
Biomarker
Inventors: Douglas Rothman
Jia Guo
Scott A. Small M.D.
Manager: Jerry Kokoshka
Departments: Neurology
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-12-06

Ring attachment for heart valve surgery

CU19219

A flexible, suturing-free heart valve ring attachment that converts incomplete rings to complete, enhancing mitral/tricuspid repair.

Tags: Heart valve
Ion implantation
Mitral regurgitation
Inventors: Shalaka Vinayak Bapat
Vinayak N. Bapat
Manager: Jerry Kokoshka
Departments: Surgery
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-05-27

Noise-reducing MR image reconstruction software

CU23246

AI-based MRI denoising and reconstruction using AFT-Net enables faster, clearer preclinical scans with fewer contrast requirements.

Tags: Blood–brain barrier
Deep learning
Fourier transform
Inventors: Jia Guo
Yanting Yang
Manager: Jerry Kokoshka
Departments: Biomedical Engineering
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Fu Foundation School of Engineering and Applied Science (SEAS)
Release Date: 2023-07-01
Collections: Digital Health (Software, AI, bioinformatics, etc)

Targeted immunotherapy for amyloid fibril removal

Proxy61

Targeted antibody therapy mobilizes the immune system to specifically remove disease-associated amyloid fibrils.

Tags: Amyloid
Amyloidosis
Cell-mediated immunity
Inventors: Alan Solomon
Jonathan Stuart Wall
Rudi Hrncic
Manager: Jerry Kokoshka
Departments: Oncology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2018-04-20

Conformational DNA aptamers enabling small-molecule lateral flow assays

CU26117

Conformational DNA aptamers enable rapid, cost-effective small-molecule detection in lateral flow assays via structure-switching binding.

Tags: Analyte
Antibody
Aptamer
Inventors: Kyungae Yang
Manager: Jerry Kokoshka
Departments: Medicine
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-12-01

Combinatorial treatment for amyotrophic lateral sclerosis (ALS)

CU25447

Combinatorial ASO therapy targets 15 dysregulated genes in SOD1-ALS, mitigating neuron death and boosting motor function.

Tags: Amyotrophic lateral sclerosis
Biomarker
Combinatorics
Inventors: George Z. Mentis Ph.D.
JoonHyung Park
Manager: Jerry Kokoshka
Departments: Pathology & Cell Biology
Pathology and Cell Biology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2025-07-29

Cell therapy methods for improved transplant acceptance

CU22264

Hematopoietic stem cell therapy induces immune tolerance to transplanted organs, reducing rejection and long-term immunosuppression needs.

Tags: Allotransplantation
CD34
Cell therapy
Inventors: Aubrey Marie Sherry
Brian H. Johnstone
Dongsheng Gu
Manager: Jerry Kokoshka
Departments: Medicine
Surgery
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-09-05

Transcriptional reprogramming platform for neuroprotection, rejuvenation, and treatment of motor neuron diseases

CU23208

AAV-delivered Islet1/Lhx3 re-expression reprograms motor neurons, restoring youthful resilience to prevent motor neuron degeneration.

Tags: Amyotrophic lateral sclerosis
Gene expression
Gene therapy
Inventors: Emily Rhodes Lowry
Hynek Wichterle
Tulsi Patel
Manager: Jerry Kokoshka
Departments: Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2024-01-18
Collections: Gene Therapy

Mouse model for ion channel disruption via TRIP8b disruption

CU23232

Inducible mouse model to disrupt TRIP8b, altering HCN ion channel localization in heart/brain cells for in vivo study and drug screening.

Tags: Dendrite
Exon
Gene expression
Inventors: Bina Santoro
Steven A. Siegelbaum PhD
Manager: Jerry Kokoshka
Departments: CENTER OF NEUROBIOLOGY AND BEHAVIOR
Pharmacology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-05-02
Collections: CNS/Neurology
Platform/Research Tool
Cardiovascular

Immunosuppressant for treating inflammatory and autoimmune diseases

CU21025

A novel immunosuppressant blocks T cell expansion to treat organ transplant rejection and autoimmune/inflammatory diseases.

Tags: Enzyme
Immunosuppressive drug
Inflammation
Inventors: Huihui Ma
Jing Fu Ph.D.
Markus Mapara
Manager: Jerry Kokoshka
Departments: Medicine
Oncology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-03-23
Collections: Small Molecule

Mouse model to study prelamin A in aging

CU22366

A knock-in mouse model producing only prelamin A with near-normal lifespan to study long-term effects of farnesylated prelamin A.

Tags: Adipose tissue
Enzyme
Fibroblast
Inventors: Howard Worman
Yuexia Wang
Manager: Jerry Kokoshka
Departments: Medicine
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2022-08-20

Raman-tagged aptamer sensor for ultra-stable, multiplexed biomolecule detection

CU25105

Ultra-stable Raman-tagged aptamer sensor enables multiplexed, environment-insensitive biomolecule detection via structure-switching aptamers.

Tags: Aptamer
Biomolecule
Conformational change
Inventors: Achut Silwal
Milan N. Stojanovic M.D.
Manager: Jerry Kokoshka
Departments: Medicine
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2026-02-20

Small molecule inhibitor of cognitive impairment associated with neurodegenerative disease

CU23096

Small molecule minaprine analog targets 5-HT2B to curb cognitive/behavioral deficits in neurodegenerative diseases, including Alzheimer's.

Tags: 5-HT receptor
5-HT2B receptor
Amyloid beta
Inventors: Daniel M. Watterson
Erica Acquarone
Ottavio Arancio
Manager: Jerry Kokoshka
Departments: Pathology
Pharmacology
Taub Institute
Divisions: Columbia University Medical Center (CUMC)
Feinberg School of Medicine
Release Date: 2025-04-10

Antibody therapeutic targeting Funsobacterium nucleatum-mediated diseases

CU21261

Monoclonal antibody against Annexin A1 blocks Fusobacterium nucleatum invasion, offering targeted prevention and treatment of Fn-related cancers.

Tags: Antibiotic
Antibody
Bacteria
Inventors: Yiping Han
Manager: Jerry Kokoshka
Departments: Periodontics
Divisions: Columbia University Medical Campus (CUMC)
Release Date: 2024-02-09
Collections: Rare Disease
Oncology

Engineered anti-Cre antibody for detection of Cre

CU23045

Engineered monoclonal anti-Cre antibody enables precise, tissue-specific Cre detection, improving reliability over current reagents.

Tags: Antibody
Cre recombinase
DNA sequencing
Inventors: David Ng
Susan Brenner-Morton
Manager: Jerry Kokoshka
Departments: Biochemistry
Mortimer B. Zuckerman Mind Brain Behavior Institute
Release Date: 2022-10-31

Fluorescent substrates for imaging neurotransmission

M06-109

Fluorescent false neurotransmitters enable high-resolution, single-synapse imaging of monoamine release and VMAT2 activity.

Tags: Assay
Attention deficit hyperactivity disorder
Bipolar disorder
Inventors: Dalibor Sames
David Sulzer Ph.D.
Niko Gubernator
Manager: Jerry Kokoshka
Departments: Chemistry
Psychiatry
Divisions: Columbia University Medical Center (CUMC)
Faculty of the Arts & Sciences
Release Date: 2006-06-15

Modulating inflammation by altering 3’ Untranslated Region (3’ UTR) length

CU23300

Modulates inflammation by lengthening 3’ UTRs to control immunogenic dsRNA, enabling tunable neuroinflammation therapies and cancer immunotherapy.

Tags: Cancer immunotherapy
Homeostasis
Immunogenicity
Inventors: Hachung Chung
Heegwon Shin
Tyler Dorrity
Manager: Jerry Kokoshka
Departments: Microbiology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-07-01
Collections: Oncology
CNS/Neurology

A spinal motor neuron-specific enhancer for cell-type specific gene expression control in the developing and adult central nervous system

CU22281

Spinal motor neuron–specific enhancer enables AAV-deliverable, cell-type–restricted gene overexpression/knockdown in adults and development.

Tags: Central nervous system
Cholinergic
Gene expression
Inventors: Hynek Wichterle
Tulsi Patel
Manager: Jerry Kokoshka
Departments: Center for Neurobiology & Behavior
Pathology & Cell Biology
Divisions: Columbia University Medical Center (CUMC)
Release Date: 2023-05-02
Collections: Gene Therapy
CNS/Neurology