This technology is an inducible mouse model designed to study the role of Aldh3a1 in pancreatic β-cells cells.
The Aldehyde dehydrogenase family 3 subfamily A1 (Aldh3a1) gene is expressed in the pancreas, where it detoxifies aldehydes generated during metabolic processes. Current methods to study Aldh3a1's role in supporting pancreatic function and overall cellular health are limited by the labeling techniques used to identify Aldh3a1-positive cells.
This technology is a mouse line that harbors a tamoxifen-activable Cre (Creert) knocked into the aldehyde dehydrogenase family 1 subfamily A3 (Aldh1a3) gene. This line enables tamoxifen-inducible Cre recombinase activity in cells expressing Aldh1a3. This mouse line is useful for lineage tracing and studying the role of Aldh1a3 in dedifferentiating pancreatic β-cells. This tool has the potential to provide valuable insights into pancreatic health and disease, including diabetes, pancreatitis, and pancreatic cancer, overcoming previous limitations in tracing Aldh1a3-positive cells.
IR CU25020
Licensing Contact: Cynthia Lang