Antisera to Myocyte Enhancer Factor 2 (MEF2) Proteins

Lead Inventor: Ronald Michael Prywes, PhD Myocyte Enhancer Factor 2 (MEF2) Transcriptional Regulatory Proteins have Key Roles in Cardiac and Skeletal Muscle Development The MEF2 family of transcription factors is highly expressed in the brain when neurons undergo dendritic maturation and synapse formation. MEF2A is especially abundant in granule neurons of the cerebellar cortex throughout the period of synaptogenesis. MEF2A has key roles in cardiac and skeletal muscle development. Myocyte enhancer factor 2 (MEF2) transcriptional regulatory proteins are also key regulators of muscle-specific gene expression and also play a general role in the cellular response to growth factors, cytokines and environmental stressors. MEF2B are MADS-box transcription factors that are thought to regulate expression of many muscle related genes during development. They are also thought to be involved in differentiation of certain neurogenic cells. MEF2D is thought to be involved in the differentiation of myogenic and also some neurogenic cells. It is the only member of the MEF2 family that is present in undifferentiated myoblasts, suggesting that it may play a role in the very early stages of myogenic development. MEF2D has also been implicated in T cell apoptosis and lymphoblastic leukaemia. This is rabbit antisera to MEF2 proteins. Polyclonal Sera Detects Human and Murine Forms of MEF2 • Antigen: myocyte enhancer factor 2A (MEF2A) recombinant protein fragment (amino acids 272-491), recombinant protein corresponding to amino acids 243-365 of human MEF2B (myocyte enhancer factor 2), recombinant protein corresponding to amino acids 292-514 of mouse MEF2D (myocyte enhancer factor 2D) • Antibody type: rabbit polyclonal Applications: • This polyclonal sera detects both human and murine forms of MEF2 and has been tested for EMSA, IP, and WB applications. Advantages: • Highly specific and immunohistochemistry- and immunoprecipitation-competent sera that can be used for accuracy. Patent Status: Copyright Licensing Status: Copyright / Material available for Express Licensing MEF2A antibody MEF2B antibody MEF2D antibody Publications: Post-translational control of the MEF2A transcriptional regulatory protein.Ornatsky, OI et al. (1999) NAR. 27(13):2646-54. Regulatory role of MEF2D in serum induction of the c-jun promoter. Han, TH and Prywes, R. (1995). MCB. 15(6):2907-15.