This technology is a highly adjustable biventricular pacemaker that can be used perioperatively or postoperatively and can be customized based on individual response.
Unmet Need: Optimized biventricular pacing for personalized cardiac resynchronization therapy and perioperative pacing
Biventricular pacing (BiVP) can improve cardiac function in patients after open-heart surgery in heart failure. Cardiac resynchronization therapy greatly reduces mortality, shortens hospital stays, and improves recovery and quality of life post-surgery. There has been limited formal optimization performed to maximize BiVP efficiency and efficacy across a variety of settings, including temporary pacing after cardiac surgery.
The Technology: Biventricular pacemaker with multiparameter controls and objective data recording
This biventricular pacemaker enables optimization of multiple heart parameters to increase cardiac output during and after heart surgery. Adjustments can be made to the atrioventricular heart rate, right-left delay, and site location to readily adapt to patient response. Data are recorded in real time and entered into an algorithm that rapidly configures the optimal settings on a patient-specific basis. With a simple interface, this technology can be easily implemented in the operating room or intensive care unit.
This technology has shown to improve cardiac function in clinical trials in patients following cardiac surgery.
Applications:
- Post-surgical pacemaker for patients with heart failure
- Perioperative pacing during surgery
- Temporary pacemaker
- Research tool in animal models
Advantages:
- Real-time feedback
- Multiparameter adjustments including right-left delay
- Independent monitoring and pacing of heart chambers
- Simplified for use in the operating room and intensive care unit
- Not restricted to patients in heart block
- Objective data recording
Lead Inventor:
Henry M. Spotnitz, M.D.
Patent Information:
Patent Status
Related Publications:
Brusen RM, Hahn R, Cabreriza SE, Cheng B, Wang DY, Truong W, Spotnitz HM. “Wall thickness, pulmonary hypertension, and diastolic filling abnormalities predict response to postoperative biventricular pacing” J Cardiothorac Vasc Anesth. 2015 Oct; 29(5): 1155-1161.
Wang DY, Kelly LA, Richmond ME, Quinn TA, Cheng B, Spotnitz MD, Cabreriza SE, Naka Y, Stewart AS, Smith CR, Spotnitz HM. “Feasibility of temporary biventricular pacing after off-pump coronary artery bypass grafting in patients with reduced left ventricular function” Tex Heart Inst J. 2013; 40(4): 403-409.
Lu JG, Pensiero A, Aponte-Patel L, Velez de Villa B, Rusanov A, Cheng B, Cabreriza SE, Spotnitz HM. “Short-term reduction in intrinsic heart rate during biventricular pacing after cardiac surgery: a substudy of a randomized clinical trial” J Thorac Cardiovasc Surg. 2013 Dec; 146(6): 1494-1500.
Wang A, Cabreriza SE, Havalad V, Aponte-Patel L, Gonzalez G, Velez de Villa B, Cheng B, Spotnitz HM. “Effects of biventricular pacing on left heart twist and strain in a porcine model of right heart failure” J Surg Res. 2013 Dec; 185(2): 645-652.
Spotnitz HM, Cabreriza SE, Wang DY, Quinn TA, Cheng B, Bedrosian LN, Aponte-Patel L, Smith CR. “Primary endpoints of the biventricular pacing after cardiac surgery trial” Ann Thorac Surg. 2013 Sep; 96(3): 808-815.
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