This technology is a computational discovery platform that pinpoints bacterial genes and gene combinations driving colonization of the mammalian gastrointestinal (GI) tract. It enables the design of engineered strains and gene reagents to advance microbiome research and therapeutic development.
The genetic basis of bacterial colonization in the GI tract remains poorly defined, limiting efforts to predictably control colonization efficiency. Without precise tools, researchers cannot easily isolate or modulate the genes responsible for colonization, slowing the translation of microbiome discoveries into targeted interventions and therapies. These tools are essential for translating discoveries into targeted interventions and for developing therapeutic strategies that require precise control of bacterial colonization in the mammalian GI tract.
This method identifies genes and gene combinations that influence bacterial colonization efficiency in the mammalian gastrointestinal (GI) tract. The approach allows for the selection of candidate genetic factors that can be incorporated into plasmid-based reagents or engineered bacterial strains, which can overexpress or carry the identified genes. These tools enable more precise studies and controlled modulation of bacterial colonization dynamics, offering a foundation for future therapeutic applications.
This technology has been validated with a colonizing E. coli strain in the mouse GI tract.
Patent Pending
IR CU24221
Licensing Contact: Joan Martinez