Technologies
This technology is a computational platform to systematically identify bacterial genes and gene combinations driving colonization of the mammalian gastrointestinal (GI) tract.
The genetic basis of bacterial colonization in the GI tract remains poorly defined, limiting efforts to predictably control colonization efficiency. Without precise tools, researchers cannot easily isolate or modulate the genes responsible for colonization, slowing the translation of microbiome discoveries into targeted interventions and therapies. These tools are essential for translating discoveries into targeted interventions and for developing therapeutic strategies across a wide range of species that require precise control of bacterial colonization in the mammalian GI tract.
This technology is a computational platform that identifies genes and gene combinations that influence bacterial colonization efficiency in the mammalian gastrointestinal (GI) tract. This approach allows for the selection of candidate genetic factors that can be incorporated into plasmid-based reagents or engineered bacterial strains, which can overexpress or carry the identified genes. These tools enable more precise studies and controlled modulation of bacterial colonization dynamics, offering a foundation for future therapeutic applications.
This technology has been validated using a colonizing E. coli strain in the mouse GI tract.
Patent Pending(WO/2026/096887)
IR CU24221
Licensing Contact: Joan Martinez