Conditional Ctip-co mouse strain for studying DNA resection
This technology is a mouse strain with a conditional allele of the Ctip gene, resulting in the production of a truncated Ctip protein, that can be used to study DNA and cancer.
Unmet Need: Mouse strain for studying Ctip inactivation
The CtIP protein is involved in DNA end resection and maintenance of genome stability. Better understanding of CtIP could provide information about cancer development and allow for more personalized treatment strategies. However, mice homozygous for a null Ctip allele are nonviable, and there are currently no mouse strains for studying complete Ctip inactivation in mice.
The Technology: Mouse strain with conditional Ctip allele for effective Ctip inactivation
This mouse strain, Ctip-co, has a Ctip allele that codes for an amino-terminally truncated Ctip protein. Cre-mediated recombination of two loxP sites inserted around an exon resulted in deletion of said exon, rendering the allele functionally null. As such, these mice can be used to study full inactivation of the Ctip protein to better understand its role in DNA repair and tumorigenesis.
This technology has already been used to study mammary tumorigenesis and IgH class switch recombination by alternative end-joining.
Applications:
- Model for cancer development
- Drug screening
- Research tool for DNA editing
- Diagnostic tool for personalized cancer diagnosis
Advantages:
- Viable in vivo model of complete Ctip inactivation
- Versatile tool for studying tumor suppression and tumorigenesis
- Can be combined with common mutations in human cancer
Lead Inventor:
Related Publications:
Tech Ventures Reference:
IR CU23028
Licensing Contact: Joan Martinez