This technology is a mouse strain with a conditional allele of the Ctip gene, resulting in the production of a truncated Ctip protein, that can be used to study DNA and cancer.
The CtIP protein is involved in DNA end resection and maintenance of genome stability. Better understanding of CtIP could provide information about cancer development and allow for more personalized treatment strategies. However, mice homozygous for a null Ctip allele are nonviable, and there are currently no mouse strains for studying complete Ctip inactivation in mice.
This mouse strain, Ctip-co, has a Ctip allele that codes for an amino-terminally truncated Ctip protein. Cre-mediated recombination of two loxP sites inserted around an exon resulted in deletion of said exon, rendering the allele functionally null. As such, these mice can be used to study full inactivation of the Ctip protein to better understand its role in DNA repair and tumorigenesis.
This technology has already been used to study mammary tumorigenesis and IgH class switch recombination by alternative end-joining.
IR CU23028
Licensing Contact: Joan Martinez