Conditional knockout mouse model for the Phf6 gene

This technology is a conditional knockout mouse model for the PHD finger protein 6 (Phf6) gene.

Unmet Need: An in vivo model to study the Phf6 gene

Mutations in the Phf6 gene can result in Börjeson-Forssman-Lehmann syndrome, and are associated with T-cell acute lymphoblastic Leukemia, Acute Myeloid Leukemia, and lymphoid neoplasms. Animal models are necessary to better understand the role of Phf6 and develop targeted treatments for these disorders. However, there are currently no animal models to study mutations or knockout of Phf6 in vivo.

The Technology: Conditional knockout mouse model to study the Phf6 gene

This technology is a mouse model that allows for the conditional knockout of the Phf6 gene. It can be used to study Börjeson-Forssman-Lehmann syndrome and screen targeted treatments. It can also be used to understand the role of Phf6 in hematological malignancies and the regulation of blood stem and progenitor cells.

Applications:

• Drug screening
• Research tool for studying the role of PHD finger protein 6 (Phf6)
• Research platform for studying Börjeson-Forssman-Lehmann syndrome

Advantages:

• Replicates human diseases associated with Phf6
• Creates consistent and reproducible genetic knockouts
• Knocks out Phf6 only in specific tissues of interest

Lead Inventor:

Teresa Palomero Vazquez, Ph.D.

Related Publications:

Tech Ventures Reference:

• IR CU22370

• Licensing Contact: Joan Martinez