This technology is a conditional knockout mouse model for the PHD finger protein 6 (Phf6) gene.
Mutations in the Phf6 gene can result in Börjeson-Forssman-Lehmann syndrome, and are associated with T-cell acute lymphoblastic Leukemia, Acute Myeloid Leukemia, and lymphoid neoplasms. Animal models are necessary to better understand the role of Phf6 and develop targeted treatments for these disorders. However, there are currently no animal models to study mutations or knockout of Phf6 in vivo.
This technology is a mouse model that allows for the conditional knockout of the Phf6 gene. It can be used to study Börjeson-Forssman-Lehmann syndrome and screen targeted treatments. It can also be used to understand the role of Phf6 in hematological malignancies and the regulation of blood stem and progenitor cells.
Teresa Palomero Vazquez, Ph.D.
IR CU22370
Licensing Contact: Joan Martinez