This technology is a mouse model harboring a conditional-null allele of the Bard1 gene (Bard1co).
BRCA1-Associated Ring Domain 1 (BARD1) is a tumor suppressor gene that works in conjunction with BRCA1 to repair damaged DNA and preserve genome stability. Mutations in BARD1 are associated with an increased risk for breast and ovarian cancers, however the mechanism and cancer risk are not well understood. Animal models are necessary to better understand the role of BARD1, and develop targeted treatments for these disorders. However, there are currently no animal models to study mutations or knockout of BARD1 in vivo.
This is a mouse model that allows for tissue-specific conditional knockout of the BARD1 gene. Cre-mediated recombination of two loxP sites inserted around an exon results in deletion of said exon, preventing expression of BARD1 protein, and rendering the allele functionally null. As such, his model can be used to investigate the role and mechanism of BARD1 in increasing cancer risk. It can also be used to study the role of BARD1 in relation to BRCA1-related cancers.
IR CU23026
Licensing Contact: Joan Martinez
