Columbia Technology Ventures

Endoscopic imaging device for precise real-time detection of olfactory tissue

This technology is a live imaging device for detecting olfactory epithelial tissue during endoscopic procedures of the head and neck that can be used to accurately identify and avoid damage to the olfactory epithelium in real-time.

Unmet Need: Real-time identification of olfactory tissue during surgery

During sinus, head, and neck surgeries, patients may suffer from surgery-induced injury of the olfactory epithelium (OE), resulting in loss of smell and decreased quality of life. This results from the inability to differentiate the OE from other mucosal layers. Current methods to detect the OE during surgical procedures rely on intravenous delivery of labeling probes, which can be time-consuming during a live endoscopic procedure.

The Technology: Live surgical imaging technique to identify and preserve olfactory tissue

This technology is a spectral imaging system that allows for proper identification of the olfactory epithelium (OE) during endoscopic surgery. Emission spectra of the OE can be used to differentiate it from surrounding tissue. As such, the technology equips existing endoscopic telescopes with the capability of detecting key spectral regions of the OE in real-time. The spectral mapping can be superimposed onto live feeds from the endoscope, allowing clinicians to identify and avoid damage to the OE during live surgical procedures.

Applications:

  • Live detection of olfactory epithelium for prevention of tissue damage during surgery
  • Clinical tool for detection and spectral mapping of tissue during endoscopic procedures
  • Diagnostic assays for asomnia and other olfactory epithelium-related illness
  • Diagnostic tool for olfactory epithelium biopsies
  • Research tool to improve detection techniques for other tissue types in the body
  • Research tool to develop quick, non-invasive biopsy and detection of tissues

Advantages:

  • Precisely identifies and differentiates olfactory epithelium tissue
  • Enables real-time tissue identification and surgical adjustment
  • Avoids tissue damage during surgery
  • Compatible with existing endoscope technology
  • Does not require IV administration of labeling probes
  • No patient risk or change in surgical procedures
  • Rapid, real-time imaging

Lead Inventor:

James Schuck, Ph.D.

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