This technology is an advanced complementary metal-oxide semiconductor (CMOS) amplifier nanopore sensor, enhancing the measurement of transient ionic currents, applicable in drug screening and disease diagnostics.
The traditional methods for ion channel kinetics analysis involve intact-cell patch-clamp or model lipid bilayer techniques. These existing methods, limited by lower resolution and slower throughput, present challenges that include low bandwidth and high electrical noise, restricting the detailed and efficient study of ion channels, which is critical for drug discovery and diagnostics.
The technology is built on a complementary metal-oxide semiconductor (CMOS) amplifier integrated with nanopores, offering multichannel parallel sensing of single molecules, and enhanced signal-to-noise ratio and bandwidth. Its design, with lower parasitic capacitance, allows for the detection of transient signals as brief as 1 μs, and is robust and adaptable to various biochemical interactions, such as lipid bilayers or intact cells.
Patent Issued (US10,627,364)
IR CU12278, M11-069
Licensing Contact: Greg Maskel