Profuse bleeding, known as hemorrhage, is a significant mortality factor in battlefield and civilian trauma environments. Normally, our bodies resolve hemorrhages through a physiological processes involving platelet activation and the coagulation cascade, but in traumatic cases, surgical repair is often necessary. Commercially available hemostatic dressings, such as dressing or bandage can help stabilize a traumatic hemorrhage before surgery can occur. This technology describes a combination of hemostatic potentiators on a dressing or bandage to improve hemostatic control of a traumatic hemorrhage. The added hemostatic factors promote platelet aggregation and activation of the coagulation cascade. Thus, the enhanced hemostatic dressing may be applied in traumatic situations where it is necessary to staunch excessive bleeding.
Current commercially available hemostatic dressings typically contain at most only one or two factors that can potentiate the coagulation cascade. This technology describes a combination of multiple factors with known mechanisms of action to help control blood loss. The ingredients enable platelet aggregation, coagulation activation and increased absorptive capacity, resulting in a stable hemostatic plug. In addition, the formula is inexpensive and the dressing is pliable and stable for over two weeks.
The increased efficacy of the technology at controlling hemorrhage was demonstrated using vascular injury tests on animals.
Matthew Bacchetta, MD, MBA, MA.
Patent Pending (WO/2013/056116)
Tech Ventures Reference: IR 2424 and IR 2950