This technology improves experimental and post-processing procedures for in vivo proton magnetic resonance spectroscopy.
In vivo proton magnetic resonance spectroscopy (1H MRS) is a powerful technique that identifies the concentration, distribution, and function of metabolites in patients. However, the high water content in biological samples typically requires a method to suppress water signals. Current 1H MRS methods suppress water signals in processes that require extensive scan times, can potentially damage biological samples, and result in spectra with low spatial resolution. As such, there is a need for experimental methods and post processing procedures for in vivo 1H MRS without suppressing water signals.
This technology is a method for performing 1H MRS without water suppression that employs three gradients for localization, spatial encoding, and reduction of unwanted signals. Rather than suppressing the water signal, this technology uses water as a reference to produce highly accurate quantitative mapping of metabolites. The experimental modifications only add a few seconds to the scan time and can be easily incorporated into existing 1H MRS imaging sequences for robust metabolite detection. As a result, this technology will interface with existing 1H MRS equipment and methods to improve the quality of metabolite detection in both research and clinical settings.
IR CU18050
Licensing Contact: Ron Katz