Modified exosomes for enhanced cargo delivery

This technology is an exosome-based delivery system loaded with bioenergetic substances to increase the cellular uptake of cargo biomolecules.

Unmet Need: Increased endocytosis of therapeutic-containing exosomes

Extracellular vesicles, such as exosomes, have become a promising therapeutic delivery system due to their versatility and biocompatibility. However, the use of exosomes for targeted delivery is currently limited by the rate of cellular uptake of these particles and their cargo. Given the active manner of exosome endocytosis, exosome uptake is an energy intensive process for the cell.

The Technology: ATP-loaded exosome system for improved drug delivery

This technology is a method to enhance the cellular uptake of extracellular vesicles and exosomes by loading them with ATP and/or other energy-carrying molecules. Exosomes loaded with ATP are shown to have enhanced uptake by cells compared to unloaded exosomes. This system can also be used to load exosomes with other forms of biochemical energy, such as NADH or FADH₂, to improve cellular uptake.

This technology has been validated in vitro with human epithelial cells.

Applications:

• Therapeutic delivery
• Tissue-targeted gene editing
• Vaccine production

Advantages:

• Enhanced cellular uptake
• Can be loaded with a variety of bioenergetic molecules
• Can be modified to target particular tissue types
• Low immunogenicity
• Biocompatibility

Lead Inventor:

Akiva Mintz, MD, PhD

Patent Information:

Patent Pending(WO/2022/170176)

Related Publications:

Tech Ventures Reference:

• IR CU2006, CU21165, CU23353

• Licensing Contact: Joan Martinez