Monoclonal Antibody Enhancing T Cell Reactivity in AIDS Treatments

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Unmet Need: Method for modulating immune response with ligands for natural killer T cells.
A great diversity of lipids and glycolipids have been shown to bind to the various isoforms of CD1 and activate natural killer T cells.
This technology describes a series of novel compounds that have been identified to act as ligands for natural killer T cells and modulate the immune response of these cells.
This technology is a tri-specific antibody targeting multiple epitopes of the human immunodeficiency virus (HIV) for immunotherapy against HIV infection and prevention of viral transmission.
Unmet Need: Multiple epitope specific antibody for treatment of HIV.
Alternatives in development include antibody therapy applied biannually, including monoclonal and bispecific antibodies which may also decrease the reservoir of infected T cells.
Drug screening for AIDS and cancer therapeutics.
The Technology: Easy-to-handle CD4+ human cancer cell line for AIDS research.
More studies are needed to dissect the mechanisms by which CD4 antigen contributes to AIDS virus infection.
    • Tags
      • 20
        T cell
      • 14
        Immunotherapy
      • 13
        Neoplasm
      • 11
        Cytotoxic T cell
      • 11
        Antigen
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    • Categories
      • 24
        Biology
      • 23
        Biological systems
      • 23
        Organ systems
      • 22
        Immune system
      • 23
        Branches of biology
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    • Inventors
      • 4
        David Da-i Ho M.D.
      • 4
        Hong Jiang
      • 4
        Leonard Chess MD
      • 3
        John Loike
      • 3
        Raphael Clynes MD, PhD
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    • Manager
      • 8
        Sara Gusik
      • 6
        Jerry Kokoshka
      • 5
        Kristin Neuman
      • 4
        Joan Martinez
      • 1
        Cynthia Lang
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    • Departments
      • 15
        Medicine
      • 4
        Biochemistry & Molecular Biophysics
      • 3
        Physicians & Surgeons
      • 3
        Physiology
      • 3
        Physiology and Cellular Biophysics
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    • Divisions
      • 23
        Columbia University Medical Center (CUMC)
      • 2
        College of Physicians and Surgeons (CUMC)
      • 1
        Hematology
      • 1
        School of Medicine
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    • Reference Number
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    • Release Date
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