Monoclonal Antibody Enhancing T Cell Reactivity in AIDS Treatments
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Unmet Need: Method for modulating immune response with ligands for natural killer T cells. A great diversity of lipids and glycolipids have been shown to bind to the various isoforms of CD1 and activate natural killer T cells. This technology describes a series of novel compounds that have been identified to act as ligands for natural killer T cells and modulate the immune response of these cells.
This technology is a tri-specific antibody targeting multiple epitopes of the human immunodeficiency virus (HIV) for immunotherapy against HIV infection and prevention of viral transmission. Unmet Need: Multiple epitope specific antibody for treatment of HIV. Alternatives in development include antibody therapy applied biannually, including monoclonal and bispecific antibodies which may also decrease the reservoir of infected T cells.
Drug screening for AIDS and cancer therapeutics. The Technology: Easy-to-handle CD4+ human cancer cell line for AIDS research. More studies are needed to dissect the mechanisms by which CD4 antigen contributes to AIDS virus infection.
- 20T cell
- 14Immunotherapy
- 13Neoplasm
- 11Cytotoxic T cell
- 11Antigen
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- 24Biology
- 23Biological systems
- 23Organ systems
- 22Immune system
- 23Branches of biology
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- 4David Da-i Ho M.D.
- 4Hong Jiang
- 4Leonard Chess MD
- 3John Loike
- 3Raphael Clynes MD, PhD
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- 8Sara Gusik
- 6Jerry Kokoshka
- 5Kristin Neuman
- 4Joan Martinez
- 1Cynthia Lang
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- 15Medicine
- 4Biochemistry & Molecular Biophysics
- 3Physicians & Surgeons
- 3Physiology
- 3Physiology and Cellular Biophysics
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- 23Columbia University Medical Center (CUMC)
- 2College of Physicians and Surgeons (CUMC)
- 1Hematology
- 1School of Medicine
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