This technology is a mouse model enabling Cre-inducible expression of peroxisome proliferator-activated receptor gamma (PPARG) in specific tissues.
PPARG is a nuclear receptor protein associated with various disease states such as diabetes, cancers, and neurodegenerative disorders. Currently available mouse models for the control of PPARG expression involve genetic knockouts or time-inducible control of PPARG expression in its native tissue types, but to date no model exists that enables PPARG expression in non-native tissues. There is a need for a mouse line that allows researchers to study the effects of aberrant PPARG expression in tissue types where PPARG may not be normally expressed, in order to elucidate its widespread role in diverse disease states.
This technology describes a transgenic mouse model that enables Cre-inducible expression of PPARG. Importantly, it will allow tissue-specific expression of PPARG in any desired tissue type, including non-native tissues. The mouse line can be crossed with virtually any Cre driver mouse line and allows for simultaneous expression of PPARG and a reporter, enabling visualization of PPARG expression using fluorescence microscopy methods. This technology will therefore help advance research in various disease states where PPARG expression is dysregulated.
IR CU20098
Licensing Contact: Joan Martinez