This technology is an electrospun scaffold coated with immunomodulatory liposome-based nanoparticles for enhanced wound healing.
Scaffolds are widely used in clinical procedures for wound healing, providing structural stability and a suitable mechanical environment for tissue regeneration. However, these scaffolds are currently limited in their ability to deliver drugs and biological signals to more actively promote tissue regeneration. On the other hand, nanoparticles and liposomes have been extensively employed for drug delivery and biological signaling, particularly in immune engineering, but face challenges related to biodistribution and retention within target areas.
This technology describes electrospun scaffolds functionalized with immunomodulatory liposome-based nanoparticles to introduce potent anti-inflammatory cues and increase wound healing. This technology provides both pro-survival mechanical and electrical cues from the scaffold and biomolecular and biochemical cues from the nanoparticles. A diversity of nanoparticles can be integrated into the scaffold, providing a modular method of introducing a variety of cellular signaling cues. This technology has the potential to enhance functional wound healing by more effectively engaging immune cells involved in tissue regeneration.
Treena Arinzeh, Ph.D.
Santiago Correa, Ph.D.
Patent Pending
IR CU24234
Licensing Contact: Dovina Qu
