Novel diagnostic and treatment method for Alzheimer's disease
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“Increased localization of APP‐C99 in mitochondria‐associated ER membranes causes mitochondrial dysfunction in Alzheimer disease” EMBO J. Schon, Ph.D.
Patent Information:
Patent Pending (US20220395486). This technology reduces a patient’s level of endoplasmic reticulum-mitochondrial-associated membrane (ER-MAM) localized APP-C99 in cells using a variety of different pharmacological approaches, including but not limited to γ-secretase activators.
Therapeutic for other neurodegenerative disorders, including Welander distal myopathy (WDM), a rare autosomal dominant disorder caused by a missense mutation in the human TIA1 gene. Small molecules penetrate the CNS and pass through cell membranes (unlike main competitors, which are antibody-based). Most current anti-tau therapies in development are immunotherapies, which have thus far been ineffective, in large part because of poor antibody penetration into the CNS and poor membrane permeability.
Miranda AM, Ashok A, Chan RB, Zhou B, Xu Y, McIntire LB, Area-Gomez E, Di Paolo G, Duff KE, Oliveira TG, Nuriel T.
- 16Neurodegeneration
- 9High-throughput screening
- 8Amyloid beta
- 7Dementia
- 7Neuron
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- 24Biology
- 22Branches of biology
- 16Neuroscience
- 13Medicine
- 12Biotechnology
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- 3Caghan Kizil
- 3Donald William Landry MD, Ph.D.
- 3Laura Beth Johnson McIntire
- 3Shi-xian Deng
- 3Tae-Wan Kim Ph.D.
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- 8Jerry Kokoshka
- 7Kristin Neuman
- 6Sara Gusik
- 2Joan Martinez
- 1Dovina Qu
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- 8Neurology
- 8Pathology
- 3Medicine
- 2Neuroscience
- 2Physiology and Cellular Biophysics
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- 21Columbia University Medical Center (CUMC)
- 3College of Physicians and Surgeons (CUMC
- 1Center for Cancer Cell Reprogramming
- 1Center for Infectious Diseases
- 1College of Physicians and Surgeons (CUMC)
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