Columbia Technology Ventures

Optically-powered micron-scale chip for electrophysiological measurements and intracellular probes

This technology is an optically-powered complementary metal-oxide-semiconductor (CMOS) chip designed for minimally-invasive electrophysiological measurements and intracellular monitoring of biological systems.

Unmet Need: Biocompatible, minimally-invasive electronic probes

Implantable and injectable integrated circuits (IC’s) provide great promise for opening up functionalities in life science research and future device applications. However, implementing a fully implantable system is difficult due to issues with device size, power delivery, and communication. Ideally, devices are less than ten microns in each dimension, allowing the ICs to be injectable and potentially diffusible through tissue. Furthermore, while wireless power delivery methods using radio-frequency and ultrasound exist, they are constrained by the device’s size and required proximity to external transducers, making such technology difficult to implement at the micron scale.

The Technology: Optically-powered, implantable integrated circuit for minimally-invasive biological probes

This technology is an injectable IC chip that can be powered wirelessly by visible light and is less than ten microns in each dimension. The small size of the chip is accomplished through chip-thinning techniques. Integrated photovoltaic cells allow incident light on the chip to be converted into usable electrical power. Additionally, quantum dot capacitors can be used to perform optical data transfer via fluorescence modulation, thereby yielding optical signals which can be captured by a variety of imaging tools such as cameras on fluorescent microscopes. As such, the size and wireless power harvesting capabilities of this technology allow for IC chips to be injected directly into tissue and potentiate a class of fully-injectable electronic devices.

Applications:

  • Minimally-invasive biological probes
  • Non-destructive sensing and imaging of a cell and/or tissue sample
  • Low-power energy harvesting for microelectronics
  • Optical data communication between microelectronic nodes on CMOS
  • Potential use for solar/light powered applications with low voltage requirements

Advantages:

  • Minimally-invasive technology enabled by micron-scale dimensions
  • Powered by incident light
  • Enables precise electrophysiological measurements that are impossible with surgically injectable probes

Lead Inventor:

Kenneth Shepard, Ph.D.

Patent Information:

Patent Status

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